ENSDARG00000090724


Danio rerio

Features
Gene ID: ENSDARG00000090724
  
Biological name :scn12aa
  
Synonyms : scn12aa / sodium channel, voltage gated, type XII, alpha a
  
Possible biological names infered from orthology : Q14524 / Q6QIY3 / Q9JJV9 / Q9R053 / Q9UI33 / Q9Y5Y9 / SCN10A / SCN11A / SCN5A / Sodium channel protein type 11 subunit alpha / Sodium channel protein type 5 subunit alpha / sodium channel, voltage-gated, type X, alpha / sodium voltage-gated channel alpha subunit 10 / sodium voltage-gated channel alpha subunit 11 / sodium voltage-gated channel alpha subunit 5
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 51888033
Gene end: 52020049
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000107413
Ensembl peptide - ENSDARP00000113912
NCBI entrez gene - 795688     See in Manteia.
RefSeq - NM_001044922
RefSeq Peptide - NP_001038387
swissprot - F1R3Q5
swissprot - A8WHR2
ZFIN ID - ZDB-GENE-060908-2
Ensembl - ENSDARG00000090724
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000006072Gallus gallus
 SCN11AENSGALG00000027702Gallus gallus
 SCN5AENSGALG00000006112Gallus gallus
 Q9UI33ENSG00000168356Homo sapiens
 Q9Y5Y9ENSG00000185313Homo sapiens
 SCN5AENSG00000183873Homo sapiens
 Q6QIY3ENSMUSG00000034533Mus musculus
 Q9R053ENSMUSG00000034115Mus musculus
 Scn5aENSMUSG00000032511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
scn12ab / sodium channel, voltage gated, type XII, alpha b / SCN5A* / Q9R053* / Q9UI33* / Q9Y5Y9* / SCN10A* / SCN11A* / Q14524* / Q6QIY3* / Q9JJV9* / Sodium channel protein type 5 subunit a...ENSDARG0000010231278
scn1lab / sodium channel, voltage-gated, type I like, alpha b / SCN1A* / SCN9A* / SCN7A* / SCN2A* / SCN3A* / A2APX8* / P35498* / Q01118* / Q15858* / Q62205* / Q99250* / Q9NY46* / sodium vol...ENSDARG0000006274466
scn8ab / sodium channel, voltage gated, type VIII, alpha subunit b / SCN8A* / Q9UQD0* / sodium voltage-gated channel alpha subunit 8* / sodium channel, voltage-gated, type VIII, alpha*ENSDARG0000001803263
scn8aa / sodium channel, voltage gated, type VIII, alpha subunit a / SCN8A* / Q9UQD0* / sodium voltage-gated channel alpha subunit 8* / sodium channel, voltage-gated, type VIII, alpha*ENSDARG0000000577563
scn1a / sodium channel, voltage-gated, type I, alpha / SCN9A* / SCN3A* / SCN2A* / SCN7A* / A2APX8* / P35498* / Q01118* / Q15858* / Q62205* / Q99250* / Q9NY46* / sodium voltage-gated channel...ENSDARG0000008681961
scn4aa / sodium channel, voltage-gated, type IV, alpha, a / SCN4A* / P35499* / sodium voltage-gated channel alpha subunit 4* / sodium channel, voltage-gated, type IV, alpha*ENSDARG0000009873858
scn4ab / sodium channel, voltage-gated, type IV, alpha, b / SCN4A* / P35499* / sodium voltage-gated channel alpha subunit 4* / sodium channel, voltage-gated, type IV, alpha*ENSDARG0000003458858
cacna1ha / calcium channel, voltage-dependent, T type, alpha 1H subunit a / O95180* / CACNA1H* / calcium voltage-gated channel subunit alpha1 H* / voltage-dependent T-type calcium channel s...ENSDARG0000006049623
cacna1g / calcium channel, voltage-dependent, T type, alpha 1G subunit / O43497* / calcium voltage-gated channel subunit alpha1 G*ENSDARG0000008991323
cacna1i / calcium channel, voltage-dependent, T type, alpha 1I subunit / Q9P0X4* / calcium voltage-gated channel subunit alpha1 I* / calcium channel, voltage-dependent, alpha 1I subunit*ENSDARG0000007052222
cacna1hb / calcium channel, voltage-dependent, T type, alpha 1H subunit b / O95180* / CACNA1H* / calcium voltage-gated channel subunit alpha1 H* / voltage-dependent T-type calcium channel s...ENSDARG0000009970819
si:ch73-379f7.5 / CACNA1I (1 of many) / Q9P0X4* / CACNA1I* / calcium voltage-gated channel subunit alpha1 I* / calcium channel, voltage-dependent, alpha 1I subunit*ENSDARG0000009630710
LO017974.1 / Q9P0X4* / CACNA1I* / calcium voltage-gated channel subunit alpha1 I*ENSDARG000001157415


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001696  Voltage gated sodium channel, alpha subunit
 IPR005821  Ion transport domain
 IPR010526  Sodium ion transport-associated
 IPR024583  Voltage-gated Na+ ion channel, cytoplasmic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003007 heart morphogenesis IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0001518 voltage-gated sodium channel complex IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA


Pathways (from Reactome)
Pathway description
Phase 0 - rapid depolarisation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle morphology , abnormal
cardiac ventricle decreased size , abnormal
cardiac ventricle lacks all parts of type trabecular layer of ventricle , abnormal
cardiac ventricle cardiac muscle cell irregular spatial pattern , abnormal
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 ZFA:0000028 heart primordium heart primordium decreased size , abnormal
heart primordium has fewer parts of type cardiac muscle cell , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0000107 eye eye apoptotic , abnormal
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 ZFA:0000109 forebrain forebrain apoptotic , abnormal
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 ZFA:0000114 heart heart hypoplastic , abnormal
heart malformed , abnormal
heart has fewer parts of type cardiac muscle cell , abnormal
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 ZFA:0000115 heart rudiment heart rudiment decreased size , abnormal
heart rudiment has fewer parts of type cardiac muscle cell , abnormal
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 ZFA:0000471 atrium atrium morphology , abnormal
atrium orientation cardiac ventricle , abnormal
atrium decreased size , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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