ENSMUSG00000021171


Mus musculus

Features
Gene ID: ENSMUSG00000021171
  
Biological name :Esyt2
  
Synonyms : Esyt2 / Extended synaptotagmin-2 / Q3TZZ7
  
Possible biological names infered from orthology : A0FGR8
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F2
Gene start: 116281196
Gene end: 116391050
  
Corresponding Affymetrix probe sets: 10399061 (MoGene1.0st)   1428408_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152786
Ensembl peptide - ENSMUSP00000098548
Ensembl peptide - ENSMUSP00000152311
Ensembl peptide - ENSMUSP00000152444
NCBI entrez gene - 52635     See in Manteia.
MGI - MGI:1261845
RefSeq - XM_017315131
RefSeq - XM_011244139
RefSeq - XM_017315128
RefSeq - XM_017315129
RefSeq - XM_017315130
RefSeq - NM_028731
RefSeq - XM_006516072
RefSeq Peptide - NP_083007
swissprot - A0A1Y7VNA1
swissprot - A0A1Y7VM39
swissprot - Q3TZZ7
Ensembl - ENSMUSG00000021171
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esyt2aENSDARG00000030824Danio rerio
 esyt2bENSDARG00000078964Danio rerio
 ESYT2ENSGALG00000006542Gallus gallus
 ESYT2ENSG00000117868Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Esyt1 / Q3U7R1 / Extended synaptotagmin-1 / Q9BSJ8*ENSMUSG0000002536645
Esyt3 / Q5DTI8 / Extended synaptotagmin-3 / A0FGR9*ENSMUSG0000003768141
Mctp1 / E9PV86 / Multiple C2 and transmembrane domain-containing protein 1 / Q6DN14* / multiple C2 and transmembrane domain containing 1*ENSMUSG0000002159615
Mctp2 / Q5RJH2 / Multiple C2 and transmembrane domain-containing protein 2 / Q6DN12* / multiple C2 and transmembrane domain containing 2*ENSMUSG0000003277614


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR031468  Synaptotagmin-like mitochondrial-lipid-binding domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0061817 endoplasmic reticulum-plasma membrane tethering IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031227 intrinsic component of endoplasmic reticulum membrane IBA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISO
 cellular_componentGO:0044232 organelle membrane contact site ISO
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005544 calcium-dependent phospholipid binding ISO
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding ISS
 molecular_functionGO:0031210 phosphatidylcholine binding ISS
 molecular_functionGO:0035091 phosphatidylinositol binding ISS
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pofut2tm2.2Bch/Pofut2tm2.2Bch
Genetic Background: B6.Cg-Pofut2tm2.2Bch

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pitpnavb/Pitpnavb
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
Show

Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

Allelic Composition: Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi,Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037681 Esyt3 / Q5DTI8 / Extended synaptotagmin-3 / A0FGR9*  / complex
 ENSMUSG00000025366 Esyt1 / Q3U7R1 / Extended synaptotagmin-1 / Q9BSJ8*  / complex






 

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