ENSMUSG00000020037


Mus musculus

Features
Gene ID: ENSMUSG00000020037
  
Biological name :Rfx4
  
Synonyms : Q7TNK1 / Rfx4 / Transcription factor RFX4
  
Possible biological names infered from orthology : Q33E94 / regulatory factor X4
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 84756062
Gene end: 84906538
  
Corresponding Affymetrix probe sets: 10365384 (MoGene1.0st)   1432053_at (Mouse Genome 430 2.0 Array)   1436931_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000051107
Ensembl peptide - ENSMUSP00000093035
Ensembl peptide - ENSMUSP00000128690
NCBI entrez gene - 71137     See in Manteia.
MGI - MGI:1918387
RefSeq - XM_006514115
RefSeq - NM_001024918
RefSeq - NM_027689
RefSeq - XM_006514113
RefSeq - XM_006514114
RefSeq Peptide - NP_001020089
RefSeq Peptide - NP_081965
swissprot - Q7TNK1
Ensembl - ENSMUSG00000020037
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfx4ENSDARG00000026395Danio rerio
 RFX4ENSGALG00000012647Gallus gallus
 RFX4ENSG00000111783Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rfx6 / Q8C7R7 / DNA-binding protein RFX6 / Q8HWS3* / regulatory factor X6*ENSMUSG0000001990038
Rfx1 / P48377 / MHC class II regulatory factor RFX1 / P22670* / regulatory factor X1*ENSMUSG0000003170626
Rfx3 / P48381 / Transcription factor RFX3 / P48380* / regulatory factor X3*ENSMUSG0000004092925
Rfx2 / P48379 / DNA-binding protein RFX2 / P48378* / regulatory factor X2*ENSMUSG0000002420624
Rfx8 / D3YU81 / DNA-binding protein RFX8 / Q6ZV50* / RFX family member 8, lacking RFX DNA binding domain*ENSMUSG0000005717318
Rfx7 / regulatory factor X7 / Q2KHR2*ENSMUSG0000003767416
Rfx5 / Q9JL61 / Mus musculus regulatory factor X, 5 (influences HLA class II expression) (Rfx5), transcript variant 2, mRNA. / P48382* / regulatory factor X5*ENSMUSG000000057749


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0021516 dorsal spinal cord development IMP
 biological_processGO:0021537 telencephalon development IMP
 biological_processGO:0021696 cerebellar cortex morphogenesis IMP
 biological_processGO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030901 midbrain development IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0070613 regulation of protein processing IMP
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0000787 abnormal telencephalon morphology "any malformation or absence of the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Pcntm239Asp/Pcnt+,Tg(mI56i-lacZ)1Mekk/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000841 abnormal hindbrain morphology "malformed caudal region of the brain; includes cerebellum, pons and medulla oblongata" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000913 abnormal brain development "malformed or incomplete differentiation of the brain" [MGI:cls, J:49840]
Show

Allelic Composition: Egfl7Gt(1-13)Stmn/Egfl7Gt(1-13)Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000927 small floor plate "reduced size of the floor plate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0002958 aqueductal stenosis "the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0006007 abnormal basal ganglion morphology "malformation or absence of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Egfl7Gt(1-13)Stmn/Egfl7Gt(1-13)Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009717 absent subcommissural organ "absence of the circumventricular organ derived from ependymal cells that is located at the junction of the third ventricle and the cerebral aqueduct and which secretes somatostatin" [MESH:A08.713.810]
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Allelic Composition: Cnga2tm1Gvr/Y
Genetic Background: involves: 129 * C57BL/6

 MP:0011056 abnormal brain ependyma motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011058 abnormal spinal cord motile cilium morphology "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Prkchtm1.2Gasc/Prkchtm1.2Gasc,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Egfl7Gt(1-13)Stmn/Egfl7Gt(1-13)Stmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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