ENSG00000188313


Homo sapiens

Features
Gene ID: ENSG00000188313
  
Biological name :PLSCR1
  
Synonyms : O15162 / phospholipid scramblase 1 / PLSCR1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q24
Gene start: 146515180
Gene end: 146544864
  
Corresponding Affymetrix probe sets: 202430_s_at (Human Genome U133 Plus 2.0 Array)   202446_s_at (Human Genome U133 Plus 2.0 Array)   244315_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418550
Ensembl peptide - ENSP00000420523
Ensembl peptide - ENSP00000420006
Ensembl peptide - ENSP00000419680
Ensembl peptide - ENSP00000419228
Ensembl peptide - ENSP00000418654
Ensembl peptide - ENSP00000345494
Ensembl peptide - ENSP00000411675
Ensembl peptide - ENSP00000417469
Ensembl peptide - ENSP00000417588
Ensembl peptide - ENSP00000417733
Ensembl peptide - ENSP00000417792
Ensembl peptide - ENSP00000418103
NCBI entrez gene - 5359     See in Manteia.
OMIM - 604170
RefSeq - XM_017006629
RefSeq - XM_017006628
RefSeq - XM_011512907
RefSeq - XM_011512906
RefSeq - XM_011512905
RefSeq - NM_021105
RefSeq - XM_005247538
RefSeq - XM_011512904
RefSeq Peptide - NP_066928
swissprot - O15162
swissprot - C9JE06
swissprot - H7C5I5
swissprot - F2Z3F2
swissprot - C9J0H3
swissprot - C9J7K9
swissprot - C9J9P4
Ensembl - ENSG00000188313
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-71m22.1ENSDARG00000058638Danio rerio
 si:ch211-71m22.3ENSDARG00000079075Danio rerio
 si:ch211-71m22.5ENSDARG00000091266Danio rerio
 si:ch73-170d6.4ENSDARG00000102460Danio rerio
 si:ch73-206p6.1ENSDARG00000077468Danio rerio
 ENSGALG00000006805Gallus gallus
 1700057G04RikENSMUSG00000074139Mus musculus
 Plscr1ENSMUSG00000032369Mus musculus
 Plscr2ENSMUSG00000032372Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PLSCR2 / Q9NRY7 / phospholipid scramblase 2ENSG0000016374668
A0PG75 / PLSCR5 / phospholipid scramblase family member 5ENSG0000023121348
PLSCR3 / Q9NRY6 / phospholipid scramblase 3ENSG0000018783847
PLSCR4 / Q9NRQ2 / phospholipid scramblase 4ENSG0000011469847


Protein motifs (from Interpro)
Interpro ID Name
 IPR005552  Scramblase
 IPR025659  Tubby-like, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006659 phosphatidylserine biosynthetic process ISS
 biological_processGO:0006915 apoptotic process IDA
 biological_processGO:0006953 acute-phase response ISS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0017121 phospholipid scrambling IDA
 biological_processGO:0030168 platelet activation NAS
 biological_processGO:0033003 regulation of mast cell activation ISS
 biological_processGO:0035456 response to interferon-beta IMP
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway ISS
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IPI
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0017128 phospholipid scramblase activity IDA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0042609 CD4 receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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