ENSMUSG00000021311


Mus musculus

Features
Gene ID: ENSMUSG00000021311
  
Biological name :Mtr
  
Synonyms : A6H5Y3 / Methionine synthase / Mtr
  
Possible biological names infered from orthology : 5-methyltetrahydrofolate-homocysteine methyltransferase / Q99707
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: A1
Gene start: 12182712
Gene end: 12258113
  
Corresponding Affymetrix probe sets: 10407707 (MoGene1.0st)   10407709 (MoGene1.0st)   1439811_at (Mouse Genome 430 2.0 Array)   1441139_at (Mouse Genome 430 2.0 Array)   1458532_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097442
Ensembl peptide - ENSMUSP00000152579
NCBI entrez gene - 238505     See in Manteia.
MGI - MGI:894292
RefSeq - NM_001081128
RefSeq - XM_006516661
RefSeq - XM_006516662
RefSeq Peptide - NP_001074597
swissprot - A6H5Y3
swissprot - A0A1Y7VM88
Ensembl - ENSMUSG00000021311
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mtrENSDARG00000104906Danio rerio
 MTRENSGALG00000014464Gallus gallus
 MTRENSG00000116984Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000489  Pterin-binding domain
 IPR003726  Homocysteine-binding domain
 IPR003759  Cobalamin (vitamin B12)-binding module, cap domain
 IPR004223  Vitamin B12-dependent methionine synthase, activation domain
 IPR006158  Cobalamin (vitamin B12)-binding domain
 IPR011005  Dihydropteroate synthase-like
 IPR011822  Cobalamin-dependent methionine synthase
 IPR033706  Methionine synthase, B12-binding domain
 IPR036589  Homocysteine-binding domain superfamily
 IPR036594  Methionine synthase domain
 IPR036724  Cobalamin-binding domain superfamily
 IPR037010  Vitamin B12-dependent methionine synthase, activation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0009086 methionine biosynthetic process ISO
 biological_processGO:0009235 cobalamin metabolic process IEA
 biological_processGO:0031103 axon regeneration IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0042558 pteridine-containing compound metabolic process IEA
 biological_processGO:0044237 cellular metabolic process IEA
 biological_processGO:0048678 response to axon injury IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008705 methionine synthase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031419 cobalamin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Methylation
Sulfur amino acid metabolism
Cobalamin (Cbl, vitamin B12) transport and metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cx3cr1tm1Ifc/Cx3cr1tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Mtrtm1Lcb/Mtr+
Genetic Background: involves: 129S/SvEv * Black Swiss

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Hrastm1Esn/Hrastm1Esn,Nrastm1Rak/Nrastm1Rak
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * C57BL/6N

Allelic Composition: Mtrtm1Lcb/Mtrtm1Lcb
Genetic Background: involves: 129S/SvEv * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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