ENSG00000005381


Homo sapiens

Features
Gene ID: ENSG00000005381
  
Biological name :MPO
  
Synonyms : MPO / myeloperoxidase / P05164
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q22
Gene start: 58269856
Gene end: 58280935
  
Corresponding Affymetrix probe sets: 203948_s_at (Human Genome U133 Plus 2.0 Array)   203949_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000225275
Ensembl peptide - ENSP00000464668
NCBI entrez gene - 4353     See in Manteia.
OMIM - 606989
RefSeq - NM_000250
RefSeq Peptide - NP_000241
swissprot - P05164
swissprot - J3QSF7
Ensembl - ENSG00000005381
  
Related genetic diseases (OMIM): 104300 - {Alzheimer disease, susceptibility to}, 104300
  254600 - Myeloperoxidase deficiency, 254600
  606989 - {Lung cancer, protection against, in smokers}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpxENSDARG00000019521Danio rerio
 ENSGALG00000043254Gallus gallus
 MpoENSMUSG00000009350Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPX / P11678 / eosinophil peroxidaseENSG0000012105367
LPO / P22079 / lactoperoxidaseENSG0000016741950
TPO / P07202 / thyroid peroxidaseENSG0000011570542
PXDN / Q92626 / peroxidasinENSG0000013050840
PXDNL / A1KZ92 / peroxidasin likeENSG0000014748536


Protein motifs (from Interpro)
Interpro ID Name
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029609  Myeloperoxidase
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001878 response to yeast IEA
 biological_processGO:0002149 hypochlorous acid biosynthetic process IEA
 biological_processGO:0002679 respiratory burst involved in defense response IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0019430 removal of superoxide radicals IEA
 biological_processGO:0032094 response to food IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034374 low-density lipoprotein particle remodeling IDA
 biological_processGO:0042742 defense response to bacterium IBA
 biological_processGO:0042744 hydrogen peroxide catabolic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:1990268 response to gold nanoparticle IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005764 lysosome TAS
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0042582 azurophil granule IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003682 chromatin binding TAS
 molecular_functionGO:0004601 peroxidase activity IEA
 molecular_functionGO:0008201 heparin binding IDA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000007 Autosomal recessive inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in homozygotes. In the context of medical genetics, autosomal recessive disorders manifest in homozygotes (with two copies of the mutant allele) or compound heterozygotes (whereby each copy of a gene has a distinct mutant allele)." [HPO:curators]
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 HP:0001871 Hematological abnormality 
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 HP:0001939 Metabolism abnormality 
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 HP:0002715 Immunological abnormality 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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