ENSMUSG00000024206


Mus musculus

Features
Gene ID: ENSMUSG00000024206
  
Biological name :Rfx2
  
Synonyms : DNA-binding protein RFX2 / P48379 / Rfx2
  
Possible biological names infered from orthology : P48378 / regulatory factor X2
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 56775897
Gene end: 56831008
  
Corresponding Affymetrix probe sets: 10452151 (MoGene1.0st)   1417332_at (Mouse Genome 430 2.0 Array)   1433416_at (Mouse Genome 430 2.0 Array)   1442578_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002444
Ensembl peptide - ENSMUSP00000084010
NCBI entrez gene - 19725     See in Manteia.
MGI - MGI:106583
RefSeq - NM_009056
RefSeq - NM_027787
RefSeq Peptide - NP_033082
RefSeq Peptide - NP_082063
swissprot - P48379
Ensembl - ENSMUSG00000024206
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rfx2ENSDARG00000013575Danio rerio
 RFX2ENSGALG00000001773Gallus gallus
 RFX2ENSG00000087903Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rfx3 / P48381 / Transcription factor RFX3 / P48380* / regulatory factor X3*ENSMUSG0000004092965
Rfx1 / P48377 / MHC class II regulatory factor RFX1 / P22670* / regulatory factor X1*ENSMUSG0000003170656
Rfx4 / Q7TNK1 / Transcription factor RFX4 / Q33E94* / regulatory factor X4*ENSMUSG0000002003725
Rfx6 / Q8C7R7 / DNA-binding protein RFX6 / Q8HWS3* / regulatory factor X6*ENSMUSG0000001990025
Rfx8 / D3YU81 / DNA-binding protein RFX8 / Q6ZV50* / RFX family member 8, lacking RFX DNA binding domain*ENSMUSG0000005717319
Rfx7 / regulatory factor X7 / Q2KHR2*ENSMUSG0000003767416
Rfx5 / Q9JL61 / Mus musculus regulatory factor X, 5 (influences HLA class II expression) (Rfx5), transcript variant 2, mRNA. / P48382* / regulatory factor X5*ENSMUSG000000057749


Protein motifs (from Interpro)
Interpro ID Name
 IPR003150  DNA-binding RFX-type winged-helix domain
 IPR007668  RFX1 transcription activation region
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm ISS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IMP
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001932 abnormal spermiogenesis "failure of sperm cells to form or differentiate" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0013598 Leydig cell hypertrophy "increased size of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH)" [MGI:Anna]
Show

Allelic Composition: Bmi1tm1.1Lees/Bmi1tm1.1Lees
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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