ENSMUSG00000057182


Mus musculus

Features
Gene ID: ENSMUSG00000057182
  
Biological name :Scn3a
  
Synonyms : Scn3a / sodium channel, voltage-gated, type III, alpha
  
Possible biological names infered from orthology : Q9NY46 / sodium voltage-gated channel alpha subunit 3
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: C1.3
Gene start: 65457118
Gene end: 65567627
  
Corresponding Affymetrix probe sets: 10472374 (MoGene1.0st)   10483215 (MoGene1.0st)   10483228 (MoGene1.0st)   1421705_at (Mouse Genome 430 2.0 Array)   1439204_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065023
Ensembl peptide - ENSMUSP00000097647
Ensembl peptide - ENSMUSP00000115321
NCBI entrez gene - 20269     See in Manteia.
MGI - MGI:98249
RefSeq - XM_017316723
RefSeq - NM_018732
RefSeq - XM_011239390
RefSeq - XM_011239391
RefSeq - XM_011239392
RefSeq - XM_011239393
RefSeq - XM_011239394
RefSeq - XM_017316721
RefSeq - NM_001355168
RefSeq - NM_001355169
RefSeq - NM_001355170
RefSeq - NM_001355171
RefSeq Peptide - NP_001342100
RefSeq Peptide - NP_001342098
RefSeq Peptide - NP_001342099
RefSeq Peptide - NP_061202
RefSeq Peptide - NP_001342097
swissprot - F6U9Y2
swissprot - A2ASI5
Ensembl - ENSMUSG00000057182
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn1aENSDARG00000086819Danio rerio
 scn1labENSDARG00000062744Danio rerio
 SCN3AENSGALG00000011040Gallus gallus
 SCN3AENSG00000153253Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scn2a / sodium channel, voltage-gated, type II, alpha / Q99250* / sodium voltage-gated channel alpha subunit 2*ENSMUSG0000007531887
Scn1a / A2APX8 / Sodium channel protein type 1 subunit alpha / P35498* / sodium voltage-gated channel alpha subunit 1*ENSMUSG0000006432985
Scn9a / Q62205 / Sodium channel protein type 9 subunit alpha / Q15858* / sodium voltage-gated channel alpha subunit 9*ENSMUSG0000007531677
Scn8a / sodium channel, voltage-gated, type VIII, alpha / Q9UQD0* / sodium voltage-gated channel alpha subunit 8*ENSMUSG0000002303375
Scn4a / sodium channel, voltage-gated, type IV, alpha / P35499* / sodium voltage-gated channel alpha subunit 4*ENSMUSG0000000102765
Scn5a / Q9JJV9 / Sodium channel protein type 5 subunit alpha / Q14524* / sodium voltage-gated channel alpha subunit 5*ENSMUSG0000003251164
Q6QIY3 / Scn10a / sodium channel, voltage-gated, type X, alpha / Q9Y5Y9* / sodium voltage-gated channel alpha subunit 10*ENSMUSG0000003453357
Q9R053 / Scn11a / Sodium channel protein type 11 subunit alpha / Q9UI33* / sodium voltage-gated channel alpha subunit 11*ENSMUSG0000003411547
Scn7a / sodium voltage-gated channel alpha subunit 7 / Q01118*ENSMUSG0000003481043
Cacna1h / voltage-dependent T-type calcium channel subunit alpha-1H isoform 2 / O95180* / calcium voltage-gated channel subunit alpha1 H*ENSMUSG0000002411224
Cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSMUSG0000002086624
Cacna1i / calcium channel, voltage-dependent, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I*ENSMUSG0000002241623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR024583  Voltage-gated Na+ ion channel, cytoplasmic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0019228 neuronal action potential IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IBA
 molecular_functionGO:0005272 sodium channel activity IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6m10Bei/Lrp6m10Bei
Genetic Background: involves: A/J * C57BL/6

Allelic Composition: Scn3atm1.2Jwo/Scn3atm1.2Jwo
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * BALB/c * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Csf1op/Csf1op
Genetic Background: C57BL/6J-Csf1op

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Baxtm1Dlo/Baxtm1Dlo,Bcl2l1tm1Dlo/Bcl2l1tm1Dlo
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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