ENSMUSG00000032369


Mus musculus

Features
Gene ID: ENSMUSG00000032369
  
Biological name :Plscr1
  
Synonyms : Phospholipid scramblase 1 / Plscr1 / Q9JJ00
  
Possible biological names infered from orthology : O15162 / phospholipid scramblase 2 / PLSCR2 / Q9NRY7
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E3.3
Gene start: 92249750
Gene end: 92272278
  
Corresponding Affymetrix probe sets: 10356082 (MoGene1.0st)   10587792 (MoGene1.0st)   1429527_a_at (Mouse Genome 430 2.0 Array)   1453181_x_at (Mouse Genome 430 2.0 Array)   1457824_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091318
Ensembl peptide - ENSMUSP00000139479
NCBI entrez gene - 22038     See in Manteia.
MGI - MGI:893575
RefSeq - XM_006511052
RefSeq - NM_011636
RefSeq Peptide - NP_035766
swissprot - Q9JJ00
Ensembl - ENSMUSG00000032369
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-71m22.1ENSDARG00000058638Danio rerio
 si:ch211-71m22.3ENSDARG00000079075Danio rerio
 si:ch211-71m22.5ENSDARG00000091266Danio rerio
 si:ch73-170d6.4ENSDARG00000102460Danio rerio
 si:ch73-206p6.1ENSDARG00000077468Danio rerio
 ENSGALG00000006805Gallus gallus
 O15162ENSG00000188313Homo sapiens
 PLSCR2ENSG00000163746Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Plscr2 / Q9DCW2 / Phospholipid scramblase 2 / Q9NRY7* / O15162* / PLSCR1* / phospholipid scramblase 1*ENSMUSG0000003237270
1700057G04Rik / RIKEN cDNA 1700057G04 gene / PLSCR1* / PLSCR2* / Q9NRY7* / O15162* / phospholipid scramblase 1* / phospholipid scramblase 2*ENSMUSG0000007413947
Plscr3 / Q9JIZ9 / Phospholipid scramblase 3 / Q9NRY6*ENSMUSG0000001946147
Plscr5 / phospholipid scramblase family member 5 / A0PG75*ENSMUSG0000009565444
P58196 / Plscr4 / Phospholipid scramblase 4 / Q9NRQ2*ENSMUSG0000003237743


Protein motifs (from Interpro)
Interpro ID Name
 IPR005552  Scramblase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006659 phosphatidylserine biosynthetic process IDA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0006953 acute-phase response IEP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0017121 phospholipid scrambling IDA
 biological_processGO:0030099 myeloid cell differentiation IMP
 biological_processGO:0032091 negative regulation of protein binding IDA
 biological_processGO:0033003 regulation of mast cell activation ISS
 biological_processGO:0035455 response to interferon-alpha IMP
 biological_processGO:0035456 response to interferon-beta ISO
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway ISS
 biological_processGO:0070782 phosphatidylserine exposure on apoptotic cell surface IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEP
 biological_processGO:0071345 cellular response to cytokine stimulus IEP
 biological_processGO:0097193 intrinsic apoptotic signaling pathway IDA
 biological_processGO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding ISS
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0017128 phospholipid scramblase activity ISS
 molecular_functionGO:0019899 enzyme binding ISO
 molecular_functionGO:0042609 CD4 receptor binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl,Tnfrsf1btm1Mwm/Tnfrsf1btm1Mwm
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plscr1tm1Lex/Plscr1tm1Lex,Plscr3tm1Sims/Plscr3tm1Sims
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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