ENSMUSG00000021456


Mus musculus

Features
Gene ID: ENSMUSG00000021456
  
Biological name :Fbp2
  
Synonyms : Fbp2 / Fructose-1,6-bisphosphatase isozyme 2 / P70695
  
Possible biological names infered from orthology : fructose-bisphosphatase 2 / O00757
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: B3
Gene start: 62836877
Gene end: 62858422
  
Corresponding Affymetrix probe sets: 10409999 (MoGene1.0st)   1449088_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021907
NCBI entrez gene - 14120     See in Manteia.
MGI - MGI:95491
RefSeq - NM_007994
RefSeq Peptide - NP_032020
swissprot - P70695
swissprot - Q3TKP4
Ensembl - ENSMUSG00000021456
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fbp2ENSDARG00000012366Danio rerio
 FBP2ENSGALG00000012612Gallus gallus
 FBP2ENSG00000130957Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fbp1 / Q9QXD6 / Fructose-1,6-bisphosphatase 1 / P09467* / fructose-bisphosphatase 1*ENSMUSG0000006980571


Protein motifs (from Interpro)
Interpro ID Name
 IPR000146  Fructose-1,6-bisphosphatase class 1
 IPR020548  Fructose-1,6-bisphosphatase, active site
 IPR028343  Fructose-1,6-bisphosphatase
 IPR033391  Fructose-1-6-bisphosphatase class I, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0005986 sucrose biosynthetic process IBA
 biological_processGO:0006000 fructose metabolic process IBA
 biological_processGO:0006002 fructose 6-phosphate metabolic process IBA
 biological_processGO:0006094 gluconeogenesis IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0030388 fructose 1,6-bisphosphate metabolic process IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016791 phosphatase activity IEA
 molecular_functionGO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity IBA
 molecular_functionGO:0042578 phosphoric ester hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Gluconeogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Faddtm1e.1(KOMP)Wtsi/Faddtm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Faddtm1e.1(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021456 Fbp2 / P70695 / Fructose-1,6-bisphosphatase isozyme 2 / O00757* / fructose-bisphosphatase 2*  / complex






 

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