ENSMUSG00000031292


Mus musculus

Features
Gene ID: ENSMUSG00000031292
  
Biological name :Cdkl5
  
Synonyms : Cdkl5 / Cyclin-dependent kinase-like 5 / Q3UTQ8
  
Possible biological names infered from orthology : O76039
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F4
Gene start: 160771923
Gene end: 160994704
  
Corresponding Affymetrix probe sets: 10607619 (MoGene1.0st)   1429625_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000084342
Ensembl peptide - ENSMUSP00000143726
Ensembl peptide - ENSMUSP00000143137
Ensembl peptide - ENSMUSP00000143057
NCBI entrez gene - 382253     See in Manteia.
MGI - MGI:1278336
RefSeq - NM_001024624
RefSeq Peptide - NP_001019795
swissprot - A0A0G2JFE2
swissprot - A0A0G2JF79
swissprot - A0A0G2JGW6
swissprot - Q3UTQ8
Ensembl - ENSMUSG00000031292
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cdkl5ENSDARG00000015240Danio rerio
 CDKL5ENSGALG00000016529Gallus gallus
 CDKL5ENSG00000008086Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cdkl2 / Q9QUK0 / Cyclin-dependent kinase-like 2 / Q92772*ENSMUSG0000002940320
Cdkl3 / Q8BLF2 / Cyclin-dependent kinase-like 3 / Q8IVW4*ENSMUSG0000002038917
Cdkl4 / Q3TZA2 / Cyclin-dependent kinase-like 4 / Q5MAI5*ENSMUSG0000003396616
Cdkl1 / Q8CEQ0 / Cyclin-dependent kinase-like 1 / Q00532*ENSMUSG0000002099016
Cdk20 / Q9JHU3 / Cyclin-dependent kinase 20 / Q8IZL9*ENSMUSG0000002148313
Cdk7 / Q03147 / Cyclin-dependent kinase 7 / P50613*ENSMUSG0000006908912


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050773 regulation of dendrite development IEA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0044294 dendritic growth cone IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000813 abnormal hippocampal laminar structure "malformed or missing layers of the laminar structure of the hippocampus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

 MP:0001361 social withdrawal "mice remain physically distant, do not sleep in piles with cagemates" [J:57125]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Pdcd1tm1Hon/Pdcd1tm1Hon
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * BALB/c

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cdkl5tm1.1Cogr/Cdkl5+,Tg(Emx1-cre)#Ito/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J

Allelic Composition: Cdkl5tm1.1Cogr/Y,Tg(Emx1-cre)#Ito/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5+,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
Show

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5+,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5+,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

 MP:0009357 induced seizures "applied stimulation producing uncontrolled electrical activity in the brain, producing a physical convulsion or minor change in physical behavior" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0009456 impaired cued conditioning behavior "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bcl11atm1Ngc/Bcl11a+
Genetic Background: involves: 129S1/Sv

 MP:0010748 abnormal visual evoked potential "anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

 MP:0012444 thin hippocampus molecular cell layer 
Show

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

 MP:0012446 thin hippocampus stratum oriens 
Show

Allelic Composition: Cdkl5tm1.2Cogr/Y
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Cdkl5tm1.2Cogr/Cdkl5tm1.2Cogr,Tg(Thy1-YFP)#Jrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S/Sv * C57BL/6J * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr