ENSMUSG00000005774


Mus musculus

Features
Gene ID: ENSMUSG00000005774
  
Biological name :Rfx5
  
Synonyms : Mus musculus regulatory factor X, 5 (influences HLA class II expression) (Rfx5), transcript variant 2, mRNA. / Q9JL61 / Rfx5
  
Possible biological names infered from orthology : P48382 / regulatory factor X5
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 94954075
Gene end: 94961561
  
Corresponding Affymetrix probe sets: 10494122 (MoGene1.0st)   1423103_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118014
Ensembl peptide - ENSMUSP00000117999
Ensembl peptide - ENSMUSP00000118099
Ensembl peptide - ENSMUSP00000121157
Ensembl peptide - ENSMUSP00000119704
Ensembl peptide - ENSMUSP00000118586
Ensembl peptide - ENSMUSP00000029772
Ensembl peptide - ENSMUSP00000102874
Ensembl peptide - ENSMUSP00000102875
Ensembl peptide - ENSMUSP00000102876
Ensembl peptide - ENSMUSP00000102881
Ensembl peptide - ENSMUSP00000114908
Ensembl peptide - ENSMUSP00000116675
Ensembl peptide - ENSMUSP00000117963
NCBI entrez gene - 53970     See in Manteia.
MGI - MGI:1858421
RefSeq - XM_017319652
RefSeq - NM_001355705
RefSeq - NM_001355706
RefSeq - NM_001355707
RefSeq - NM_017395
RefSeq - XM_006501694
RefSeq - XM_006501695
RefSeq - XM_006501697
RefSeq - XM_006501698
RefSeq - XM_006501699
RefSeq - XM_006501700
RefSeq - XM_011240164
RefSeq - XM_017319651
RefSeq Peptide - NP_059091
RefSeq Peptide - NP_001342634
RefSeq Peptide - NP_001342635
RefSeq Peptide - NP_001342636
swissprot - D3YVW1
swissprot - D6RDE5
swissprot - Q9JL61
swissprot - D3YTK4
swissprot - Q6DI69
swissprot - D3Z0D4
swissprot - D3YZK7
swissprot - K4DI79
Ensembl - ENSMUSG00000005774
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfx5ENSDARG00000063258Danio rerio
 RFX5ENSGALG00000000836Gallus gallus
 RFX5ENSG00000143390Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rfx7 / regulatory factor X7 / Q2KHR2*ENSMUSG0000003767430
Rfx1 / P48377 / MHC class II regulatory factor RFX1 / P22670* / regulatory factor X1*ENSMUSG0000003170612
Rfx6 / Q8C7R7 / DNA-binding protein RFX6 / Q8HWS3* / regulatory factor X6*ENSMUSG0000001990011
Rfx2 / P48379 / DNA-binding protein RFX2 / P48378* / regulatory factor X2*ENSMUSG0000002420610
Rfx4 / Q7TNK1 / Transcription factor RFX4 / Q33E94* / regulatory factor X4*ENSMUSG0000002003710
Rfx3 / P48381 / Transcription factor RFX3 / P48380* / regulatory factor X3*ENSMUSG0000004092910
Rfx8 / D3YU81 / DNA-binding protein RFX8 / Q6ZV50* / RFX family member 8, lacking RFX DNA binding domain*ENSMUSG000000571737


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR029298  RFX5, C-terminal
 IPR033486  DNA-binding protein RFX5
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IBA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002453 abnormal B lymphocyte antigen presentation "impairment in the ability of B lymphocyte to process and/or present antigen " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005040 abnormal MHC II cell surface expression on macrophages "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31326]
Show

Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Rfx5tm1.1Ifo/Rfx5tm1.1Ifo
Genetic Background: involves: 129 * C57BL/6

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: H2-Oatm1Dma/H2-Oatm1Dma
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005461 abnormal dendritic cell morphology/development "anomalous structure or atypical formation of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rfx5tm1.1Ifo/Rfx5tm1.1Ifo
Genetic Background: involves: 129 * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rfx5tm1.1Ifo/Rfx5tm1.1Ifo
Genetic Background: involves: 129 * C57BL/6

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rfx5tm1.1Ifo/Rfx5tm1.1Ifo
Genetic Background: involves: 129 * C57BL/6

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rfx5tm1.1Ifo/Rfx5tm1.1Ifo
Genetic Background: involves: 129 * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rfx5tm1.1Ifo/Rfx5tm1.1Ifo
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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