ENSMUSG00000009350


Mus musculus

Features
Gene ID: ENSMUSG00000009350
  
Biological name :Mpo
  
Synonyms : Mpo / Myeloperoxidase Myeloperoxidase light chain Myeloperoxidase heavy chain / P11247
  
Possible biological names infered from orthology : myeloperoxidase / P05164
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 87793581
Gene end: 87804413
  
Corresponding Affymetrix probe sets: 10380174 (MoGene1.0st)   1415960_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123371
Ensembl peptide - ENSMUSP00000128484
Ensembl peptide - ENSMUSP00000020779
Ensembl peptide - ENSMUSP00000103563
Ensembl peptide - ENSMUSP00000112837
NCBI entrez gene - 17523     See in Manteia.
MGI - MGI:97137
RefSeq - NM_010824
RefSeq Peptide - NP_034954
swissprot - F7DC05
swissprot - F8WGZ9
swissprot - A0A0A0MQL9
swissprot - P11247
Ensembl - ENSMUSG00000009350
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpxENSDARG00000019521Danio rerio
 ENSGALG00000043254Gallus gallus
 MPOENSG00000005381Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Epx / P49290 / Eosinophil peroxidase Eosinophil peroxidase light chain Eosinophil peroxidase heavy chain / P11678* / eosinophil peroxidase*ENSMUSG0000005223467
Lpo / lactoperoxidase / P22079*ENSMUSG0000000935650
Tpo / P35419 / thyroid peroxidase / P07202*ENSMUSG0000002067343
Pxdn / Q3UQ28 / Peroxidasin homolog / Q92626* / peroxidasin*ENSMUSG0000002067441


Protein motifs (from Interpro)
Interpro ID Name
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029609  Myeloperoxidase
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001878 response to yeast IMP
 biological_processGO:0002149 hypochlorous acid biosynthetic process IEA
 biological_processGO:0002679 respiratory burst involved in defense response IMP
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0019430 removal of superoxide radicals IMP
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling ISO
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IMP
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1990268 response to gold nanoparticle IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0030141 secretory granule ISO
 cellular_componentGO:0042582 azurophil granule ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0008201 heparin binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gusbmps/Gusbmps
Genetic Background: B6.Cg-Gusbmps/BrkJ

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: B6.129X1-Mpotm1Lus

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: B6.129X1-Mpotm1Lus

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: B6.129X1-Mpotm1Lus

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpotm1Lus/Mpotm1Lus
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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