ENSG00000117868


Homo sapiens

Features
Gene ID: ENSG00000117868
  
Biological name :ESYT2
  
Synonyms : A0FGR8 / ESYT2 / extended synaptotagmin 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q36.3
Gene start: 158730995
Gene end: 158830253
  
Corresponding Affymetrix probe sets: 1555829_at (Human Genome U133 Plus 2.0 Array)   1555830_s_at (Human Genome U133 Plus 2.0 Array)   1558511_s_at (Human Genome U133 Plus 2.0 Array)   224698_at (Human Genome U133 Plus 2.0 Array)   224699_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000251527
Ensembl peptide - ENSP00000481296
Ensembl peptide - ENSP00000275418
NCBI entrez gene - 57488     See in Manteia.
OMIM - 616691
RefSeq - NM_020728
RefSeq Peptide - NP_065779
swissprot - A0FGR8
swissprot - A0A087WXU3
swissprot - H7BXI1
Ensembl - ENSG00000117868
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 esyt2aENSDARG00000030824Danio rerio
 esyt2bENSDARG00000078964Danio rerio
 ESYT2ENSGALG00000006542Gallus gallus
 Esyt2ENSMUSG00000021171Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ESYT1 / Q9BSJ8 / extended synaptotagmin 1ENSG0000013964143
ESYT3 / A0FGR9 / extended synaptotagmin 3ENSG0000015822039
MCTP1 / Q6DN14 / multiple C2 and transmembrane domain containing 1ENSG0000017547115
MCTP2 / Q6DN12 / multiple C2 and transmembrane domain containing 2ENSG0000014056314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR031468  Synaptotagmin-like mitochondrial-lipid-binding domain
 IPR035892  C2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006687 glycosphingolipid metabolic process TAS
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0061817 endoplasmic reticulum-plasma membrane tethering IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031227 intrinsic component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IMP
 cellular_componentGO:0044232 organelle membrane contact site IDA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0008429 phosphatidylethanolamine binding IDA
 molecular_functionGO:0031210 phosphatidylcholine binding IDA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139641 ESYT1 / Q9BSJ8 / extended synaptotagmin 1  / complex
 ENSG00000158220 ESYT3 / A0FGR9 / extended synaptotagmin 3  / complex






 

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