ENSMUSG00000020277


Mus musculus

Features
Gene ID: ENSMUSG00000020277
  
Biological name :Pfkl
  
Synonyms : ATP-dependent 6-phosphofructokinase, liver type / P12382 / Pfkl
  
Possible biological names infered from orthology : P17858 / phosphofructokinase, liver type
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 77986947
Gene end: 78010083
  
Corresponding Affymetrix probe sets: 10370376 (MoGene1.0st)   1439148_a_at (Mouse Genome 430 2.0 Array)   1450269_a_at (Mouse Genome 430 2.0 Array)   1453541_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020522
Ensembl peptide - ENSMUSP00000151752
Ensembl peptide - ENSMUSP00000151375
NCBI entrez gene - 18641     See in Manteia.
MGI - MGI:97547
RefSeq - NM_008826
RefSeq - XM_017313846
RefSeq Peptide - NP_032852
swissprot - A0A1W2P7T1
swissprot - P12382
swissprot - A0A1W2P6Q4
Ensembl - ENSMUSG00000020277
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfklaENSDARG00000060504Danio rerio
 pfklbENSDARG00000099755Danio rerio
 PFKLENSGALG00000006543Gallus gallus
 PFKLENSG00000141959Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pfkm / P47857 / Mus musculus phosphofructokinase, muscle (Pfkm), transcript variant 4, mRNA. / P08237* / phosphofructokinase, muscle*ENSMUSG0000003306568
Pfkp / Q9WUA3 / ATP-dependent 6-phosphofructokinase, platelet type / Q01813* / phosphofructokinase, platelet*ENSMUSG0000002119663


Protein motifs (from Interpro)
Interpro ID Name
 IPR000023  Phosphofructokinase domain
 IPR009161  ATP-dependent 6-phosphofructokinase, eukaryotic-type
 IPR015912  Phosphofructokinase, conserved site
 IPR022953  ATP-dependent 6-phosphofructokinase
 IPR035966  Phosphofructokinase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0006002 fructose 6-phosphate metabolic process IEA
 biological_processGO:0006096 glycolytic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030388 fructose 1,6-bisphosphate metabolic process IEA
 biological_processGO:0046676 negative regulation of insulin secretion IDA
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0061615 glycolytic process through fructose-6-phosphate IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005945 6-phosphofructokinase complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003872 6-phosphofructokinase activity IEA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048029 monosaccharide binding IEA
 molecular_functionGO:0070061 fructose binding IEA
 molecular_functionGO:0070095 fructose-6-phosphate binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020277 Pfkl / P12382 / ATP-dependent 6-phosphofructokinase, liver type / P17858* / phosphofructokinase, liver type*  / complex
 ENSMUSG00000021196 Pfkp / Q9WUA3 / ATP-dependent 6-phosphofructokinase, platelet type / Q01813* / phosphofructokinase, platelet*  / complex
 ENSMUSG00000033065 Pfkm / P47857 / Mus musculus phosphofructokinase, muscle (Pfkm), transcript variant 4, mRNA. / P08237* / phosphofructokinase, muscle*  / complex






 

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