ENSMUSG00000037681


Mus musculus

Features
Gene ID: ENSMUSG00000037681
  
Biological name :Esyt3
  
Synonyms : Esyt3 / Extended synaptotagmin-3 / Q5DTI8
  
Possible biological names infered from orthology : A0FGR9
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.3
Gene start: 99309963
Gene end: 99358557
  
Corresponding Affymetrix probe sets: 10595953 (MoGene1.0st)   1456481_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038757
Ensembl peptide - ENSMUSP00000140567
NCBI entrez gene - 272636     See in Manteia.
MGI - MGI:1098699
RefSeq - XM_011242752
RefSeq - NM_177775
RefSeq - XM_006511221
RefSeq Peptide - NP_808443
swissprot - Q5DTI8
swissprot - A0A087WRC5
Ensembl - ENSMUSG00000037681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esyt3ENSDARG00000006422Danio rerio
 ESYT3ENSGALG00000012092Gallus gallus
 ESYT3ENSG00000158220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Esyt2 / Q3TZZ7 / Extended synaptotagmin-2 / A0FGR8*ENSMUSG0000002117139
Esyt1 / Q3U7R1 / Extended synaptotagmin-1 / Q9BSJ8*ENSMUSG0000002536637
Mctp2 / Q5RJH2 / Multiple C2 and transmembrane domain-containing protein 2 / Q6DN12* / multiple C2 and transmembrane domain containing 2*ENSMUSG0000003277613
Mctp1 / E9PV86 / Multiple C2 and transmembrane domain-containing protein 1 / Q6DN14* / multiple C2 and transmembrane domain containing 1*ENSMUSG0000002159613


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR031468  Synaptotagmin-like mitochondrial-lipid-binding domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0061817 endoplasmic reticulum-plasma membrane tethering IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031227 intrinsic component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0044232 organelle membrane contact site IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi,Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Nsdhltm1.1Hrm/Y,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6N * CBA

 MP:0011805 decreased cell migration "reduced or slower movement of cells from one site to another, often occuring during developmental or chemotactic processes" [GO:0016477, MGI:csmith]
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Allelic Composition: Esyt2Gt(AN0678)Wtsi/Esyt2Gt(AN0678)Wtsi,Esyt3tm1d(EUCOMM)Wtsi/Esyt3tm1d(EUCOMM)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021171 Esyt2 / Q3TZZ7 / Extended synaptotagmin-2 / A0FGR8*  / complex
 ENSMUSG00000025366 Esyt1 / Q3U7R1 / Extended synaptotagmin-1 / Q9BSJ8*  / complex






 

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