ENSG00000111783


Homo sapiens

Features
Gene ID: ENSG00000111783
  
Biological name :RFX4
  
Synonyms : Q33E94 / regulatory factor X4 / RFX4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q23.3
Gene start: 106582907
Gene end: 106762803
  
Corresponding Affymetrix probe sets: 1552809_at (Human Genome U133 Plus 2.0 Array)   207672_at (Human Genome U133 Plus 2.0 Array)   223673_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449732
Ensembl peptide - ENSP00000448694
Ensembl peptide - ENSP00000473326
Ensembl peptide - ENSP00000376585
Ensembl peptide - ENSP00000350552
Ensembl peptide - ENSP00000229387
Ensembl peptide - ENSP00000444163
Ensembl peptide - ENSP00000447423
Ensembl peptide - ENSP00000447735
NCBI entrez gene - 5992     See in Manteia.
OMIM - 603958
RefSeq - NM_001206691
RefSeq - NM_213594
RefSeq - NM_032491
RefSeq Peptide - NP_115880
RefSeq Peptide - NP_001193620
RefSeq Peptide - NP_998759
swissprot - R4GMS3
swissprot - B4DZB7
swissprot - F8VRD4
swissprot - F8VX50
swissprot - F8VZC4
swissprot - F8W1T9
swissprot - Q33E94
Ensembl - ENSG00000111783
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfx4ENSDARG00000026395Danio rerio
 RFX4ENSGALG00000012647Gallus gallus
 Rfx4ENSMUSG00000020037Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RFX6 / Q8HWS3 / regulatory factor X6ENSG0000018500239
RFX1 / P22670 / regulatory factor X1ENSG0000013200526
RFX3 / P48380 / regulatory factor X3ENSG0000008029825
RFX2 / P48378 / regulatory factor X2ENSG0000008790324
RFX7 / Q2KHR2 / regulatory factor X7ENSG0000018182715
RFX8 / Q6ZV50 / RFX family member 8, lacking RFX DNA binding domainENSG0000019646014
RFX5 / P48382 / regulatory factor X5ENSG0000014339010


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0021516 dorsal spinal cord development IEA
 biological_processGO:0021537 telencephalon development IEA
 biological_processGO:0021696 cerebellar cortex morphogenesis IEA
 biological_processGO:0021914 negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning IBA
 biological_processGO:0030900 forebrain development IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060271 cilium assembly IBA
 biological_processGO:0070613 regulation of protein processing IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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