ENSMUSG00000033065


Mus musculus

Features
Gene ID: ENSMUSG00000033065
  
Biological name :Pfkm
  
Synonyms : Mus musculus phosphofructokinase, muscle (Pfkm), transcript variant 4, mRNA. / P47857 / Pfkm
  
Possible biological names infered from orthology : P08237 / phosphofructokinase, muscle
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: F1
Gene start: 98092589
Gene end: 98132451
  
Corresponding Affymetrix probe sets: 10426557 (MoGene1.0st)   1416780_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000155453
Ensembl peptide - ENSMUSP00000132803
Ensembl peptide - ENSMUSP00000154896
Ensembl peptide - ENSMUSP00000059801
Ensembl peptide - ENSMUSP00000155809
NCBI entrez gene - 18642     See in Manteia.
MGI - MGI:97548
RefSeq - XM_006520602
RefSeq - NM_001163487
RefSeq - NM_001163488
RefSeq - NM_001357688
RefSeq - NM_021514
RefSeq - XM_006520601
RefSeq Peptide - NP_001344617
RefSeq Peptide - NP_067489
RefSeq Peptide - NP_001156959
RefSeq Peptide - NP_001156960
swissprot - P47857
Ensembl - ENSMUSG00000033065
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pfkmaENSDARG00000014179Danio rerio
 pfkmbENSDARG00000060797Danio rerio
 PFKMENSG00000152556Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pfkl / P12382 / ATP-dependent 6-phosphofructokinase, liver type / P17858* / phosphofructokinase, liver type*ENSMUSG0000002027768
Pfkp / Q9WUA3 / ATP-dependent 6-phosphofructokinase, platelet type / Q01813* / phosphofructokinase, platelet*ENSMUSG0000002119666


Protein motifs (from Interpro)
Interpro ID Name
 IPR000023  Phosphofructokinase domain
 IPR009161  ATP-dependent 6-phosphofructokinase, eukaryotic-type
 IPR015912  Phosphofructokinase, conserved site
 IPR022953  ATP-dependent 6-phosphofructokinase
 IPR035966  Phosphofructokinase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005980 glycogen catabolic process IMP
 biological_processGO:0006002 fructose 6-phosphate metabolic process ISO
 biological_processGO:0006096 glycolytic process ISO
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032024 positive regulation of insulin secretion IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0046716 muscle cell cellular homeostasis ISO
 biological_processGO:0046835 carbohydrate phosphorylation IEA
 biological_processGO:0051259 protein complex oligomerization ISO
 biological_processGO:0061615 glycolytic process through fructose-6-phosphate ISO
 biological_processGO:0061621 canonical glycolysis IMP
 biological_processGO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0005945 6-phosphofructokinase complex ISO
 cellular_componentGO:0016324 apical plasma membrane ISO
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0097228 sperm principal piece IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003872 6-phosphofructokinase activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0008443 phosphofructokinase activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019900 kinase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070061 fructose binding ISO


Pathways (from Reactome)
Pathway description
Glycolysis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd247tm1Mal/Cd247tm1Mal
Genetic Background: either: C57BL/6-Cd247tm1Mal or (involves: BALB/c * C57BL/6)

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Gfra2tm1Jmi/Gfra2tm1Jmi
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009412 skeletal muscle fiber degeneration "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0009414 skeletal muscle fiber necrosis "pathological cell death in the skeletal muscle fibers, usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0010401 increased skeletal muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0011084 partial lethality at weaning "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0012106 impaired exercise endurance "impaired performance during controlled physical activity" [MGI:smb]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0013404 decreased circulating lactate level "reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0014071 increased cardiac muscle glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in heart muscle" [MGI:Anna]
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Allelic Composition: Pfkmtm1Fbos/Pfkmtm1Fbos
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000033065 Pfkm / P47857 / Mus musculus phosphofructokinase, muscle (Pfkm), transcript variant 4, mRNA. / P08237* / phosphofructokinase, muscle*  / complex
 ENSMUSG00000020277 Pfkl / P12382 / ATP-dependent 6-phosphofructokinase, liver type / P17858* / phosphofructokinase, liver type*  / complex






 

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