ENSMUSG00000019900


Mus musculus

Features
Gene ID: ENSMUSG00000019900
  
Biological name :Rfx6
  
Synonyms : DNA-binding protein RFX6 / Q8C7R7 / Rfx6
  
Possible biological names infered from orthology : Q8HWS3 / regulatory factor X6
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B3
Gene start: 51677756
Gene end: 51730432
  
Corresponding Affymetrix probe sets: 10363090 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000116057
Ensembl peptide - ENSMUSP00000151599
Ensembl peptide - ENSMUSP00000151430
Ensembl peptide - ENSMUSP00000057384
NCBI entrez gene - 320995     See in Manteia.
MGI - MGI:2445208
RefSeq - NM_001159389
RefSeq - NM_177306
RefSeq Peptide - NP_001152861
RefSeq Peptide - NP_796280
swissprot - Q8C7R7
swissprot - A0A1W2P7F2
swissprot - D5FLC2
Ensembl - ENSMUSG00000019900
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfx6ENSDARG00000041702Danio rerio
 RFX6ENSGALG00000014918Gallus gallus
 RFX6ENSG00000185002Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rfx4 / Q7TNK1 / Transcription factor RFX4 / Q33E94* / regulatory factor X4*ENSMUSG0000002003730
Rfx1 / P48377 / MHC class II regulatory factor RFX1 / P22670* / regulatory factor X1*ENSMUSG0000003170621
Rfx2 / P48379 / DNA-binding protein RFX2 / P48378* / regulatory factor X2*ENSMUSG0000002420620
Rfx3 / P48381 / Transcription factor RFX3 / P48380* / regulatory factor X3*ENSMUSG0000004092919
Rfx8 / D3YU81 / DNA-binding protein RFX8 / Q6ZV50* / RFX family member 8, lacking RFX DNA binding domain*ENSMUSG0000005717316
Rfx7 / regulatory factor X7 / Q2KHR2*ENSMUSG0000003767415
Rfx5 / Q9JL61 / Mus musculus regulatory factor X, 5 (influences HLA class II expression) (Rfx5), transcript variant 2, mRNA. / P48382* / regulatory factor X5*ENSMUSG000000057748


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003309 type B pancreatic cell differentiation IMP
 biological_processGO:0003310 pancreatic A cell differentiation IMP
 biological_processGO:0003311 pancreatic D cell differentiation IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development ISO
 biological_processGO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0050796 regulation of insulin secretion ISO
 biological_processGO:0090104 pancreatic epsilon cell differentiation IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: kkt/kkt+,Pax1un/Pax1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001438 aphagia "inability to eat " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:30404]
Show

Allelic Composition: kkt/kkt+,Pax1un/Pax1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: kkt/kkt+,Pax1un/Pax1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0002606 increased basophil count "higher than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0002607 decreased basophil count "lower than average number of basophils as measured by the percent of the total number of leukocytes" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, MPD:Mouse Phenome Database]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: kkt/kkt+,Pax1un/Pax1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: kkt/kkt+,Pax1un/Pax1+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Psphtm1a(EUCOMM)Hmgu/Psph+
Genetic Background: C57BL/6N-Psphtm1a(EUCOMM)Hmgu/Wtsi

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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