ENSDARG00000062744


Danio rerio

Features
Gene ID: ENSDARG00000062744
  
Biological name :scn1lab
  
Synonyms : scn1lab / sodium channel, voltage-gated, type I like, alpha b
  
Possible biological names infered from orthology : A2APX8 / P35498 / Q01118 / Q15858 / Q62205 / Q99250 / Q9NY46 / SCN1A / SCN2A / SCN3A / SCN7A / SCN9A / Sodium channel protein type 1 subunit alpha / Sodium channel protein type 9 subunit alpha / sodium channel, voltage-gated, type II, alpha / sodium channel, voltage-gated, type III, alpha / sodium voltage-gated channel alpha subunit 1 / sodium voltage-gated channel alpha subunit 2 / sodium voltage-gated channel alpha subunit 3 / sodium voltage-gated channel alpha subunit 7 / sodium voltage-gated channel alpha subunit 9
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 10248332
Gene end: 10320676
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000125843
Ensembl peptide - ENSDARP00000085427
NCBI entrez gene - 559447     See in Manteia.
RefSeq - XM_005165770
RefSeq - XM_021476884
RefSeq - XM_009302186
RefSeq - NM_001044895
RefSeq Peptide - NP_001038360
swissprot - F1QXF5
ZFIN ID - ZDB-GENE-060906-1
Ensembl - ENSDARG00000062744
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCN1AENSGALG00000010943Gallus gallus
 SCN2AENSGALG00000011009Gallus gallus
 SCN3AENSGALG00000011040Gallus gallus
 SCN9AENSGALG00000027793Gallus gallus
 SCN1AENSG00000144285Homo sapiens
 SCN2AENSG00000136531Homo sapiens
 SCN3AENSG00000153253Homo sapiens
 SCN7AENSG00000136546Homo sapiens
 SCN9AENSG00000169432Homo sapiens
 Scn1aENSMUSG00000064329Mus musculus
 Scn2aENSMUSG00000075318Mus musculus
 Scn3aENSMUSG00000057182Mus musculus
 Scn7aENSMUSG00000034810Mus musculus
 Scn9aENSMUSG00000075316Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
scn8ab / sodium channel, voltage gated, type VIII, alpha subunit b / SCN8A* / Q9UQD0* / sodium voltage-gated channel alpha subunit 8* / sodium channel, voltage-gated, type VIII, alpha*ENSDARG0000001803273
scn8aa / sodium channel, voltage gated, type VIII, alpha subunit a / SCN8A* / Q9UQD0* / sodium voltage-gated channel alpha subunit 8* / sodium channel, voltage-gated, type VIII, alpha*ENSDARG0000000577572
scn1a / sodium channel, voltage-gated, type I, alpha / SCN9A* / SCN3A* / SCN2A* / SCN7A* / A2APX8* / P35498* / Q01118* / Q15858* / Q62205* / Q99250* / Q9NY46* / sodium voltage-gated channel...ENSDARG0000008681968
scn12ab / sodium channel, voltage gated, type XII, alpha b / SCN5A* / Q9R053* / Q9UI33* / Q9Y5Y9* / SCN10A* / SCN11A* / Q14524* / Q6QIY3* / Q9JJV9* / Sodium channel protein type 5 subunit a...ENSDARG0000010231265
scn12aa / sodium channel, voltage gated, type XII, alpha a / SCN5A* / Q9R053* / Q9UI33* / Q9Y5Y9* / SCN10A* / SCN11A* / Q14524* / Q6QIY3* / Q9JJV9* / Sodium channel protein type 5 subunit a...ENSDARG0000009072464
scn4aa / sodium channel, voltage-gated, type IV, alpha, a / SCN4A* / P35499* / sodium voltage-gated channel alpha subunit 4* / sodium channel, voltage-gated, type IV, alpha*ENSDARG0000009873859
scn4ab / sodium channel, voltage-gated, type IV, alpha, b / SCN4A* / P35499* / sodium voltage-gated channel alpha subunit 4* / sodium channel, voltage-gated, type IV, alpha*ENSDARG0000003458858
cacna1ha / calcium channel, voltage-dependent, T type, alpha 1H subunit a / O95180* / CACNA1H* / calcium voltage-gated channel subunit alpha1 H* / voltage-dependent T-type calcium channel s...ENSDARG0000006049624
cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSDARG0000008991323
cacna1i / calcium channel, voltage-dependent, T type, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I* / calcium channel, voltage-dependent, alpha 1I subunit*ENSDARG0000007052222
cacna1hb / calcium channel, voltage-dependent, T type, alpha 1H subunit b / O95180* / CACNA1H* / calcium voltage-gated channel subunit alpha1 H* / voltage-dependent T-type calcium channel s...ENSDARG0000009970818
si:ch73-379f7.5 / CACNA1I (1 of many) / Q9P0X4* / CACNA1I* / calcium voltage-gated channel subunit alpha1 I* / calcium channel, voltage-dependent, alpha 1I subunit*ENSDARG0000009630710
LO017974.1 / Q9P0X4* / CACNA1I* / calcium voltage-gated channel subunit alpha1 I*ENSDARG000001157415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR024583  Voltage-gated Na+ ion channel, cytoplasmic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002082 regulation of oxidative phosphorylation IMP
 biological_processGO:0006110 regulation of glycolytic process IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0019228 neuronal action potential IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0036269 swimming behavior IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 biological_processGO:0099536 synaptic signaling IMP
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IBA
 molecular_functionGO:0005272 sodium channel activity IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain functionality , abnormal
brain synaptic signaling ictal , ameliorated
brain synaptic signaling ictal , abnormal
Show

 ZFA:0000037 anatomical structure anatomical structure amount , ameliorated
anatomical structure decreased amount , abnormal
anatomical structure increased amount , abnormal
Show

 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
swim bladder absent , abnormal
Show

 ZFA:0000107 eye eye movement quality , abnormal
Show

 ZFA:0000109 forebrain forebrain neuronal action potential process quality , abnormal
forebrain neuronal action potential process quality , ameliorated
Show

 ZFA:0001094 whole organism whole organism increased behavioural activity , abnormal
whole organism increased pigmentation , abnormal
whole organism anatomical axis curved , abnormal
whole organism low brightness , abnormal
whole organism dead , abnormal
Show

 ZFA:0001115 trunk trunk curved , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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