ENSMUSG00000034115


Mus musculus

Features
Gene ID: ENSMUSG00000034115
  
Biological name :Scn11a
  
Synonyms : Q9R053 / Scn11a / Sodium channel protein type 11 subunit alpha
  
Possible biological names infered from orthology : Q9UI33 / sodium voltage-gated channel alpha subunit 11
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: F3
Gene start: 119753759
Gene end: 119825456
  
Corresponding Affymetrix probe sets: 10597714 (MoGene1.0st)   1420784_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000065466
Ensembl peptide - ENSMUSP00000149420
NCBI entrez gene - 24046     See in Manteia.
MGI - MGI:1345149
RefSeq - XM_017313362
RefSeq - NM_011887
RefSeq Peptide - NP_036017
swissprot - Q9R053
Ensembl - ENSMUSG00000034115
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scn12aaENSDARG00000090724Danio rerio
 scn12abENSDARG00000102312Danio rerio
 SCN11AENSGALG00000027702Gallus gallus
 Q9UI33ENSG00000168356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scn5a / Q9JJV9 / Sodium channel protein type 5 subunit alpha / Q14524* / sodium voltage-gated channel alpha subunit 5*ENSMUSG0000003251154
Q6QIY3 / Scn10a / sodium channel, voltage-gated, type X, alpha / Q9Y5Y9* / sodium voltage-gated channel alpha subunit 10*ENSMUSG0000003453353
Scn2a / sodium channel, voltage-gated, type II, alpha / Q99250* / sodium voltage-gated channel alpha subunit 2*ENSMUSG0000007531852
Scn9a / Q62205 / Sodium channel protein type 9 subunit alpha / Q15858* / sodium voltage-gated channel alpha subunit 9*ENSMUSG0000007531652
Scn1a / A2APX8 / Sodium channel protein type 1 subunit alpha / P35498* / sodium voltage-gated channel alpha subunit 1*ENSMUSG0000006432952
Scn3a / sodium channel, voltage-gated, type III, alpha / Q9NY46* / sodium voltage-gated channel alpha subunit 3*ENSMUSG0000005718251
Scn8a / sodium channel, voltage-gated, type VIII, alpha / Q9UQD0* / sodium voltage-gated channel alpha subunit 8*ENSMUSG0000002303351
Scn4a / sodium channel, voltage-gated, type IV, alpha / P35499* / sodium voltage-gated channel alpha subunit 4*ENSMUSG0000000102749
Scn7a / sodium voltage-gated channel alpha subunit 7 / Q01118*ENSMUSG0000003481036
Cacna1i / calcium channel, voltage-dependent, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I*ENSMUSG0000002241623
Cacna1h / voltage-dependent T-type calcium channel subunit alpha-1H isoform 2 / O95180* / calcium voltage-gated channel subunit alpha1 H*ENSMUSG0000002411223
Cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSMUSG0000002086623


Protein motifs (from Interpro)
Interpro ID Name
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR028821  Voltage gated sodium channel, alpha-11 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IDA
 biological_processGO:0019228 neuronal action potential IBA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0051930 regulation of sensory perception of pain IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0086010 membrane depolarization during action potential IBA
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0044299 C-fiber IDA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IDA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Scarb1tm1Kri/Scarb1tm1Kri
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Scn10atm1Lex/Scn10atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: EdaTa/Y,Tnfrsf19Gt(OST294987)Lex/Tnfrsf19Gt(OST294987)Lex
Genetic Background: involves: 129S5/SvEvBrd * A * C57BL/6 * CBA/CaGnLe

Allelic Composition: Scn11atm1.1Ikth/Scn11a+
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Scn11atm1Mdba/Scn11atm1Mdba
Genetic Background: Not Specified

Allelic Composition: Scn11atm1Mdba/Scn11atm1.1Ikth
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn10atm1Lex/Scn10atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Icam1tm1Bay/Icam1tm1Bay
Genetic Background: B6.129S7-Icam1tm1Bay

Allelic Composition: Scn11atm1Dgen/Scn11a+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Scn11atm1Wlf/Scn11atm1Wlf
Genetic Background: B6.Cg-Scn11atm1Wlf

Allelic Composition: Scn11atm1Lex/Scn11atm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

Allelic Composition: Scn11atm1.1Ikth/Scn11a+
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
Show

Allelic Composition: Scn11atm1.1Ikth/Scn11a+
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Scn11atm1Wlf/Scn11atm1Wlf
Genetic Background: B6.Cg-Scn11atm1Wlf

Allelic Composition: Scn11atm1Gsk/Scn11atm1Gsk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003484 abnormal channel response "anomalies in the electrophysiological recordings from ion channels" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Scn11atm1.1Ikth/Scn11a+
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Scn11atm1Mdba/Scn11atm1.1Ikth
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Scn11atm1.1Ikth/Scn11a+
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Scn11atm1.1Ikth/Scn11a+
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Scn11atm1Mdba/Scn11atm1Mdba
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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