ENSMUSG00000024661


Mus musculus

Features
Gene ID: ENSMUSG00000024661
  
Biological name :Fth1
  
Synonyms : Ferritin heavy chain Ferritin heavy chain, N-terminally processed / Fth1 / P09528
  
Possible biological names infered from orthology : ferritin heavy chain 1 / P02794
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: A
Gene start: 9982703
Gene end: 9985092
  
Corresponding Affymetrix probe sets: 10461402 (MoGene1.0st)   1427021_s_at (Mouse Genome 430 2.0 Array)   1448771_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025563
NCBI entrez gene - 14319     See in Manteia.
MGI - MGI:95588
RefSeq - NM_010239
RefSeq Peptide - NP_034369
swissprot - P09528
Ensembl - ENSMUSG00000024661
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fth1aENSDARG00000015551Danio rerio
 fth1bENSDARG00000007975Danio rerio
 FTH1ENSGALG00000007220Gallus gallus
 FTH1ENSG00000167996Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ftmt / Q9D5H4 / Ferritin, mitochondrial / Q8N4E7*ENSMUSG0000002451078
Fthl17b / FTHL17* / Q9BXU8* / ferritin heavy chain like 17*ENSMUSG0000007820855
Fthl17c / Mus musculus ferritin, heavy polypeptide-like 17, pseudo 1 (Fthl17-ps1), mRNA. / FTHL17* / Q9BXU8* / ferritin heavy chain like 17*ENSMUSG0000006068555
Fthl17f / FTHL17* / Q9BXU8* / ferritin heavy chain like 17*ENSMUSG0000007224952
Fthl17d / FTHL17* / Q9BXU8* / ferritin heavy chain like 17*ENSMUSG0000007820652
Fthl17 / Q99MX2 / Ferritin heavy polypeptide-like 17 / Q9BXU8* / ferritin heavy chain like 17*ENSMUSG0000007181552
Ftl1-ps1 / FTL* / P02792* / ferritin light chain*ENSMUSG0000006238251
Ftl1 / FTL* / P02792* / ferritin light chain*ENSMUSG0000005070851
Fthl17a / FTHL17* / Q9BXU8* / ferritin heavy chain like 17*ENSMUSG0000003549146


Protein motifs (from Interpro)
Interpro ID Name
 IPR001519  Ferritin
 IPR008331  Ferritin/DPS protein domain
 IPR009040  Ferritin-like diiron domain
 IPR009078  Ferritin-like superfamily
 IPR012347  Ferritin-like
 IPR014034  Ferritin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006826 iron ion transport IEA
 biological_processGO:0006879 cellular iron ion homeostasis IEA
 biological_processGO:0006880 intracellular sequestering of iron ion IEA
 biological_processGO:0006955 immune response ISS
 biological_processGO:0008285 negative regulation of cell proliferation ISS
 biological_processGO:0048147 negative regulation of fibroblast proliferation IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0097286 iron ion import IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0044754 autolysosome IEA
 cellular_componentGO:0071682 endocytic vesicle lumen TAS
 molecular_functionGO:0004322 ferroxidase activity IEA
 molecular_functionGO:0005506 iron ion binding IDA
 molecular_functionGO:0008199 ferric iron binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation
Iron uptake and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fth1tm1.2Lck/Fth1tm1.2Lck
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fth1tm1.2Lck/Fth1tm1.2Lck
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Fth1tm1.2Lck/Fth1tm1.2Lck
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Fth1tm1.2Lck/Fth1tm1.2Lck
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dnajc6tm1Legr/Dnajc6+
Genetic Background: B6.129-Dnajc6tm1Legr

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Dnajc6tm1Legr/Dnajc6+
Genetic Background: B6.129-Dnajc6tm1Legr

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Fth1tm1.2Lck/Fth1tm1.2Lck
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp2m267Asp/Lrp2m267Asp
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0005637 abnormal iron homeostasis "anomaly in the state of equilibrium in the body with respect to this metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64456]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL

Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Lrp2m267Asp/Lrp2m267Asp
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0008738 abnormal liver iron level "anomaly in the amount of iron present in the liver tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

 MP:0008808 decreased spleen iron level "reduction in the amount of iron present in the spleen tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lrp2m267Asp/Lrp2m267Asp
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fth1tm1.1Lck/Fth1tm1.1Lck,Tg(Mx1-cre)1Cgn/0
Genetic Background: B6.Cg-Fth1tm1.1Lck Tg(Mx1-cre)1Cgn

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Dnajc6tm1Legr/Dnajc6+
Genetic Background: B6.129-Dnajc6tm1Legr

Allelic Composition: Fth1tm1.2Lck/Fth1tm1.2Lck
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Fth1tm1.1Ruvi/Fth1tm1.1Ruvi,Ftl1tm1.1Ruvi/Ftl1tm1.1Ruvi
Genetic Background: involves: 129 * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0011890 increased circulating ferritin level "elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases" [MGI:csmith]
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Allelic Composition: Rbpjtm1Hon/Rbpjtm1Hon,Tg(MMTV-cre)1Mam/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * FVB * SJL

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024661 Fth1 / P09528 / Ferritin heavy chain Ferritin heavy chain, N-terminally processed / P02794* / ferritin heavy chain 1*  / complex
 ENSMUSG00000022032 Q8K299 / Scara5 / Scavenger receptor class A member 5 / Q6ZMJ2*  / complex / reaction
 ENSMUSG00000028580 Pum1 / Q80U78 / pumilio RNA-binding family member 1 / Q14671*  / complex
 ENSMUSG00000050708 Ftl1 / FTL* / P02792* / ferritin light chain*  / complex
 ENSMUSG00000028082 Q91X43 / Sh3d19 / SH3 domain-containing protein 19 / Q5HYK7* / SH3 domain containing 19*  / complex
 ENSMUSG00000006169 Clint1 / Mus musculus clathrin interactor 1 (Clint1), transcript variant 2, mRNA. / Q14677* / clathrin interactor 1*  / complex






 

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