ENSMUSG00000020674


Mus musculus

Features
Gene ID: ENSMUSG00000020674
  
Biological name :Pxdn
  
Synonyms : Peroxidasin homolog / Pxdn / Q3UQ28
  
Possible biological names infered from orthology : peroxidasin / Q92626
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: A2
Gene start: 29937608
Gene end: 30017658
  
Corresponding Affymetrix probe sets: 10395103 (MoGene1.0st)   1428259_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113477
Ensembl peptide - ENSMUSP00000151320
Ensembl peptide - ENSMUSP00000113703
NCBI entrez gene - 69675     See in Manteia.
MGI - MGI:1916925
RefSeq - NM_181395
RefSeq - XM_006515205
RefSeq Peptide - NP_852060
swissprot - D3Z5M7
swissprot - Q3UQ28
swissprot - A0A1W2P6L9
Ensembl - ENSMUSG00000020674
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pxdnENSDARG00000098733Danio rerio
 PXDNENSGALG00000016377Gallus gallus
 PXDNENSG00000130508Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epx / P49290 / Eosinophil peroxidase Eosinophil peroxidase light chain Eosinophil peroxidase heavy chain / P11678* / eosinophil peroxidase*ENSMUSG0000005223420
Tpo / P35419 / thyroid peroxidase / P07202*ENSMUSG0000002067320
Mpo / P11247 / Myeloperoxidase Myeloperoxidase light chain Myeloperoxidase heavy chain / P05164* / myeloperoxidase*ENSMUSG0000000935020
Lpo / lactoperoxidase / P22079*ENSMUSG0000000935618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001007  VWFC domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR010255  Haem peroxidase
 IPR013098  Immunoglobulin I-set
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR019791  Haem peroxidase, animal type
 IPR032675  Leucine-rich repeat domain superfamily
 IPR034824  Peroxidasin, peroxidase domain
 IPR034828  Peroxidasin
 IPR036179  Immunoglobulin-like domain superfamily
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0042744 hydrogen peroxide catabolic process ISS
 biological_processGO:0055114 oxidation-reduction process ISO
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004601 peroxidase activity IBA
 molecular_functionGO:0005201 extracellular matrix structural constituent IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Crosslinking of collagen fibrils


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001306 small lens "reduced size of the transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001330 abnormal optic nerve morphology "malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0001851 eye inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the eye" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0002579 disorganized secondary lens fibers "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0005193 abnormal anterior eye segment morphology "anomalous structure of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0005299 abnormal eye posterior chamber "anomaly of the ringlike space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0005300 abnormal corneal stroma morphology "structural anomaly of the lamellated connective tissue of the cornea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0006000 abnormal corneal epithelium "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0006200 vitreous body deposition "abnormal accumulation of material in the vitreous body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0006221 optic nerve hypoplasia "less than the normal number of fibers in the optic nerve" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0006226 iris hypoplasia "less than the normal number of cells in the iris" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0006309 decreased retinal ganglion cell number "reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0008841 ruptured lens capsule "a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0009392 retinal gliosis "increased proliferation of neuroglia in a damaged area of the retina that may lead to the formation of scar tissue" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0009742 increased corneal stroma thickness "increased width of the lamellated connective tissue layer of the cornea" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0010235 abnormal retina inner limiting membrane morphology "any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0010709 absent anterior chamber "absence of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MESH:A09.371.060.067]
Show

Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0010713 corneal-lenticular stalk "persistent central adhesion between the lens and the cornea" [PMID:18653562]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0011960 abnormal eye anterior chamber depth "anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the anterior chamber, compared to controls" [MGI:csmith]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0013258 abnormal extracellular matrix morphology "any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell " [GO:0031012]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

 MP:0013743 ciliary body hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the thickened portion of the vascular tunic which lies between the choroid and the iris" [ISBN:0-683-40008-8, MGI:Anna]
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Allelic Composition: Gcm2tm1.2Malx/Gcm2tm1.2Malx
Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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