ENSMUSG00000075316


Mus musculus

Features
Gene ID: ENSMUSG00000075316
  
Biological name :Scn9a
  
Synonyms : Q62205 / Scn9a / Sodium channel protein type 9 subunit alpha
  
Possible biological names infered from orthology : Q15858 / sodium voltage-gated channel alpha subunit 9
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 66480080
Gene end: 66634962
  
Corresponding Affymetrix probe sets: 10472372 (MoGene1.0st)   10472374 (MoGene1.0st)   10483324 (MoGene1.0st)   10483326 (MoGene1.0st)   1421660_at (Mouse Genome 430 2.0 Array)   1442333_a_at (Mouse Genome 430 2.0 Array)   1442809_at (Mouse Genome 430 2.0 Array)   1442810_x_at (Mouse Genome 430 2.0 Array)   1457819_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126528
Ensembl peptide - ENSMUSP00000131711
Ensembl peptide - ENSMUSP00000097641
Ensembl peptide - ENSMUSP00000097642
Ensembl peptide - ENSMUSP00000107973
NCBI entrez gene - 20274     See in Manteia.
MGI - MGI:107636
RefSeq - XM_006499033
RefSeq - XM_006499036
RefSeq - XM_006499035
RefSeq - NM_001290674
RefSeq - NM_001290675
RefSeq Peptide - NP_001277603
RefSeq Peptide - NP_001277604
swissprot - Q62205
swissprot - E9PW82
swissprot - B1AYL0
swissprot - F8VPQ7
Ensembl - ENSMUSG00000075316
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn1aENSDARG00000086819Danio rerio
 scn1labENSDARG00000062744Danio rerio
 SCN9AENSGALG00000027793Gallus gallus
 SCN9AENSG00000169432Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scn2a / sodium channel, voltage-gated, type II, alpha / Q99250* / sodium voltage-gated channel alpha subunit 2*ENSMUSG0000007531879
Scn1a / A2APX8 / Sodium channel protein type 1 subunit alpha / P35498* / sodium voltage-gated channel alpha subunit 1*ENSMUSG0000006432977
Scn3a / sodium channel, voltage-gated, type III, alpha / Q9NY46* / sodium voltage-gated channel alpha subunit 3*ENSMUSG0000005718275
Scn8a / sodium channel, voltage-gated, type VIII, alpha / Q9UQD0* / sodium voltage-gated channel alpha subunit 8*ENSMUSG0000002303370
Scn5a / Q9JJV9 / Sodium channel protein type 5 subunit alpha / Q14524* / sodium voltage-gated channel alpha subunit 5*ENSMUSG0000003251163
Scn4a / sodium channel, voltage-gated, type IV, alpha / P35499* / sodium voltage-gated channel alpha subunit 4*ENSMUSG0000000102763
Q6QIY3 / Scn10a / sodium channel, voltage-gated, type X, alpha / Q9Y5Y9* / sodium voltage-gated channel alpha subunit 10*ENSMUSG0000003453355
Q9R053 / Scn11a / Sodium channel protein type 11 subunit alpha / Q9UI33* / sodium voltage-gated channel alpha subunit 11*ENSMUSG0000003411546
Scn7a / sodium voltage-gated channel alpha subunit 7 / Q01118*ENSMUSG0000003481045
Cacna1h / voltage-dependent T-type calcium channel subunit alpha-1H isoform 2 / O95180* / calcium voltage-gated channel subunit alpha1 H*ENSMUSG0000002411226
Cacna1i / calcium channel, voltage-dependent, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I*ENSMUSG0000002241624
Cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSMUSG0000002086624


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR024583  Voltage-gated Na+ ion channel, cytoplasmic domain
 IPR028803  Voltage gated sodium channel, alpha-9 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009636 response to toxic substance IDA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0019228 neuronal action potential IBA
 biological_processGO:0019233 sensory perception of pain ISS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport ISS
 biological_processGO:0048266 behavioral response to pain IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031402 sodium ion binding IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000516 abnormal urinary system morphology "structural or developmental anomaly of any of the organs involved in the production or excretion of urine " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: B6.129P2-Scn9atm1Dgen/J

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: B6.129P2-Scn9atm1Dgen/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: B6.129P2-Scn9atm1Dgen/J

 MP:0001499 kindling "long-lasting epileptogenic changes induced by daily sub threshold electrical brain stimulation, induced model for epilepsy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45446]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001650 electrically induced seizures "high or low frequency electrical stimulation applied to induce seizure activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Droshatm3Vlcg/Droshatm3Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002193 minimal clonic seizures "seizures involving rhythmic face and forelimb clonus including arm movement, and it may include rearing and falling and ventral flexion of the neck; a seizure is scored as minimal when it satisfies the minimal criteria up to or including ventral flexion, but does not include maximal tonic hindlimb extension" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, wf:Wayne Frankel , TJL staff]
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Allelic Composition: Ahi1tm1Jgg/Ahi1tm1Jgg,Tg(TCF/Lef1-lacZ)34Efu/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0003635 abnormal synaptic transmission "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0004512 anosmia "loss of the sense of smell" [mberry:Melissa Berry_Genetic Resources Curator]
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Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: either: (involves: 129P2/OlaHsd * BALB/c * C57BL/6) or (involves: 129P2/OlaHsd * C57BL/6 * CD-1)

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Terttm1Yjc/Terttm1Yjc
Genetic Background: involves: C57BL/6 * SPRET/Ei

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: B6.129P2-Scn9atm1Dgen/J

Allelic Composition: Scn9atm1Dgen/Scn9atm1Dgen
Genetic Background: C.129P2(B6)-Scn9atm1Dgen

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Selptm1Bay/Selptm1Bay
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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