ENSG00000080298


Homo sapiens

Features
Gene ID: ENSG00000080298
  
Biological name :RFX3
  
Synonyms : P48380 / regulatory factor X3 / RFX3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p24.2
Gene start: 3218297
Gene end: 3526004
  
Corresponding Affymetrix probe sets: 207234_at (Human Genome U133 Plus 2.0 Array)   230403_at (Human Genome U133 Plus 2.0 Array)   238810_at (Human Genome U133 Plus 2.0 Array)   243868_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416189
Ensembl peptide - ENSP00000415594
Ensembl peptide - ENSP00000482598
Ensembl peptide - ENSP00000303847
Ensembl peptide - ENSP00000351574
Ensembl peptide - ENSP00000371414
Ensembl peptide - ENSP00000371434
Ensembl peptide - ENSP00000399352
Ensembl peptide - ENSP00000400026
Ensembl peptide - ENSP00000405664
Ensembl peptide - ENSP00000410988
Ensembl peptide - ENSP00000411756
NCBI entrez gene - 5991     See in Manteia.
OMIM - 601337
RefSeq - XM_017015001
RefSeq - NM_001282116
RefSeq - NM_001282117
RefSeq - NM_002919
RefSeq - NM_134428
RefSeq - XM_006716840
RefSeq - XM_006716843
RefSeq - XM_006716844
RefSeq - XM_006716845
RefSeq - XM_011517998
RefSeq - XM_011517999
RefSeq - XM_011518000
RefSeq - XM_011518001
RefSeq - XM_017015000
RefSeq Peptide - NP_002910
RefSeq Peptide - NP_602304
RefSeq Peptide - NP_001269045
RefSeq Peptide - NP_001269046
swissprot - H0Y790
swissprot - H0Y7W5
swissprot - F6UGA0
swissprot - P48380
swissprot - A9Z1Z2
swissprot - H0Y7Z4
swissprot - F6USP3
swissprot - F6UV76
swissprot - F6XM74
Ensembl - ENSG00000080298
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfx3ENSDARG00000014550Danio rerio
 RFX3ENSGALG00000010179Gallus gallus
 Rfx3ENSMUSG00000040929Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RFX2 / P48378 / regulatory factor X2ENSG0000008790364
RFX1 / P22670 / regulatory factor X1ENSG0000013200558
RFX4 / Q33E94 / regulatory factor X4ENSG0000011178325
RFX6 / Q8HWS3 / regulatory factor X6ENSG0000018500224
RFX7 / Q2KHR2 / regulatory factor X7ENSG0000018182714
RFX8 / Q6ZV50 / RFX family member 8, lacking RFX DNA binding domainENSG0000019646012
RFX5 / P48382 / regulatory factor X5ENSG000001433909


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR007668  RFX1 transcription activation region
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003309 type B pancreatic cell differentiation IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031018 endocrine pancreas development ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048469 cell maturation ISS
 biological_processGO:0050796 regulation of insulin secretion ISS
 biological_processGO:0060271 cilium assembly ISS
 biological_processGO:0060285 cilium-dependent cell motility ISS
 biological_processGO:0060287 epithelial cilium movement involved in determination of left/right asymmetry ISS
 biological_processGO:0072560 type B pancreatic cell maturation IEA
 biological_processGO:2000078 positive regulation of type B pancreatic cell development ISS
 cellular_componentGO:0000790 nuclear chromatin IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005667 transcription factor complex IC
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003700 DNA-binding transcription factor activity NAS
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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