ENSG00000136546


Homo sapiens

Features
Gene ID: ENSG00000136546
  
Biological name :SCN7A
  
Synonyms : Q01118 / SCN7A / sodium voltage-gated channel alpha subunit 7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q24.3
Gene start: 166403573
Gene end: 166494326
  
Corresponding Affymetrix probe sets: 207864_at (Human Genome U133 Plus 2.0 Array)   228504_at (Human Genome U133 Plus 2.0 Array)   239984_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000413699
Ensembl peptide - ENSP00000478562
Ensembl peptide - ENSP00000496114
Ensembl peptide - ENSP00000481734
Ensembl peptide - ENSP00000386796
Ensembl peptide - ENSP00000396600
Ensembl peptide - ENSP00000403846
NCBI entrez gene - 6332     See in Manteia.
OMIM - 182392
RefSeq - XM_017004667
RefSeq - XM_006712682
RefSeq - XM_011511615
RefSeq - XM_006712681
RefSeq - XM_006712680
RefSeq - NM_002976
RefSeq Peptide - NP_002967
swissprot - Q01118
swissprot - C9JII9
swissprot - F8WD82
swissprot - C9JW43
Ensembl - ENSG00000136546
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn1aENSDARG00000086819Danio rerio
 scn1labENSDARG00000062744Danio rerio
 SCN9AENSGALG00000027793Gallus gallus
 Scn7aENSMUSG00000034810Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SCN9A / Q15858 / sodium voltage-gated channel alpha subunit 9ENSG0000016943256
SCN2A / Q99250 / sodium voltage-gated channel alpha subunit 2ENSG0000013653154
SCN1A / P35498 / sodium voltage-gated channel alpha subunit 1ENSG0000014428553
SCN3A / Q9NY46 / sodium voltage-gated channel alpha subunit 3ENSG0000015325353
SCN8A / Q9UQD0 / sodium voltage-gated channel alpha subunit 8ENSG0000019687651
SCN4A / P35499 / sodium voltage-gated channel alpha subunit 4ENSG0000000731450
SCN5A / Q14524 / sodium voltage-gated channel alpha subunit 5ENSG0000018387348
Q9Y5Y9 / SCN10A / sodium voltage-gated channel alpha subunit 10ENSG0000018531345
Q9UI33 / SCN11A / sodium voltage-gated channel alpha subunit 11ENSG0000016835640
O95180 / CACNA1H / calcium voltage-gated channel subunit alpha1 HENSG0000019655723
Q9P0X4 / CACNA1I / calcium voltage-gated channel subunit alpha1 IENSG0000010034622
O43497 / CACNA1G / calcium voltage-gated channel subunit alpha1 GENSG0000000628322


Protein motifs (from Interpro)
Interpro ID Name
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR028812  Voltage gated sodium channel, alpha-7 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport TAS
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0019228 neuronal action potential IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055078 sodium ion homeostasis IDA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0097386 glial cell projection IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity TAS
 molecular_functionGO:0005272 sodium channel activity IEA


Pathways (from Reactome)
Pathway description
Interaction between L1 and Ankyrins
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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