ENSMUSG00000019461


Mus musculus

Features
Gene ID: ENSMUSG00000019461
  
Biological name :Plscr3
  
Synonyms : Phospholipid scramblase 3 / Plscr3 / Q9JIZ9
  
Possible biological names infered from orthology : Q9NRY6
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 69846376
Gene end: 69852058
  
Corresponding Affymetrix probe sets: 10377612 (MoGene1.0st)   1431081_a_at (Mouse Genome 430 2.0 Array)   1449020_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000019605
Ensembl peptide - ENSMUSP00000104272
Ensembl peptide - ENSMUSP00000104273
Ensembl peptide - ENSMUSP00000123549
NCBI entrez gene - 70310     See in Manteia.
MGI - MGI:1917560
RefSeq - XM_006534158
RefSeq - NM_001168497
RefSeq - NM_023564
RefSeq - XM_006534156
RefSeq - XM_006534157
RefSeq Peptide - NP_001161969
RefSeq Peptide - NP_076053
swissprot - Q5F284
swissprot - Q9JIZ9
swissprot - Q5F283
Ensembl - ENSMUSG00000019461
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plscr3aENSDARG00000093078Danio rerio
 plscr3bENSDARG00000069432Danio rerio
 si:dkey-62k3.6ENSDARG00000091614Danio rerio
 PLSCR3ENSG00000187838Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plscr1 / Q9JJ00 / Phospholipid scramblase 1 / O15162* / PLSCR2* / Q9NRY7* / phospholipid scramblase 2*ENSMUSG0000003236952
Plscr2 / Q9DCW2 / Phospholipid scramblase 2 / Q9NRY7* / O15162* / PLSCR1* / phospholipid scramblase 1*ENSMUSG0000003237245
1700057G04Rik / RIKEN cDNA 1700057G04 gene / PLSCR1* / PLSCR2* / Q9NRY7* / O15162* / phospholipid scramblase 1* / phospholipid scramblase 2*ENSMUSG0000007413940
Plscr5 / phospholipid scramblase family member 5 / A0PG75*ENSMUSG0000009565438
P58196 / Plscr4 / Phospholipid scramblase 4 / Q9NRQ2*ENSMUSG0000003237735


Protein motifs (from Interpro)
Interpro ID Name
 IPR005552  Scramblase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0017121 phospholipid scrambling IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0042632 cholesterol homeostasis IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0017128 phospholipid scramblase activity IBA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000010 abnormal abdominal fat pads "malformed or aberrant size of the encapsulated adipose tissue in the abdomen" [J:65146]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr