ENSG00000121053


Homo sapiens

Features
Gene ID: ENSG00000121053
  
Biological name :EPX
  
Synonyms : eosinophil peroxidase / EPX / P11678
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q22
Gene start: 58192737
Gene end: 58205174
  
Corresponding Affymetrix probe sets: 214627_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000225371
NCBI entrez gene - 8288     See in Manteia.
OMIM - 131399
RefSeq - NM_000502
RefSeq Peptide - NP_000493
swissprot - P11678
Ensembl - ENSG00000121053
  
Related genetic diseases (OMIM): 261500 - [Eosinophil peroxidase deficiency], 261500
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mpxENSDARG00000019521Danio rerio
 ENSGALG00000043254Gallus gallus
 EpxENSMUSG00000052234Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MPO / P05164 / myeloperoxidaseENSG0000000538170
LPO / P22079 / lactoperoxidaseENSG0000016741952
TPO / P07202 / thyroid peroxidaseENSG0000011570545
PXDN / Q92626 / peroxidasinENSG0000013050842
PXDNL / A1KZ92 / peroxidasin likeENSG0000014748539


Protein motifs (from Interpro)
Interpro ID Name
 IPR010255  Haem peroxidase
 IPR019791  Haem peroxidase, animal type
 IPR029599  Eosinophil peroxidase
 IPR037120  Haem peroxidase domain superfamily, animal type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002215 defense response to nematode IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0032693 negative regulation of interleukin-10 production IEA
 biological_processGO:0032714 negative regulation of interleukin-5 production IEA
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0042744 hydrogen peroxide catabolic process IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0072677 eosinophil migration IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004601 peroxidase activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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