ENSMUSG00000020673


Mus musculus

Features
Gene ID: ENSMUSG00000020673
  
Biological name :Tpo
  
Synonyms : P35419 / thyroid peroxidase / Tpo
  
Possible biological names infered from orthology : P07202
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: A2
Gene start: 30054659
Gene end: 30132624
  
Corresponding Affymetrix probe sets: 10399782 (MoGene1.0st)   1420600_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021005
Ensembl peptide - ENSMUSP00000133853
NCBI entrez gene - 22018     See in Manteia.
MGI - MGI:98813
RefSeq - NM_009417
RefSeq - XM_011243856
RefSeq Peptide - NP_033443
swissprot - G3UXW8
swissprot - P35419
Ensembl - ENSMUSG00000020673
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TPOENSGALG00000016370Gallus gallus
 TPOENSG00000115705Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mpo / P11247 / Myeloperoxidase Myeloperoxidase light chain Myeloperoxidase heavy chain / P05164* / myeloperoxidase*ENSMUSG0000000935034
Pxdn / Q3UQ28 / Peroxidasin homolog / Q92626* / peroxidasin*ENSMUSG0000002067433
Epx / P49290 / Eosinophil peroxidase Eosinophil peroxidase light chain Eosinophil peroxidase heavy chain / P11678* / eosinophil peroxidase*ENSMUSG0000005223433
Lpo / lactoperoxidase / P22079*ENSMUSG0000000935631


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000436  Sushi/SCR/CCP domain
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR010255  Haem peroxidase
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR019791  Haem peroxidase, animal type
 IPR029589  Thyroid peroxidase
 IPR035976  Sushi/SCR/CCP superfamily
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006590 thyroid hormone generation IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0042446 hormone biosynthetic process IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004447 iodide peroxidase activity IEA
 molecular_functionGO:0004601 peroxidase activity IBA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Thyroxine biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000031 abnormal cochlea morphology "any anomaly, deformity, malformation, impairment or dysfunction of the cochlea" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:21484]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0000559 abnormal femur morphology "structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

 MP:0000681 abnormal thyroid gland morphology "anomalous structure of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0000692 small spleen "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0002750 exophthalmos "protrusion of one or both eyeballs" [J:47965, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0002876 abnormal thyroid physiology "anomalous function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0002951 small thyroid gland "reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0003149 abnormal tectorial membrane morphology "malformation, malfunction or absence of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:77634]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0003421 abnormal thyroid gland development "failure or abnormality in the formation of the thyroid gland during organogenesis" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95017]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0003503 decreased activity of thyroid 
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0004664 delayed inner ear development "slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Flt1tm1Jrt/Flt1tm1.2Fong
Genetic Background: involves: 129 * C57BL/6NCr * CD-1

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0004696 abnormal thyroid follicle morphology "any structural abnormality of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

Allelic Composition: Tpotee/Tpotee
Genetic Background: C57BL/6J-Tpotee/GrsrJ

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

 MP:0004697 abnormal thyroid follicular cell "any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0005122 increased circulating thyroid-stimulating hormone level "greater than expected blood concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0005355 enlarged thyroid gland "increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:85158, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tpotee/Tpotee
Genetic Background: C57BL/6J-Tpotee/GrsrJ

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: C3.B6(NOD)-Tpotee-2J/Kjn

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Tpotee/Tpotee
Genetic Background: C57BL/6J-Tpotee/GrsrJ

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: B6.Cg-Tpotee-2J H2g7/GrsrJ

Allelic Composition: Tpotee-2J/Tpotee-2J
Genetic Background: C3.B6(NOD)-Tpotee-2J/Kjn

 MP:0030049 prominent forehead "forward prominence of the entire forehead, due to protrusion of the frontal bone; not to be confused with frontal bossing" [HP:0011220]
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Allelic Composition: Lmx1adr-J/Lmx1adr-J
Genetic Background: C3FeB6 A/Aw-J-Ankank Lmx1adr-J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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