ENSMUSG00000020733


Mus musculus

Features
Gene ID: ENSMUSG00000020733
  
Biological name :Slc9a3r1
  
Synonyms : P70441 / Slc9a3r1 / solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
  
Possible biological names infered from orthology : O14745 / SLC9A3 regulator 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E2
Gene start: 115163341
Gene end: 115181181
  
Corresponding Affymetrix probe sets: 10382462 (MoGene1.0st)   1438115_a_at (Mouse Genome 430 2.0 Array)   1438116_x_at (Mouse Genome 430 2.0 Array)   1450982_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021077
NCBI entrez gene - 26941     See in Manteia.
MGI - MGI:1349482
RefSeq - NM_012030
RefSeq Peptide - NP_036160
swissprot - P70441
swissprot - Q3TG37
Ensembl - ENSMUSG00000020733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slc9a3r1aENSDARG00000000068Danio rerio
 SLC9A3R1ENSGALG00000007650Gallus gallus
 O14745ENSG00000109062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slc9a3r2 / solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 / Q15599* / SLC9A3 regulator 2*ENSMUSG0000000250448
Pdzk1 / Na(+)/H(+) exchange regulatory cofactor NHE-RF3 / Q5T2W1* / PDZ domain containing 1*ENSMUSG0000003829830
Pdzd3 / PDZ domain containing 3 / Q86UT5*ENSMUSG0000003210527


Protein motifs (from Interpro)
Interpro ID Name
 IPR001478  PDZ domain
 IPR015098  EBP50, C-terminal
 IPR017300  Na(+)/H(+) exchange regulatory cofactor NHERF
 IPR031199  Na(+)/H(+) exchange regulatory cofactor NHERF-1
 IPR036034  PDZ superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003096 renal sodium ion transport IMP
 biological_processGO:0007097 nuclear migration IEA
 biological_processGO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway IMP
 biological_processGO:0007605 sensory perception of sound IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0008361 regulation of cell size IEA
 biological_processGO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway IMP
 biological_processGO:0010766 negative regulation of sodium ion transport IMP
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0019933 cAMP-mediated signaling ISA
 biological_processGO:0022612 gland morphogenesis IEA
 biological_processGO:0030033 microvillus assembly IEA
 biological_processGO:0030036 actin cytoskeleton organization IMP
 biological_processGO:0030336 negative regulation of cell migration IGI
 biological_processGO:0030643 cellular phosphate ion homeostasis IMP
 biological_processGO:0032416 negative regulation of sodium:proton antiporter activity IMP
 biological_processGO:0032782 bile acid secretion IMP
 biological_processGO:0034613 cellular protein localization IMP
 biological_processGO:0034635 glutathione transport IMP
 biological_processGO:0044062 regulation of excretion IMP
 biological_processGO:0045198 establishment of epithelial cell apical/basal polarity IEA
 biological_processGO:0045859 regulation of protein kinase activity IMP
 biological_processGO:0045930 negative regulation of mitotic cell cycle IEA
 biological_processGO:0051683 establishment of Golgi localization IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0060088 auditory receptor cell stereocilium organization IMP
 biological_processGO:0060158 phospholipase C-activating dopamine receptor signaling pathway IMP
 biological_processGO:0070293 renal absorption IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:0097291 renal phosphate ion absorption IEA
 biological_processGO:2000146 negative regulation of cell motility ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005902 microvillus ISS
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031526 brush border membrane IDA
 cellular_componentGO:0031528 microvillus membrane IEA
 cellular_componentGO:0032420 stereocilium IDA
 cellular_componentGO:0032426 stereocilium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0071944 cell periphery IEA
 cellular_componentGO:0097225 sperm midpiece IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008013 beta-catenin binding IEA
 molecular_functionGO:0017081 chloride channel regulator activity IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0030165 PDZ domain binding IEA
 molecular_functionGO:0031698 beta-2 adrenergic receptor binding IEA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0045159 myosin II binding IEA
 molecular_functionGO:0050780 dopamine receptor binding IDA
 molecular_functionGO:0070851 growth factor receptor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Htra2mnd2/Htra2mnd2
Genetic Background: B6.Cg-Htra2mnd2

Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Slc9a3r1tm1Geo/Slc9a3r1tm1Geo
Genetic Background: involves: C57BL/6J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

 MP:0008872 abnormal response to xenobiotics "any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jak3tm1Ljb/Jak3tm1Ljb,Tg(Lck-Jak3)2Ljb/0
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/10

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: FVB.129-Slc9a3r1tm1Ssl

Allelic Composition: Cftrtm1Eur/Cftrtm1Eur,Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Slc9a3r1tm1Ssl/Slc9a3r1tm1Ssl
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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