ENSMUSG00000020866


Mus musculus

Features
Gene ID: ENSMUSG00000020866
  
Biological name :Cacna1g
  
Synonyms : Cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit
  
Possible biological names infered from orthology : calcium voltage-gated channel subunit alpha1 G / O43497
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 94408391
Gene end: 94474198
  
Corresponding Affymetrix probe sets: 10389929 (MoGene1.0st)   1423365_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103422
Ensembl peptide - ENSMUSP00000103420
Ensembl peptide - ENSMUSP00000103421
Ensembl peptide - ENSMUSP00000021234
Ensembl peptide - ENSMUSP00000098127
Ensembl peptide - ENSMUSP00000099455
Ensembl peptide - ENSMUSP00000103414
Ensembl peptide - ENSMUSP00000103415
Ensembl peptide - ENSMUSP00000103417
Ensembl peptide - ENSMUSP00000103418
Ensembl peptide - ENSMUSP00000103419
NCBI entrez gene - 12291     See in Manteia.
MGI - MGI:1201678
RefSeq - XM_017314235
RefSeq - NM_001112813
RefSeq - NM_001177888
RefSeq - NM_001177890
RefSeq - NM_009783
RefSeq - XM_011248687
RefSeq - XM_011248688
RefSeq - XM_011248689
RefSeq - XM_011248690
RefSeq - XM_011248691
RefSeq - XM_011248692
RefSeq - XM_011248693
RefSeq - XM_011248694
RefSeq - XM_011248695
RefSeq - XM_011248696
RefSeq - XM_011248697
RefSeq - XM_011248698
RefSeq - XM_011248699
RefSeq - XM_011248700
RefSeq - XM_017314234
RefSeq - XM_006532069
RefSeq - XM_006532070
RefSeq - XM_006532072
RefSeq - XM_006532073
RefSeq - XM_006532074
RefSeq - XM_006532075
RefSeq - XM_006532076
RefSeq - XM_006532079
RefSeq - XM_006532080
RefSeq - XM_006532081
RefSeq - XM_006532082
RefSeq - XM_006532083
RefSeq - XM_006532084
RefSeq - XM_006532085
RefSeq - XM_006532086
RefSeq - XM_006532087
RefSeq - XM_006532088
RefSeq - XM_011248686
RefSeq Peptide - NP_001106284
RefSeq Peptide - NP_001171359
RefSeq Peptide - NP_001171361
RefSeq Peptide - NP_033913
swissprot - Q5SUF5
swissprot - Q5SUF6
swissprot - Q5SUF7
swissprot - Q5SUF8
swissprot - Q5SUF9
swissprot - Q5SUG0
swissprot - Q5SUG1
swissprot - Q5SUG2
swissprot - Q5SUG3
swissprot - Q5SUG4
swissprot - E9PWL1
Ensembl - ENSMUSG00000020866
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cacna1gENSDARG00000089913Danio rerio
 CACNA1GENSGALG00000007623Gallus gallus
 O43497ENSG00000006283Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cacna1h / voltage-dependent T-type calcium channel subunit alpha-1H isoform 2 / O95180* / calcium voltage-gated channel subunit alpha1 H*ENSMUSG0000002411257
Cacna1i / calcium channel, voltage-dependent, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I*ENSMUSG0000002241649
Scn2a / sodium channel, voltage-gated, type II, alpha / Q99250* / sodium voltage-gated channel alpha subunit 2*ENSMUSG0000007531821
Scn9a / Q62205 / Sodium channel protein type 9 subunit alpha / Q15858* / sodium voltage-gated channel alpha subunit 9*ENSMUSG0000007531621
Scn1a / A2APX8 / Sodium channel protein type 1 subunit alpha / P35498* / sodium voltage-gated channel alpha subunit 1*ENSMUSG0000006432921
Scn5a / Q9JJV9 / Sodium channel protein type 5 subunit alpha / Q14524* / sodium voltage-gated channel alpha subunit 5*ENSMUSG0000003251120
Scn8a / sodium channel, voltage-gated, type VIII, alpha / Q9UQD0* / sodium voltage-gated channel alpha subunit 8*ENSMUSG0000002303320
Scn3a / sodium channel, voltage-gated, type III, alpha / Q9NY46* / sodium voltage-gated channel alpha subunit 3*ENSMUSG0000005718220
Q6QIY3 / Scn10a / sodium channel, voltage-gated, type X, alpha / Q9Y5Y9* / sodium voltage-gated channel alpha subunit 10*ENSMUSG0000003453319
Scn4a / sodium channel, voltage-gated, type IV, alpha / P35499* / sodium voltage-gated channel alpha subunit 4*ENSMUSG0000000102719
Q9R053 / Scn11a / Sodium channel protein type 11 subunit alpha / Q9UI33* / sodium voltage-gated channel alpha subunit 11*ENSMUSG0000003411518
Scn7a / sodium voltage-gated channel alpha subunit 7 / Q01118*ENSMUSG0000003481015


Protein motifs (from Interpro)
Interpro ID Name
 IPR002077  Voltage-dependent calcium channel, alpha-1 subunit
 IPR005445  Voltage-dependent calcium channel, T-type, alpha-1 subunit
 IPR005821  Ion transport domain
 IPR030154  Voltage-dependent calcium channel, T-type, alpha-1G subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001508 action potential IMP
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007268 chemical synaptic transmission IGI
 biological_processGO:0010045 response to nickel cation IMP
 biological_processGO:0019228 neuronal action potential IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential ISO
 biological_processGO:0045956 positive regulation of calcium ion-dependent exocytosis IBA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0060371 regulation of atrial cardiac muscle cell membrane depolarization IMP
 biological_processGO:0070509 calcium ion import ISO
 biological_processGO:0070588 calcium ion transmembrane transport ISO
 biological_processGO:0086002 cardiac muscle cell action potential involved in contraction IMP
 biological_processGO:0086015 SA node cell action potential IMP
 biological_processGO:0086016 AV node cell action potential IMP
 biological_processGO:0086018 SA node cell to atrial cardiac muscle cell signaling IMP
 biological_processGO:0086027 AV node cell to bundle of His cell signaling IMP
 biological_processGO:0086045 membrane depolarization during AV node cell action potential IMP
 biological_processGO:0086046 membrane depolarization during SA node cell action potential IMP
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IMP
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IDA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IBA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008332 low voltage-gated calcium channel activity ISO
 molecular_functionGO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential IMP
 molecular_functionGO:0086059 voltage-gated calcium channel activity involved SA node cell action potential IMP
 molecular_functionGO:0097110 scaffold protein binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ins2Akita/Ins2Akita,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: B6.Cg-Ins2Akita Ldlrtm1Her

Allelic Composition: Cacna1gtm1Hssh/Cacna1gtm1Hssh
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Cacna1gtm1Hssh/Cacna1gtm1Hssh,Gabra1tm1.1Geh/Gabra1tm1.1Geh
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: B4galnt1tm1Rlp/B4galnt1tm1Rlp,St8sia1tm1Rlp/St8sia1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1gtm1Hssh/Cacna1gtm1Hssh,Gabra1tm1.1Geh/Gabra1tm1.1Geh
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

Allelic Composition: Cacna1gtm1Hssh/Cacna1gtm1Hssh
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

Allelic Composition: Cacna1gtm1Stl/Cacna1gtm1Stl,Tg(Kcnc2-cre)K128Stl/0
Genetic Background: involves: C57BL/6

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002578 impaired ability to fire action potentials "anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs" [J:51377, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hmgb1tm1Meb/Hmgb1tm1Meb
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Cacna1gtm1Hssh/Cacna1gtm1Hssh,Gabra1tm1.1Geh/Gabra1tm1.1Geh
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0002887 resistance to pharmacologically induced seizures "ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:77284]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

Allelic Composition: Cacna1gtm1.1Stl/Cacna1gtm1.1Stl
Genetic Background: involves: C57BL/6

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: B4galnt1tm1Rlp/B4galnt1tm1Rlp,St8sia1tm1Rlp/St8sia1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac

 MP:0006141 abnormal atrioventricular node conduction "anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle " [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
Show

Allelic Composition: Cyp19a1tm1Sih/Cyp19a1tm1Sih
Genetic Background: involves: 129S/SvEv

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1gtm1Hssh/Cacna1gtm1Hssh,Gabra1tm1.1Geh/Gabra1tm1.1Geh
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6J

 MP:0009747 impaired behavioral response to xenobiotic "decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf1atm1Blt/Tnfrsf1atm1Blt
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0011953 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
Show

Allelic Composition: Ccm2Gt(RRG051)Byg/Ccm2Gt(RRG051)Byg
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr