ENSMUSG00000020608


Mus musculus

Features
Gene ID: ENSMUSG00000020608
  
Biological name :Smc6
  
Synonyms : Q924W5 / Smc6 / Structural maintenance of chromosomes protein 6
  
Possible biological names infered from orthology : Q96SB8 / structural maintenance of chromosomes 6
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A1.1
Gene start: 11265886
Gene end: 11319785
  
Corresponding Affymetrix probe sets: 10394560 (MoGene1.0st)   1417736_at (Mouse Genome 430 2.0 Array)   1422909_at (Mouse Genome 430 2.0 Array)   1422910_s_at (Mouse Genome 430 2.0 Array)   1448828_at (Mouse Genome 430 2.0 Array)   1448829_at (Mouse Genome 430 2.0 Array)   1460069_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151232
Ensembl peptide - ENSMUSP00000152041
Ensembl peptide - ENSMUSP00000151976
Ensembl peptide - ENSMUSP00000151643
Ensembl peptide - ENSMUSP00000151435
Ensembl peptide - ENSMUSP00000151382
Ensembl peptide - ENSMUSP00000151378
Ensembl peptide - ENSMUSP00000020931
NCBI entrez gene - 67241     See in Manteia.
MGI - MGI:1914491
RefSeq - XM_011243892
RefSeq - NM_001324476
RefSeq - NM_025695
RefSeq - XM_006515173
RefSeq Peptide - NP_079971
RefSeq Peptide - NP_001311405
swissprot - Q924W5
swissprot - A0A1W2P8E7
swissprot - A0A1W2P6W0
swissprot - A0A1W2P6V7
swissprot - A0A1W2P6F2
swissprot - A0A1W2P6T0
swissprot - A0A1W2P7G6
Ensembl - ENSMUSG00000020608
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 smc6ENSDARG00000091821Danio rerio
 SMC6ENSGALG00000016467Gallus gallus
 SMC6ENSG00000163029Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003395  RecF/RecN/SMC, N-terminal
 IPR027132  Structural maintenance of chromosomes protein 6
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000722 telomere maintenance via recombination ISS
 biological_processGO:0000724 double-strand break repair via homologous recombination IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0051984 positive regulation of chromosome segregation ISO
 biological_processGO:0090398 cellular senescence ISS
 cellular_componentGO:0000781 chromosome, telomeric region TAS
 cellular_componentGO:0000803 sex chromosome IDA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0016605 PML body TAS
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0030915 Smc5-Smc6 complex IEA
 cellular_componentGO:0035061 interchromatin granule ISO
 cellular_componentGO:0035861 site of double-strand break ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0000248 macrocytosis "condition in which erythrocytes are larger than normal in size" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0006086 decreased body mass index "less than normal average of a measure of weight for height " [ncbi:NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz,Tg(TcraTcrb)425Cbn/?
Genetic Background: involves: C57BL/6 * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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