ENSMUSG00000024112


Mus musculus

Features
Gene ID: ENSMUSG00000024112
  
Biological name :Cacna1h
  
Synonyms : Cacna1h / voltage-dependent T-type calcium channel subunit alpha-1H isoform 2
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 H / O95180
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: A3.3
Gene start: 25374285
Gene end: 25433783
  
Corresponding Affymetrix probe sets: 10448925 (MoGene1.0st)   1422710_a_at (Mouse Genome 430 2.0 Array)   1427607_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124883
Ensembl peptide - ENSMUSP00000123906
Ensembl peptide - ENSMUSP00000125541
Ensembl peptide - ENSMUSP00000125664
Ensembl peptide - ENSMUSP00000077586
Ensembl peptide - ENSMUSP00000123741
NCBI entrez gene - 58226     See in Manteia.
MGI - MGI:1928842
RefSeq - XM_011246555
RefSeq - NM_001163691
RefSeq - NM_021415
RefSeq - XM_006524733
RefSeq - XM_006524734
RefSeq Peptide - NP_067390
RefSeq Peptide - NP_001157163
swissprot - F6U5P7
swissprot - F6USE5
swissprot - E9Q6E4
swissprot - E9Q6P9
swissprot - E0CYZ3
Ensembl - ENSMUSG00000024112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1haENSDARG00000060496Danio rerio
 cacna1hbENSDARG00000099708Danio rerio
 CACNA1HENSGALG00000005215Gallus gallus
 O95180ENSG00000196557Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSMUSG0000002086655
Cacna1i / calcium channel, voltage-dependent, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I*ENSMUSG0000002241652
Scn8a / sodium channel, voltage-gated, type VIII, alpha / Q9UQD0* / sodium voltage-gated channel alpha subunit 8*ENSMUSG0000002303321
Scn2a / sodium channel, voltage-gated, type II, alpha / Q99250* / sodium voltage-gated channel alpha subunit 2*ENSMUSG0000007531821
Scn1a / A2APX8 / Sodium channel protein type 1 subunit alpha / P35498* / sodium voltage-gated channel alpha subunit 1*ENSMUSG0000006432921
Scn9a / Q62205 / Sodium channel protein type 9 subunit alpha / Q15858* / sodium voltage-gated channel alpha subunit 9*ENSMUSG0000007531621
Scn3a / sodium channel, voltage-gated, type III, alpha / Q9NY46* / sodium voltage-gated channel alpha subunit 3*ENSMUSG0000005718220
Scn5a / Q9JJV9 / Sodium channel protein type 5 subunit alpha / Q14524* / sodium voltage-gated channel alpha subunit 5*ENSMUSG0000003251120
Scn4a / sodium channel, voltage-gated, type IV, alpha / P35499* / sodium voltage-gated channel alpha subunit 4*ENSMUSG0000000102719
Q6QIY3 / Scn10a / sodium channel, voltage-gated, type X, alpha / Q9Y5Y9* / sodium voltage-gated channel alpha subunit 10*ENSMUSG0000003453319
Q9R053 / Scn11a / Sodium channel protein type 11 subunit alpha / Q9UI33* / sodium voltage-gated channel alpha subunit 11*ENSMUSG0000003411518
Scn7a / sodium voltage-gated channel alpha subunit 7 / Q01118*ENSMUSG0000003481015


Protein motifs (from Interpro)
Interpro ID Name
 IPR005445  Voltage-dependent calcium channel, T-type, alpha-1 subunit
 IPR005821  Ion transport domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0032342 aldosterone biosynthetic process IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034651 cortisol biosynthetic process IEA
 biological_processGO:0035865 cellular response to potassium ion IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070509 calcium ion import IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0098662 inorganic cation transmembrane transport IEA
 biological_processGO:2000344 positive regulation of acrosome reaction IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0008332 low voltage-gated calcium channel activity IEA
 molecular_functionGO:0097110 scaffold protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0003120 abnormal tracheal cartilage "any structural anomaly of the cartilaginous structures that support the trachea" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:97123]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0004112 abnormal arteriole morphology "structural anomaly in the small diameter vessels that branch from the arteries and lead to the capillaries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitlSl-20J/KitlSl-20J
Genetic Background: C57BL/6J-KitlSl-20J/J

 MP:0010883 trachea stenosis "abnormal narrowing or constriction of the trachea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkdcscid/Prkdcscid,Tg(INS-HBEGF*L148S*P149T)70Rin/0
Genetic Background: CB17/lcr-Prkdcscid Tg(INS-HBEGF*L148S*P149T)70Rin

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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