ENSMUSG00000020581


Mus musculus

Features
Gene ID: ENSMUSG00000020581
  
Biological name :Agr2
  
Synonyms : Agr2 / Anterior gradient / O88312
  
Possible biological names infered from orthology : anterior gradient 2, protein disulphide isomerase family member / O95994
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A3
Gene start: 35992907
Gene end: 36004087
  
Corresponding Affymetrix probe sets: 10395365 (MoGene1.0st)   1419268_at (Mouse Genome 430 2.0 Array)   1455802_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020898
NCBI entrez gene - 23795     See in Manteia.
MGI - MGI:1344405
RefSeq - NM_011783
RefSeq Peptide - NP_035913
swissprot - O88312
Ensembl - ENSMUSG00000020581
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agr2ENSDARG00000070480Danio rerio
 AGR2ENSGALG00000010825Gallus gallus
 AGR2ENSG00000106541Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agr3 / Q8R3W7 / Anterior gradient protein 3 / Q8TD06* / anterior gradient 3, protein disulphide isomerase family member*ENSMUSG0000003623158
Q9CQU0 / Txndc12 / thioredoxin domain containing 12 (endoplasmic reticulum) / O95881* / thioredoxin domain containing 12*ENSMUSG0000002856732


Protein motifs (from Interpro)
Interpro ID Name
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048639 positive regulation of developmental growth IMP
 biological_processGO:0060480 lung goblet cell differentiation IDA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070254 mucus secretion IMP
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane IEA
 biological_processGO:1903896 positive regulation of IRE1-mediated unfolded protein response IEA
 biological_processGO:1903899 positive regulation of PERK-mediated unfolded protein response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 molecular_functionGO:0002162 dystroglycan binding IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000324 increased mast cell number "greater than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Brca1tm2.1Thl/Brca1tm2.1Thl
Genetic Background: involves: 129

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
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Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0000479 abnormal intestinal cell "anomalous structure or development of the cells comprising the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000489 abnormal large intestine morphology "structural or developmental anomalies of the intestinum crassum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0000493 rectal prolapse "downward movement and external appearance of the rectum through the anus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agr2tm1Lex/Agr2tm1Lex,Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6

 MP:0002389 abnormal Peyer s patch follicle morphology "anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003270 intestinal obstruction "any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0004139 abnormal parietal cell morphology "malformation of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0004140 abnormal chief cell morphology "malformation of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Elf5tm1Sin/Elf5tm1Sin,Tg(MMTV-cre)4Mam/0
Genetic Background: involves: C57BL/6 * FVB

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

 MP:0008907 decreased total fat pad weight "less than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0009482 ileum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ileum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0010799 stomach mucosa hyperplasia "overdevelopment or increased size, usually due to an increase in the number of cells, of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0010803 abnormal stomach enteroendocrine cell morphology "any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agr2tm1.1Lex/Agr2tm1.1Lex
Genetic Background: involves: 129S5/SvEvBrd * BALB/cJ * C57BL/6

 MP:0013485 increased Paneth cell number "greater than normal numbers of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:Anna]
Show

Allelic Composition: Agr2tm1.1Lpkn/Agr2tm1.1Lpkn,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6

Allelic Composition: Agr2tm1.2Lpkn/Agr2tm1.2Lpkn
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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