ENSDARG00000086819


Danio rerio

Features
Gene ID: ENSDARG00000086819
  
Biological name :scn1a
  
Synonyms : scn1a / sodium channel, voltage-gated, type I, alpha
  
Possible biological names infered from orthology : A2APX8 / P35498 / Q01118 / Q15858 / Q62205 / Q99250 / Q9NY46 / SCN2A / SCN3A / SCN7A / SCN9A / Sodium channel protein type 1 subunit alpha / Sodium channel protein type 9 subunit alpha / sodium channel, voltage-gated, type II, alpha / sodium channel, voltage-gated, type III, alpha / sodium voltage-gated channel alpha subunit 1 / sodium voltage-gated channel alpha subunit 2 / sodium voltage-gated channel alpha subunit 3 / sodium voltage-gated channel alpha subunit 7 / sodium voltage-gated channel alpha subunit 9
  
Species: Danio rerio
  
Chr. number: 9
Strand: -1
Band:
Gene start: 49906037
Gene end: 50001606
  
Corresponding Affymetrix probe sets: Dr.21060.1.S1_at (Zebrafish Array)   NM_200132_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000105554
Ensembl peptide - ENSDARP00000138437
Ensembl peptide - ENSDARP00000137025
Ensembl peptide - ENSDARP00000135245
Ensembl peptide - ENSDARP00000133081
NCBI entrez gene - 393101     See in Manteia.
RefSeq - NM_200132
RefSeq - XM_017357661
RefSeq Peptide - NP_956426
swissprot - A0A0R4IHZ1
swissprot - A0A0R4I9M7
swissprot - E7FFV4
swissprot - A0A0R4IUM7
swissprot - A0A0R4IQT2
ZFIN ID - ZDB-GENE-040426-751
Ensembl - ENSDARG00000086819
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCN1AENSGALG00000010943Gallus gallus
 SCN2AENSGALG00000011009Gallus gallus
 SCN3AENSGALG00000011040Gallus gallus
 SCN9AENSGALG00000027793Gallus gallus
 SCN1AENSG00000144285Homo sapiens
 SCN2AENSG00000136531Homo sapiens
 SCN3AENSG00000153253Homo sapiens
 SCN7AENSG00000136546Homo sapiens
 SCN9AENSG00000169432Homo sapiens
 Scn1aENSMUSG00000064329Mus musculus
 Scn2aENSMUSG00000075318Mus musculus
 Scn3aENSMUSG00000057182Mus musculus
 Scn7aENSMUSG00000034810Mus musculus
 Scn9aENSMUSG00000075316Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
scn1lab / sodium channel, voltage-gated, type I like, alpha b / SCN1A* / SCN9A* / SCN7A* / SCN2A* / SCN3A* / A2APX8* / P35498* / Q01118* / Q15858* / Q62205* / Q99250* / Q9NY46* / sodium vol...ENSDARG0000006274470
scn8aa / sodium channel, voltage gated, type VIII, alpha subunit a / SCN8A* / Q9UQD0* / sodium voltage-gated channel alpha subunit 8* / sodium channel, voltage-gated, type VIII, alpha*ENSDARG0000000577564
scn8ab / sodium channel, voltage gated, type VIII, alpha subunit b / SCN8A* / Q9UQD0* / sodium voltage-gated channel alpha subunit 8* / sodium channel, voltage-gated, type VIII, alpha*ENSDARG0000001803264
scn12ab / sodium channel, voltage gated, type XII, alpha b / SCN5A* / Q9R053* / Q9UI33* / Q9Y5Y9* / SCN10A* / SCN11A* / Q14524* / Q6QIY3* / Q9JJV9* / Sodium channel protein type 5 subunit a...ENSDARG0000010231261
scn12aa / sodium channel, voltage gated, type XII, alpha a / SCN5A* / Q9R053* / Q9UI33* / Q9Y5Y9* / SCN10A* / SCN11A* / Q14524* / Q6QIY3* / Q9JJV9* / Sodium channel protein type 5 subunit a...ENSDARG0000009072460
scn4aa / sodium channel, voltage-gated, type IV, alpha, a / SCN4A* / P35499* / sodium voltage-gated channel alpha subunit 4* / sodium channel, voltage-gated, type IV, alpha*ENSDARG0000009873856
scn4ab / sodium channel, voltage-gated, type IV, alpha, b / SCN4A* / P35499* / sodium voltage-gated channel alpha subunit 4* / sodium channel, voltage-gated, type IV, alpha*ENSDARG0000003458855
cacna1ha / calcium channel, voltage-dependent, T type, alpha 1H subunit a / O95180* / CACNA1H* / calcium voltage-gated channel subunit alpha1 H* / voltage-dependent T-type calcium channel s...ENSDARG0000006049623
cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSDARG0000008991321
cacna1i / calcium channel, voltage-dependent, T type, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I* / calcium channel, voltage-dependent, alpha 1I subunit*ENSDARG0000007052221
cacna1hb / calcium channel, voltage-dependent, T type, alpha 1H subunit b / O95180* / CACNA1H* / calcium voltage-gated channel subunit alpha1 H* / voltage-dependent T-type calcium channel s...ENSDARG0000009970818
si:ch73-379f7.5 / CACNA1I (1 of many) / Q9P0X4* / CACNA1I* / calcium voltage-gated channel subunit alpha1 I* / calcium channel, voltage-dependent, alpha 1I subunit*ENSDARG0000009630710
LO017974.1 / Q9P0X4* / CACNA1I* / calcium voltage-gated channel subunit alpha1 I*ENSDARG000001157414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR024583  Voltage-gated Na+ ion channel, cytoplasmic domain
 IPR031649  Voltage-dependent L-type calcium channel, IQ-associated domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0001518 voltage-gated sodium channel complex IC
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IMP
 molecular_functionGO:0005272 sodium channel activity IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain transmission of nerve impulse process quality , abnormal
brain transmission of nerve impulse process quality , ameliorated
Show

 ZFA:0000109 forebrain forebrain transmission of nerve impulse process quality , abnormal
forebrain transmission of nerve impulse process quality , ameliorated
Show

 ZFA:0009120 mechanoreceptor cell mechanoreceptor cell voltage-gated sodium channel complex decreased functionality , abnormal
Show

 ZFA:0009150 Rohon-Beard neuron Rohon-Beard neuron membrane potential , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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