ENSG00000145936


Homo sapiens

Features
Gene ID: ENSG00000145936
  
Biological name :KCNMB1
  
Synonyms : KCNMB1 / potassium calcium-activated channel subfamily M regulatory beta subunit 1 / Q16558
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.1
Gene start: 170374671
Gene end: 170389677
  
Corresponding Affymetrix probe sets: 1554710_at (Human Genome U133 Plus 2.0 Array)   209948_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427940
Ensembl peptide - ENSP00000274629
NCBI entrez gene - 3779     See in Manteia.
OMIM - 603951
RefSeq - NM_004137
RefSeq Peptide - NP_004128
swissprot - Q16558
Ensembl - ENSG00000145936
  
Related genetic diseases (OMIM): 608622 - {Hypertension, diastolic, resistance to}, 608622
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnmb2ENSDARG00000006568Danio rerio
 si:ch211-247n2.1ENSDARG00000001712Danio rerio
 KCNMB1ENSGALG00000002118Gallus gallus
 Kcnmb1ENSMUSG00000020155Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AC117457.1ENSG0000027516343
KCNMB2 / Q9Y691 / potassium calcium-activated channel subfamily M regulatory beta subunit 2ENSG0000019758443
KCNMB3 / Q9NPA1 / potassium calcium-activated channel subfamily M regulatory beta subunit 3ENSG0000017112131
KCNMB4 / Q86W47 / potassium calcium-activated channel subfamily M regulatory beta subunit 4ENSG0000013564321


Protein motifs (from Interpro)
Interpro ID Name
 IPR003930  Potassium channel, calcium-activated, BK, beta subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005513 detection of calcium ion IBA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport TAS
 biological_processGO:0007268 chemical synaptic transmission TAS
 biological_processGO:0007568 aging IEA
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0071361 cellular response to ethanol IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071805 potassium ion transmembrane transport IBA
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1901381 positive regulation of potassium ion transmembrane transport IEA
 biological_processGO:1903413 cellular response to bile acid IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0015269 calcium-activated potassium channel activity IBA
 molecular_functionGO:0015459 potassium channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Ca2+ activated K+ channels
cGMP effects


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000138669 PRKG2 / Q13237 / protein kinase, cGMP-dependent, type II  / reaction
 ENSG00000135643 KCNMB4 / Q86W47 / potassium calcium-activated channel subfamily M regulatory beta subunit 4  / complex
 ENSG00000156113 KCNMA1 / Q12791 / potassium calcium-activated channel subfamily M alpha 1  / complex
 ENSG00000171121 KCNMB3 / Q9NPA1 / potassium calcium-activated channel subfamily M regulatory beta subunit 3  / complex
 ENSG00000197584 KCNMB2 / Q9Y691 / potassium calcium-activated channel subfamily M regulatory beta subunit 2  / complex
 ENSG00000145936 KCNMB1 / Q16558 / potassium calcium-activated channel subfamily M regulatory beta subunit 1  / complex
 ENSG00000185532 PRKG1 / Q13976 / protein kinase, cGMP-dependent, type I  / reaction






 

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