MP:0000243 | myoclonus | "involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Grem1tm1Rmh/Grem1tm1Rmh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Scn8aM1Btlr/Scn8aM1Btlr Genetic Background: C57BL/6J-Scn8aM1Btlr
Allelic Composition: Scn8aM1Btlr/Scn8a+ Genetic Background: C57BL/6J-Scn8aM1Btlr
Allelic Composition: Scn8amed-J/Scn8amed-J Genetic Background: involves: STOCK Krt71Ca
Allelic Composition: Scn8amed-jo/Scn8amed-jo Genetic Background: DBA/2WyDi-Scn8amed-jo
Allelic Composition: Scn8anur14/Scn8anur14 Genetic Background: C57BL/6J-Scn8anur14
Allelic Composition: Scn8amed-TgA4Bs/Scn8anur14 Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8am10J/Scn8am10J Genetic Background: FVB/NJ-Scn8am10J/GrsrCx
Allelic Composition: Scn8am3Btlr/Scn8am3Btlr Genetic Background: C57BL/6J-Scn8am3Btlr
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: BALB/cJ-Scn8a9J/GrsrJ
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0000747 | muscle weakness | "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J * STOCK Krt71Ca
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0000748 | progressive muscle weakness | "increasing loss of strength over time" [MGI:CLS, J:67994] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0000749 | muscle degeneration | "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
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MP:0000751 | myopathy | "any abnormal condition or disease of the skeletal muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42574] |
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Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0000752 | dystrophic muscle | "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Scn8admu/Scn8amed Genetic Background: involves: C3H * C3HeB/Fe * C57BL/6
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MP:0000753 | paralysis | "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J
Allelic Composition: Scn8am10J/Scn8am10J Genetic Background: FVB/NJ-Scn8am10J/GrsrCx
Allelic Composition: Scn8am11J/Scn8am11J Genetic Background: B6.Cg-Scn8am11J/GrsrJ
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MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
Allelic Composition: Scn8a4J/Scn8a4J Genetic Background: C57BL/6J-Scn8a4J/J
Allelic Composition: Scn8a5J/Scn8a5J Genetic Background: C57BL/6J-Scn8a5J/J
Allelic Composition: Scn8a6J/Scn8a6J Genetic Background: C57BL/6J-Scn8a6J/J
Allelic Composition: Scn8anur14/Scn8anur14 Genetic Background: involves: C57BL/6J
Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1tm1.1Mm/Scnm1tm1.1Mm Genetic Background: involves: C57BL/6 * FVB * SJL * STOCK Krt71Ca
Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Scn8admu/Scn8amed Genetic Background: involves: C3H * C3HeB/Fe * C57BL/6
Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Scn8anur14/Scn8anur14 Genetic Background: C57BL/6J-Scn8anur14
Allelic Composition: Scn8am2Btlr/Scn8am2Btlr Genetic Background: C57BL/6J-Scn8am2Btlr
Allelic Composition: Scn8am11J/Scn8am11J Genetic Background: B6.Cg-Scn8am11J/GrsrJ
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MP:0000852 | small cerebellum | "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0000872 | abnormal external granule cell layer | "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0000876 | Purkinje cell degeneration | "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854] |
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J Genetic Background: B6(129S7)-Scn8amed-jo2J/J
Allelic Composition: Scn8amed-jo/Scn8amed-jo Genetic Background: DBA/2WyDi-Scn8amed-jo
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MP:0000880 | decreased Purkinje cell number | "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0000921 | demyelination | "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0000940 | abnormal motor neuron innervation | "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
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Allelic Composition: Cdkn2atm1Cjs/Cdkn2atm1Cjs,Pax7tm1Pgr/Pax7+,Tg(CKMM-tTA)A3Rhvh/0,Tg(tetO-Hgf,-EGFP)24Tcre/0 Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * FVB
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MP:0000958 | peripheral nervous system degeneration | "a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0001053 | abnormal neuromuscular synapse | "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
Allelic Composition: GarsC201R/Gars+,Scn8am10J/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeJ * FVB/NJ
Allelic Composition: GarsNmf249/Gars+,Scn8am10J/Scn8a+ Genetic Background: involves: C57BL/6J * FVB/NJ
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Scn8a6J/Scn8a6J Genetic Background: C57BL/6J-Scn8a6J/J
Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8am3Btlr/Scn8am3Btlr Genetic Background: C57BL/6J-Scn8am3Btlr
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo Genetic Background: Not Specified
Allelic Composition: Scn8a8J/Scn8a8J Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Scn8am10J/Scn8am10J Genetic Background: FVB/NJ-Scn8am10J/GrsrCx
Allelic Composition: Scn8am11J/Scn8am11J Genetic Background: B6.Cg-Scn8am11J/GrsrJ
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MP:0001363 | increased anxiety-related response | "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060] |
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Allelic Composition: Celsr1tm1Fati/Celsr1tm1Fati,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
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MP:0001392 | abnormal locomotor activity | "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8a8J/Scn8a8J Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0001393 | ataxia | "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231] |
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Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J
Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
Allelic Composition: Scn8amed-J/Scn8amed-J Genetic Background: involves: STOCK Krt71Ca
Allelic Composition: Scn8anur14/Scn8anur14 Genetic Background: C57BL/6J-Scn8anur14
Allelic Composition: Scn8amed-TgA4Bs/Scn8anur14 Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Scn8am10J/Scn8am10J Genetic Background: FVB/NJ-Scn8am10J/GrsrCx
Allelic Composition: Scn8am3Btlr/Scn8am3Btlr Genetic Background: C57BL/6J-Scn8am3Btlr
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
Allelic Composition: Scn8am11J/Scn8am11J Genetic Background: B6.Cg-Scn8am11J/GrsrJ
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MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Scn8a6J/Scn8a6J Genetic Background: C57BL/6J-Scn8a6J/J
Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J Genetic Background: B6(129S7)-Scn8amed-jo2J/J
Allelic Composition: Scn8aM1Btlr/Scn8aM1Btlr Genetic Background: C57BL/6J-Scn8aM1Btlr
Allelic Composition: Scn8aM1Btlr/Scn8a+ Genetic Background: C57BL/6J-Scn8aM1Btlr
Allelic Composition: Scn8amed-J/Scn8amed-J Genetic Background: involves: STOCK Krt71Ca
Allelic Composition: Scn8a8J/Scn8a8J Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0001485 | abnormal pinna reflex | "failure to respond to an auditory stimulus by a characteristic ear twitch " [J:64900] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/c
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MP:0001489 | decreased startle reflex | "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0001492 | piloerection | "the involuntary bristling of hairs" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Celsr1tm1Fati/Celsr1tm1Fati,Emx1tm1(cre)Krj/Emx1+ Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0001504 | abnormal posture | "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984] |
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Allelic Composition: Klk1b1tm1Pmtn/Klk1b1tm1Pmtn Genetic Background: involves: 129/Sv * C57BL/6
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MP:0001505 | hunched posture | "stooped low with the limbs pulled in close to the body and arched back" [J:67231, J:30404] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Klk1b1tm1Pmtn/Klk1b1tm1Pmtn Genetic Background: involves: 129/Sv * C57BL/6
Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs Genetic Background: involves: C3H * C57BL/6J
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MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: BALB/cJ-Scn8a9J/GrsrJ
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MP:0001524 | impaired limb coordination | "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123] |
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Allelic Composition: Scn8amed-jo/Scn8amed-jo Genetic Background: DBA/2WyDi-Scn8amed-jo
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MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
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Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs Genetic Background: involves: C3H * C57BL/6J
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MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Scn8a5J/Scn8a5J Genetic Background: C57BL/6J-Scn8a5J/J
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MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
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MP:0001961 | abnormal reflex | "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0002064 | seizures | "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Stat4ity14/Stat4ity14 Genetic Background: involves: 129S1/Sv * 129X1/SvJ
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MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Zdhhc8tm1Kara/Zdhhc8+ Genetic Background: Not Specified
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1m1R/Scnm1m1R Genetic Background: involves: C57BL/6 * STOCK Krt71Ca
Allelic Composition: Scn8admu/Scn8amed Genetic Background: involves: C3H * C3HeB/Fe * C57BL/6
Allelic Composition: Scn8a8J/Scn8a8J Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Scn8amed-TgA4Bs/Scn8anur14 Genetic Background: involves: C3H * C57BL/6J
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Atoh1tm2Hzo/Atoh1tm2Hzo Genetic Background: Not Specified
Allelic Composition: Scn8a6J/Scn8a6J Genetic Background: C57BL/6J-Scn8a6J/J
Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J
Allelic Composition: Scn8atm1Mm/Scn8atm1Mm,Tg(Zp3-cre)3Mrt/? Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1tm1.1Mm/Scnm1tm1.1Mm Genetic Background: involves: C57BL/6 * FVB * SJL * STOCK Krt71Ca
Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J * STOCK Krt71Ca
Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs Genetic Background: involves: C3H * C57BL/6J
Allelic Composition: Scn8a8J/Scn8a8J Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Scn8anur14/Scn8anur14 Genetic Background: C57BL/6J-Scn8anur14
Allelic Composition: Scn8aem1Mm/Scn8a+ Genetic Background: involves: C57BL/6J * SJL
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: BALB/cJ-Scn8a9J/GrsrJ
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0002106 | abnormal muscle physiology | "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Nodaltm2Rob/Nodaltm2Rob Genetic Background: involves: 129S/SvEv * ICR
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MP:0002269 | muscular atrophy | "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
Allelic Composition: Scn8a6J/Scn8a6J Genetic Background: C57BL/6J-Scn8a6J/J
Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J
Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs Genetic Background: involves: C3H * C57BL/6J
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MP:0002272 | abnormal nervous system electrophysiology | "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Scn8amed-jo/Scn8amed-jo Genetic Background: DBA/2WyDi-Scn8amed-jo
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MP:0002687 | oligozoospermia | "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312] |
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J Genetic Background: B6(129S7)-Scn8amed-jo2J/J
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MP:0002887 | resistance to pharmacologically induced seizures | "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284] |
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Allelic Composition: Scn8amed-jo/Scn8amed-jo Genetic Background: DBA/2WyDi-Scn8amed-jo
Allelic Composition: Scn8amed-jo/Scn8a+ Genetic Background: B6.D2-Scn8amed-jo/J
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MP:0002914 | abnormal endplate potential activity | "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0003157 | impaired muscle relaxation | "reduced or absent ability of muscle to lengthen following contractions" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92510] |
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Allelic Composition: Scn8am11J/Scn8am11J Genetic Background: B6.Cg-Scn8am11J/GrsrJ
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MP:0003491 | abnormal voluntary movement | "anomalies in coordinated movements executed with a purpose and can be improved by learning and/or experience" [Nmice:Neuromice Consortium Submission] |
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Allelic Composition: Scn8admu/Scn8amed Genetic Background: involves: C3H * C3HeB/Fe * C57BL/6
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MP:0003852 | skeletal muscle necrosis | "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
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MP:0003993 | abnormal ventral spinal root morphology | "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0004142 | abnormal muscle tone | "anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0004566 | myocardial fiber degeneration | "deterioration or destruction of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
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MP:0004709 | cervical vertebrae degeneration | "retrogressive pathologic change of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J Genetic Background: B6(129S7)-Scn8amed-jo2J/J
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MP:0004811 | abnormal neuron physiology | "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings] |
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Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0004835 | abnormal miniature endplate potential | "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aem1Mm/Scn8a+ Genetic Background: involves: C57BL/6J * SJL
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MP:0005294 | abnormal heart ventricle morphology | "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
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MP:0005307 | head tossing | "compulsive flailing of the head in multiple directions" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0005323 | dystonia | "impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs" [J:84533] |
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Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J
Allelic Composition: Scn8amed-J/Scn8amed-J Genetic Background: involves: STOCK Krt71Ca
Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0005402 | abnormal action potential | "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0005403 | abnormal nerve conduction | "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0005405 | axon degeneration | "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J Genetic Background: B6(129S7)-Scn8amed-jo2J/J
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MP:0005551 | abnormal eye electrophysiology | "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator] |
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Allelic Composition: Fgf8tm1.3Mrt/Fgf8tm1.4Mrt,Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor,Nkx2-5tm1(cre)Rjs/Nkx2-5+ Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6 * DBA/2J
Allelic Composition: Scn8amed/Scn8amed Genetic Background: involves: C3HeB/FeJ * DBA/2J
Allelic Composition: Scn8amed-TgA4Bs/Scn8amed-TgA4Bs Genetic Background: B6.Cg-Scn8amed-TgA4Bs
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MP:0005621 | abnormal cell physiology | "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1tm1.1Mm/Scnm1tm1.1Mm Genetic Background: involves: C57BL/6 * FVB * SJL * STOCK Krt71Ca
Allelic Composition: Scn8amed-J/Scn8amed-J,Scnm1s/Scnm1s Genetic Background: involves: C57BL/6J * STOCK Krt71Ca
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MP:0006113 | abnormal heart septum morphology | "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
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MP:0006325 | impaired hearing | "reduced ability to percieve auditory stimuli" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0006358 | absent pinna reflex | "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Kcnq2Nmf134/Kcnq2+,Scn1atm1.1Aesc/Scn1a+ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
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MP:0008814 | reduced nerve conduction velocity | "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
Allelic Composition: GarsC201R/Gars+,Scn8am10J/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeJ * FVB/NJ
Allelic Composition: Scn8am10J/Scn8a+ Genetic Background: FVB/NJ-Scn8am10J/GrsrCx
Allelic Composition: GarsNmf249/Gars+,Scn8am10J/Scn8a+ Genetic Background: involves: C57BL/6J * FVB/NJ
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MP:0008840 | abnormal spike wave discharge | "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200] |
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Allelic Composition: Scn8amed-jo/Scn8amed-jo Genetic Background: DBA/2WyDi-Scn8amed-jo
Allelic Composition: Scn8amed-jo/Scn8a+ Genetic Background: B6.D2-Scn8amed-jo/J
Allelic Composition: Scn1atm1Wac/Scn1a+,Scn8amed-jo/Scn8a+ Genetic Background: involves: 129 * C57BL/6J * DBA/2WyDi * FVB/NJ
Allelic Composition: Scn8a8J/Scn8a8J Genetic Background: involves: C3HeB/FeJ * C57BL/6J
Allelic Composition: Scn8a8J/Scn8a+ Genetic Background: involves: C3HeB/FeJ * C57BL/6J
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MP:0008924 | decreased granule neuron number | "reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"] |
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Allelic Composition: Scn8a5J/Scn8a5J Genetic Background: C57BL/6J-Scn8a5J/J
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MP:0009400 | decreased skeletal muscle fiber size | "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8a7J/Scn8a7J Genetic Background: involves: BALB/cByJ * C57BL/6J
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MP:0009417 | skeletal muscle atrophy | "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: GarsNmf249/Gars+,Scn8am10J/Scn8a+ Genetic Background: involves: C57BL/6J * FVB/NJ
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MP:0009434 | paraparesis | "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Hps5ru2-r/Hps5ru2-r Genetic Background: C57BL/10
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MP:0009779 | enhanced behavioral response to anesthetic | "increase or exceleration in the behavioral changes that follow exposure to a given amount of an anesthetizing agent" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
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Allelic Composition: Scn8a9J/Scn8a9J Genetic Background: B6J.C-Scn8a9J/Mm
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MP:0010492 | abnormal atrium endocardium morphology | "any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the atria" [MESH:A07.541.207] |
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Allelic Composition: Scn8admu/Scn8admu Genetic Background: involves: C3H * C57BL/6
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MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Scn8a5J/Scn8a5J Genetic Background: C57BL/6J-Scn8a5J/J
Allelic Composition: Scn8anur14/Scn8anur14 Genetic Background: involves: C57BL/6J
Allelic Composition: Scn1atm1Wac/Scn1atm1Wac,Scn8amed-jo/Scn8a+ Genetic Background: involves: 129 * C57BL/6J * DBA/2WyDi * FVB/NJ
Allelic Composition: Scn8am10J/Scn8am10J Genetic Background: FVB/NJ-Scn8am10J/GrsrCx
Allelic Composition: Scn8am11J/Scn8am11J Genetic Background: B6.Cg-Scn8am11J/GrsrJ
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J Genetic Background: B6(129S7)-Scn8amed-jo2J/J
Allelic Composition: Scn1atm1.1Aesc/Scn1atm1.1Aesc,Scn8amed-jo/Scn8a+ Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * DBA/2WyDi
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MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: Scn8a5J/Scn8a5J Genetic Background: C57BL/6J-Scn8a5J/J
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MP:0011966 | abnormal auditory brainstem response waveform shape | "any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts" [MGI:csmith] |
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Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
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MP:0011967 | increased or absent threshold for auditory brainstem response | "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith] |
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Allelic Composition: Scn8amed-jo2J/Scn8amed-jo2J Genetic Background: B6(129S7)-Scn8amed-jo2J/J
Allelic Composition: Scn8aClth/Scn8aClth Genetic Background: involves: BALB/cAnN * C3H/HeH
Allelic Composition: Scn8aClth/Scn8a+ Genetic Background: involves: BALB/cAnN * C3H/HeH
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