ENSMUSG00000020594


Mus musculus

Features
Gene ID: ENSMUSG00000020594
  
Biological name :Pum2
  
Synonyms : Pum2 / pumilio RNA-binding family member 2 / Q80U58
  
Possible biological names infered from orthology : Q8TB72
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 8674134
Gene end: 8752581
  
Corresponding Affymetrix probe sets: 10394448 (MoGene1.0st)   1418015_at (Mouse Genome 430 2.0 Array)   1418016_at (Mouse Genome 430 2.0 Array)   1418017_at (Mouse Genome 430 2.0 Array)   1441448_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131914
Ensembl peptide - ENSMUSP00000131074
Ensembl peptide - ENSMUSP00000132122
Ensembl peptide - ENSMUSP00000137020
Ensembl peptide - ENSMUSP00000132170
Ensembl peptide - ENSMUSP00000020915
Ensembl peptide - ENSMUSP00000106751
Ensembl peptide - ENSMUSP00000106752
Ensembl peptide - ENSMUSP00000126616
Ensembl peptide - ENSMUSP00000126876
Ensembl peptide - ENSMUSP00000127786
Ensembl peptide - ENSMUSP00000128292
Ensembl peptide - ENSMUSP00000129243
Ensembl peptide - ENSMUSP00000130320
NCBI entrez gene - 80913     See in Manteia.
MGI - MGI:1931751
RefSeq - XM_017315259
RefSeq - NM_001310519
RefSeq - NM_030723
RefSeq - XM_006515277
RefSeq - XM_006515278
RefSeq - XM_006515279
RefSeq - XM_006515280
RefSeq - XM_006515282
RefSeq - XM_006515283
RefSeq - XM_006515284
RefSeq - XM_006515285
RefSeq - XM_017315254
RefSeq - XM_017315255
RefSeq - XM_017315256
RefSeq - XM_017315257
RefSeq - XM_017315258
RefSeq - NM_001160219
RefSeq - NM_001160220
RefSeq - NM_001160221
RefSeq - NM_001160222
RefSeq Peptide - NP_001297448
RefSeq Peptide - NP_109648
RefSeq Peptide - NP_001153691
RefSeq Peptide - NP_001153692
RefSeq Peptide - NP_001153693
RefSeq Peptide - NP_001153694
swissprot - Q3UR91
swissprot - Q80U58
swissprot - E9PW51
swissprot - Q3TQ29
swissprot - E9Q4Q6
swissprot - F6YD01
swissprot - F7A034
swissprot - E9Q0P1
swissprot - E9Q765
Ensembl - ENSMUSG00000020594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pum2ENSDARG00000061040Danio rerio
 PUM2ENSGALG00000016481Gallus gallus
 PUM2ENSG00000055917Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pum1 / Q80U78 / pumilio RNA-binding family member 1 / Q14671*ENSMUSG0000002858077


Protein motifs (from Interpro)
Interpro ID Name
 IPR001313  Pumilio RNA-binding repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR033133  Pumilio homology domain
 IPR033712  Pumilio, RNA binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0010608 posttranscriptional regulation of gene expression IEA
 biological_processGO:0034063 stress granule assembly IDA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IEA
 biological_processGO:0043488 regulation of mRNA stability IEA
 biological_processGO:0051983 regulation of chromosome segregation IEA
 biological_processGO:1900246 positive regulation of RIG-I signaling pathway IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0010494 cytoplasmic stress granule IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003730 mRNA 3"-UTR binding IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035198 miRNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001154 seminiferous tubule degeneration "a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: KitW-39J/KitW-43J
Genetic Background: involves: C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: KitW-39J/KitW-43J
Genetic Background: involves: C57BL/6J

Allelic Composition: Dazltm1Hjc/Dazl+,Pum2Gt(XE772)Byg/Pum2Gt(XE772)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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