ENSMUSG00000021483


Mus musculus

Features
Gene ID: ENSMUSG00000021483
  
Biological name :Cdk20
  
Synonyms : Cdk20 / Cyclin-dependent kinase 20 / Q9JHU3
  
Possible biological names infered from orthology : Q8IZL9
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B3
Gene start: 64432314
Gene end: 64441773
  
Corresponding Affymetrix probe sets: 10405822 (MoGene1.0st)   1422494_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021939
Ensembl peptide - ENSMUSP00000152809
Ensembl peptide - ENSMUSP00000152606
Ensembl peptide - ENSMUSP00000152554
Ensembl peptide - ENSMUSP00000152425
Ensembl peptide - ENSMUSP00000152171
NCBI entrez gene - 105278     See in Manteia.
MGI - MGI:2145349
RefSeq - XM_006517033
RefSeq - NM_053180
RefSeq Peptide - NP_444410
swissprot - A0A1Y7VIW8
swissprot - A0A1Y7VKB8
swissprot - A0A1Y7VJE1
swissprot - Q9JHU3
swissprot - A0A1Y7VJN2
swissprot - A0A1Y7VNS6
Ensembl - ENSMUSG00000021483
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdk20ENSDARG00000003867Danio rerio
 CDK20ENSG00000156345Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*ENSMUSG0000006908941
Cdkl2 / Q9QUK0 / Cyclin-dependent kinase-like 2 / Q92772*ENSMUSG0000002940335
Cdkl1 / Q8CEQ0 / Cyclin-dependent kinase-like 1 / Q00532*ENSMUSG0000002099034
Cdkl5 / Q3UTQ8 / Cyclin-dependent kinase-like 5 / O76039*ENSMUSG0000003129234
Cdkl4 / Q3TZA2 / Cyclin-dependent kinase-like 4 / Q5MAI5*ENSMUSG0000003396632
Cdkl3 / Q8BLF2 / Cyclin-dependent kinase-like 3 / Q8IVW4*ENSMUSG0000002038931


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0051301 cell division IEA
 biological_processGO:1904031 positive regulation of cyclin-dependent protein kinase activity IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005675 holo TFIIH complex IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070985 TFIIK complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019912 cyclin-dependent protein kinase activating kinase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000552 abnormal radius morphology "malformation of the short bone of the lateral forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0000925 abnormal floor plate morphology "malformation or absence of a transient group of neuroepithelial cells located at the ventral midline of the neural tube that profoundly influences the development of the vertebrate central nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0000926 absent floor plate "missing ventral midline thinning of the developing neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35802]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Rab23opb2/Rab23opb2
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Rab23opb2/Rab23opb2
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Gli2tm1Alj/Gli2tm1Alj
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N

Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S7/SvEvBrd * C3H/HeJ * FVB/N

 MP:0004979 abnormal neuronal precursor cell number "deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk20tm1.1Jegg/Cdk20tm1.1Jegg,Rab23opb2/Rab23opb2
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/N

 MP:0005108 abnormal ulna morphology "malformation of the medial and larger of the two bones of the forearm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0009743 preaxial polydactyly "duplication of all or part of the first ray on one or more of the autopods" [PMID:19125433]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0013202 abnormal cilium morphology "any structural anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole " [GO:0005929]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0013210 abnormal primary cilium physiology "any functional anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors" [GO:0072372]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0013213 abnormal embryonic neuroepithelium primary cilium morphology "any structural anomaly of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning " [PMID:23351466]
Show

Allelic Composition: Card11M4Btlr/Card11+
Genetic Background: C57BL/6J-Card11M4Btlr

 MP:0014134 abnormal embryo morphology "any structural anomaly of an embryo " [MGI:csmith]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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