ENSMUSG00000020155


Mus musculus

Features
Gene ID: ENSMUSG00000020155
  
Biological name :Kcnmb1
  
Synonyms : Kcnmb1 / potassium calcium-activated channel subfamily M regulatory beta subunit 1
  
Possible biological names infered from orthology : Q16558
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A4
Gene start: 33963013
Gene end: 33973641
  
Corresponding Affymetrix probe sets: 10375137 (MoGene1.0st)   1421400_at (Mouse Genome 430 2.0 Array)   1421401_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020362
NCBI entrez gene - 16533     See in Manteia.
MGI - MGI:1334203
RefSeq - NM_031169
RefSeq - XM_006514541
RefSeq Peptide - NP_112446
swissprot - Q5SQK1
Ensembl - ENSMUSG00000020155
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnmb2ENSDARG00000006568Danio rerio
 si:ch211-247n2.1ENSDARG00000001712Danio rerio
 KCNMB1ENSGALG00000002118Gallus gallus
 KCNMB1ENSG00000145936Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnmb2 / Q9CZM9 / Calcium-activated potassium channel subunit beta-2 / Q9Y691* / AC117457.1* / potassium calcium-activated channel subfamily M regulatory beta subunit 2*ENSMUSG0000003761043
Kcnmb3 / potassium calcium-activated channel subfamily M regulatory beta subunit 3 / Q9NPA1*ENSMUSG0000009109129
Kcnmb4 / Q9JIN6 / Calcium-activated potassium channel subunit beta-4 / Q86W47* / potassium calcium-activated channel subfamily M regulatory beta subunit 4*ENSMUSG0000005493421


Protein motifs (from Interpro)
Interpro ID Name
 IPR003930  Potassium channel, calcium-activated, BK, beta subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IEA
 biological_processGO:1903413 cellular response to bile acid IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015269 calcium-activated potassium channel activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity IEA


Pathways (from Reactome)
Pathway description
Ca2+ activated K+ channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000250 abnormal vasoconstriction "anomalous narrowing of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002847 abnormal glomerular filtration rate "deviation from the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dnmt3btm1Enl/Dnmt3btm7Enl
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

Allelic Composition: Kcnmb1tm1Ltor/Kcnmb1tm1Ltor
Genetic Background: Not Specified

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnmb1tm1Rwa/Kcnmb1tm1Rwa
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020155 Kcnmb1 / potassium calcium-activated channel subfamily M regulatory beta subunit 1 / Q16558*  / complex
 ENSMUSG00000054934 Kcnmb4 / Q9JIN6 / Calcium-activated potassium channel subunit beta-4 / Q86W47* / potassium calcium-activated channel subfamily M regulatory beta subunit 4*  / complex
 ENSMUSG00000037610 Kcnmb2 / Q9CZM9 / Calcium-activated potassium channel subunit beta-2 / Q9Y691* / AC117457.1* / potassium calcium-activated channel subfamily M regulatory beta subunit 2*  / complex
 ENSMUSG00000091091 Kcnmb3 / potassium calcium-activated channel subfamily M regulatory beta subunit 3 / Q9NPA1*  / complex






 

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