ENSMUSG00000021068


Mus musculus

Features
Gene ID: ENSMUSG00000021068
  
Biological name :Nin
  
Synonyms : Nin / Ninein / Q61043
  
Possible biological names infered from orthology : Q8N4C6
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: C2
Gene start: 70011435
Gene end: 70113717
  
Corresponding Affymetrix probe sets: 10400805 (MoGene1.0st)   1419078_at (Mouse Genome 430 2.0 Array)   1428600_at (Mouse Genome 430 2.0 Array)   1444155_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000129648
Ensembl peptide - ENSMUSP00000152553
Ensembl peptide - ENSMUSP00000152530
Ensembl peptide - ENSMUSP00000152395
Ensembl peptide - ENSMUSP00000152350
Ensembl peptide - ENSMUSP00000152240
Ensembl peptide - ENSMUSP00000152096
Ensembl peptide - ENSMUSP00000021468
Ensembl peptide - ENSMUSP00000082422
Ensembl peptide - ENSMUSP00000093327
NCBI entrez gene - 18080     See in Manteia.
MGI - MGI:105108
RefSeq - XM_011244009
RefSeq - XM_006515532
RefSeq - XM_006515530
RefSeq - XM_006515529
RefSeq - XM_006515528
RefSeq - NM_001081453
RefSeq - NM_001286079
RefSeq - NM_001286080
RefSeq - XM_006515527
RefSeq - NM_008697
RefSeq Peptide - NP_001074922
RefSeq Peptide - NP_001273008
RefSeq Peptide - NP_001273009
RefSeq Peptide - NP_032723
swissprot - Q61043
swissprot - E9Q4S3
swissprot - A0A1Y7VIQ3
swissprot - A0A1Y7VJC3
swissprot - A0A1Y7VJL5
swissprot - A0A1Y7VJS5
swissprot - A0A1Y7VNC5
Ensembl - ENSMUSG00000021068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ninENSDARG00000060298Danio rerio
 NINENSGALG00000012361Gallus gallus
 NINENSG00000100503Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ninl / Q6ZQ12 / Ninein-like protein / Q9Y2I6* / ninein like*ENSMUSG0000006811520


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR029664  Ninein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008104 protein localization ISO
 biological_processGO:0010457 centriole-centriole cohesion ISO
 biological_processGO:0021540 corpus callosum morphogenesis IGI
 biological_processGO:0021957 corticospinal tract morphogenesis IGI
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0034454 microtubule anchoring at centrosome ISS
 biological_processGO:0048668 collateral sprouting IGI
 biological_processGO:0050772 positive regulation of axonogenesis IGI
 biological_processGO:0051642 centrosome localization IMP
 biological_processGO:0090222 centrosome-templated microtubule nucleation IMP
 cellular_componentGO:0000242 pericentriolar material IBA
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005814 centriole IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0036449 microtubule minus-end IDA
 cellular_componentGO:0044295 axonal growth cone IDA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0072686 mitotic spindle ISO
 cellular_componentGO:0097431 mitotic spindle pole IDA
 cellular_componentGO:0097539 ciliary transition fiber IDA
 cellular_componentGO:0120103 centriolar subdistal appendage ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019900 kinase binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0005385 cardiovascular system phenotype 
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Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Mthfd1tm2b(KOMP)Wtsi/Mthfd1tm2b(KOMP)Wtsi
Genetic Background: C57BL/6N-Mthfd1tm2b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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