ENSMUSG00000028580


Mus musculus

Features
Gene ID: ENSMUSG00000028580
  
Biological name :Pum1
  
Synonyms : Pum1 / pumilio RNA-binding family member 1 / Q80U78
  
Possible biological names infered from orthology : Q14671
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 130663321
Gene end: 130781564
  
Corresponding Affymetrix probe sets: 10508619 (MoGene1.0st)   1423117_at (Mouse Genome 430 2.0 Array)   1456054_a_at (Mouse Genome 430 2.0 Array)   1460325_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000101613
Ensembl peptide - ENSMUSP00000101612
Ensembl peptide - ENSMUSP00000114629
Ensembl peptide - ENSMUSP00000030315
Ensembl peptide - ENSMUSP00000095474
Ensembl peptide - ENSMUSP00000095476
NCBI entrez gene - 80912     See in Manteia.
MGI - MGI:1931749
RefSeq - XM_017320466
RefSeq - XM_006539311
RefSeq - XM_006539312
RefSeq - XM_006539314
RefSeq - XM_011250358
RefSeq - XM_011250359
RefSeq - XM_011250360
RefSeq - XM_017320459
RefSeq - XM_017320460
RefSeq - XM_017320461
RefSeq - XM_017320462
RefSeq - XM_017320463
RefSeq - XM_017320464
RefSeq - NM_001159603
RefSeq - NM_001159604
RefSeq - NM_001159605
RefSeq - NM_001159606
RefSeq - NM_001356565
RefSeq - NM_001356566
RefSeq - NM_030722
RefSeq - XM_006539291
RefSeq - XM_006539292
RefSeq - XM_006539293
RefSeq - XM_006539294
RefSeq - XM_006539295
RefSeq - XM_006539296
RefSeq - XM_006539297
RefSeq - XM_006539298
RefSeq - XM_006539299
RefSeq - XM_006539300
RefSeq - XM_006539301
RefSeq - XM_006539302
RefSeq - XM_006539303
RefSeq - XM_006539304
RefSeq - XM_006539305
RefSeq - XM_006539306
RefSeq - XM_006539308
RefSeq - XM_006539309
RefSeq - XM_006539310
RefSeq Peptide - NP_001343494
RefSeq Peptide - NP_001153075
RefSeq Peptide - NP_001153076
RefSeq Peptide - NP_001153077
RefSeq Peptide - NP_001153078
RefSeq Peptide - NP_001343495
RefSeq Peptide - NP_109647
swissprot - Q80U78
swissprot - Q3TQ21
swissprot - Q3TTW5
swissprot - E9Q6M7
swissprot - A8WHM8
Ensembl - ENSMUSG00000028580
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pum1ENSDARG00000099256Danio rerio
 PUM1ENSGALG00000042598Gallus gallus
 PUM1ENSG00000134644Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pum2 / Q80U58 / pumilio RNA-binding family member 2 / Q8TB72*ENSMUSG0000002059469


Protein motifs (from Interpro)
Interpro ID Name
 IPR001313  Pumilio RNA-binding repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR033133  Pumilio homology domain
 IPR033712  Pumilio, RNA binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0010608 posttranscriptional regulation of gene expression ISO
 biological_processGO:0016441 posttranscriptional gene silencing IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA ISS
 biological_processGO:0043488 regulation of mRNA stability ISO
 biological_processGO:0048863 stem cell differentiation IMP
 biological_processGO:0051726 regulation of cell cycle ISS
 biological_processGO:0051983 regulation of chromosome segregation ISO
 biological_processGO:0061157 mRNA destabilization IDA
 biological_processGO:1900246 positive regulation of RIG-I signaling pathway ISO
 biological_processGO:2000637 positive regulation of gene silencing by miRNA ISO
 cellular_componentGO:0000932 P-body ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0010494 cytoplasmic stress granule ISO
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003730 mRNA 3"-UTR binding ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0035198 miRNA binding ISO


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
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Allelic Composition: Pum1tm1.2Hfl/Pum1+
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Pum1tm1.2Hfl/Pum1tm1.2Hfl,Trp53tm1Tyj/Trp53tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6 * FVB

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
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Allelic Composition: Pum1tm1.2Hfl/Pum1+
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Pum1tm1.2Hfl/Pum1+
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Pum1tm1.2Hfl/Pum1+
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pum1tm1.2Hfl/Pum1+
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Pum1tm1.2Hfl/Pum1tm1.2Hfl
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pum1tm1.2Hfl/Pum1tm1.2Hfl
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebf1tm1.1Rug/Ebf1tm1.1Rug,Ighg1tm1(cre)Cgn/Ighg1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Pum1tm1.2Hfl/Pum1+
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Pum1tm1.2Hfl/Pum1tm1.2Hfl
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Rps27lGt(IST11658B7)Tigm/Rps27lGt(IST11658B7)Tigm
Genetic Background: involves: 129S2/SvPas * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000050708 Ftl1 / FTL* / P02792* / ferritin light chain*  / complex
 ENSMUSG00000028082 Q91X43 / Sh3d19 / SH3 domain-containing protein 19 / Q5HYK7* / SH3 domain containing 19*  / complex
 ENSMUSG00000024661 Fth1 / P09528 / Ferritin heavy chain Ferritin heavy chain, N-terminally processed / P02794* / ferritin heavy chain 1*  / complex
 ENSMUSG00000006169 Clint1 / Mus musculus clathrin interactor 1 (Clint1), transcript variant 2, mRNA. / Q14677* / clathrin interactor 1*  / complex






 

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