| MP:0000063 | reduced bone density | "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315] |
Show
Allelic Composition: Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J
|
| MP:0000160 | kyphosis | "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0000233 | abnormal blood flow velocity | "anomalous rate of flow of the blood through vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0000280 | thin ventricular wall | "decreased depth of the cardiac wall of the heart ventricles" [J:45302] |
Show
Allelic Composition: Aiapy/Aiapy
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000281 | abnormal ventricular septum morphology | "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
Show
Allelic Composition: Aiapy/Aiapy
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0000292 | distended pericardial sacs | "stretched outer parietal layer of the pericardium" [J:25248] |
Show
Allelic Composition: Smn1tm2Cdid/Smn1tm2Cdid
Genetic Background: involves: 129 * C57BL/6
|
| MP:0000477 | abnormal intestine morphology | "malformation of the digestive tube passing from the stomach to the anus" [J:48968] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
|
| MP:0000495 | abnormal colon morphology | "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0000496 | abnormal small intestine morphology | "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0000511 | abnormal intestinal mucosa morphology | "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0000572 | abnormal autopod morphology | "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)46Tro/Tg(SMN2)46Tro
Genetic Background: B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0000588 | thick tail | "a tail with a greater diameter than the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0000592 | short tail | "reduced length of tail compared to control " [J:55583] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0000745 | tremors | "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0000747 | muscle weakness | "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0000748 | progressive muscle weakness | "increasing loss of strength over time" [MGI:CLS, J:67994] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0000753 | paralysis | "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
|
| MP:0000755 | hindlimb paralysis | "loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0000759 | abnormal skeletal muscle morphology | "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2*A111G)591Ahmb/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0000937 | abnormal motor neuron morphology | "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1+,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
|
| MP:0000938 | motor neuron degeneration | "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
|
| MP:0000939 | reduced motor neuron number | "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
Show
Allelic Composition: Bmp7tm1Rob/Bmp7+,Bmp8atm1Blh/Bmp8atm1Blh
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0000940 | abnormal motor neuron innervation | "misprojection or failure to bundle motor axons to an effector tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0000955 | abnormal spinal cord morphology | "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
|
| MP:0000968 | abnormal sensory neuron innervation | "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622] |
Show
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0001007 | abnormal sympathetic system morphology | "malformation of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0001052 | abnormal muscle innervation | "malfomation or misprojection of sensory or motor nerves to targets in muscle" [J:75958] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
|
| MP:0001053 | abnormal neuromuscular synapse | "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1+,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: FVB.Cg-Smn1tm1Hung Tg(SMN2)2Hung/J
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0001071 | abnormal facial nerve morphology | "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL
|
| MP:0001078 | abnormal phrenic nerve | "malformed or misprojection of motor and sensory neuron axons to the diaphragm and other tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL
|
| MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0001212 | skin lesions | "focal patches of inflammation on the skin" [J:30162] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
|
| MP:0001220 | epidermal necrosis | "pathological cell death in the epidermal layer of the skin, usually due to irreversible damage" [J:65146] |
Show
Allelic Composition: Smn1tm4(SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm4(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0001263 | weight loss | "progressive reduction of body weight below normal average for age" [J:45400] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL
|
| MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Pfn2tm1Wit/Pfn2tm1Wit,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0001392 | abnormal locomotor activity | "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1.1Dscd/Smn1tm1.1Dscd
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1.1Dscd
Genetic Background: involves: 129S/SvEv * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
|
| MP:0001405 | impaired coordination | "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0001436 | abnormal suckling behavior | "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001443 | poor grooming | "below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)" [MGI:CLS, J:30404] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001513 | limb grasping | "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Cdid/Smn1tm1.1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
|
| MP:0001523 | impaired righting response | "reduced ability or greater amount of time needed to recover from supine position" [J:25565] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0001524 | impaired limb coordination | "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
|
| MP:0001525 | impaired balance | "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
|
| MP:0001614 | abnormal vasculature | "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
Show
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0001648 | abnormal apoptosis | "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248] |
Show
Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
|
| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
Show
Allelic Composition: Vldlrm1Btlr/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
Allelic Composition: Smn1tm2Cdid/Smn1tm2Cdid
Genetic Background: involves: 129 * C57BL/6
|
| MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
|
| MP:0001943 | abnormal respiration | "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0001954 | respiratory distress | "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0001956 | hypopnea | "breathing that is shallower and/or slower than normal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:64289] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0001957 | apnea | "absence of breathing; sometimes episodic" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17384] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0001958 | emphysema | "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0001973 | increased thermal nociceptive threshold | "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0002066 | abnormal motor capabilities/coordination/movement | "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1.1Jme/Smn1tm1.1Jme
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
|
| MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(Prnp-SMN)92Ahmb/Tg(Prnp-SMN)92Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(Prnp-SMN)92Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Pfn2tm1Wit/Pfn2tm1Wit,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Pfn2tm1Wit/Pfn2+,Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: FVB.Cg-Smn1tm1Hung Tg(SMN2)2Hung/J
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0002085 | abnormal embryonic tissue morphology | "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
|
| MP:0002088 | abnormal embryonic growth/weight/body size | "limited or accelerated growth or development apparent before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Uchl1gad-J/Uchl1gad-J
Genetic Background: involves: BALB/c * C57BL/6
|
| MP:0002100 | abnormal tooth morphology | "atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
|
| MP:0002102 | abnormal ear morphology | "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Qkqk-v/Qkqk-v,Tg(PGK2-Pacrg)#Jus/?
Genetic Background: involves: BTBR * C57BL/6J * DBA/2
|
| MP:0002106 | abnormal muscle physiology | "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0002108 | abnormal muscle morphology | "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sortm1(DTA)Jpmb,Tg(KRT14-cre/ERT)20Efu/?
Genetic Background: involves: 129S/SvEv * CD-1
|
| MP:0002111 | abnormal tail morphology | "abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)46Tro/Tg(SMN2)46Tro
Genetic Background: B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Cdk5r1tm1Lht/Cdk5r1tm1Lht
Genetic Background: involves: 129S4/SvJae
Allelic Composition: Smn1tm1.1Jme/Smn1+
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Cdid/Smn1tm1.1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0002177 | abnormal outer ear morphology | "malformation or malfunction of any components of the auricles or external acoustic meatus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)46Tro/Tg(SMN2)46Tro
Genetic Background: B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0002182 | abnormal astrocyte morphology | "anomalous structure, number or compostion of one of the large neuroglia cells of nervous tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0002184 | abnormal innervation | "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0002188 | small heart | "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0002191 | abnormal artery morphology | "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Aiapy/Aiapy
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0002206 | abnormal CNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0002269 | muscular atrophy | "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Fgf1tm1Bas/Fgf1tm1Bas,Fgf2tm1Bas/Fgf2tm1Bas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0002270 | abnormal alveoli morphology | "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0002314 | abnormal respiratory mechanics | "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0002651 | abnormal sciatic nerve | "malformation, absence or misprojection of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0002663 | failure to form blastocele | "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904] |
Show
Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
|
| MP:0002738 | hyperresponsive to tactile stimuli | "exaggerated reflex action normally induced by touch or pain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1.1Dscd/Smn1tm1.1Dscd
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1.1Dscd
Genetic Background: involves: 129S/SvEv * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
|
| MP:0002795 | dilated cardiomyopathy | "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0002862 | altered righting response | "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0002883 | chromatolysis | "the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons" [dlb:Donna Burkart , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0002913 | abnormal PNS synaptic transmission | "defect in the communication from a neuron to a target across a synapse in the peripheral nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0002914 | abnormal endplate potential activity | "defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3] |
Show
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0003082 | abnormal gastrocnemius morphology | "anomaly in the the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2*A111G)591Ahmb/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0003084 | abnormal skeletal muscle fiber morphology | "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0003201 | extremity edema | "an accumulation of serous fluid in the limbs, paws and tail" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0003233 | prolonged QT interval | "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0003466 | decreased single cell response threshold | "reduction in the value at which a stimulus first elicits a recordable response" [Nmice:Neuromice Consortium Submission] |
Show
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
|
| MP:0003635 | abnormal synaptic transmission | "defect in the communication from a neuron to a target across a synapse " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0003815 | nude | "having no hair at some time during or throughout lifespan, generally referring to primary genetic hairlessness" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0003852 | skeletal muscle necrosis | "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0003858 | enhanced coordination | "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0003896 | prolonged PQ interval | "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0003928 | increased heart rate variability | "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
|
| MP:0003998 | decreased thermal nociceptive threshold | "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0004144 | hypotonia | "decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness" [hdene:Howard Dene , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0004145 | abnormal muscle electrophysiology | "anomaly in the function of the musculature as it relates to electrical phenomena" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0004174 | abnormal spine curvature | "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0004191 | neuronal intranuclear inclusions | "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0004243 | abnormal motor nerve terminal sprouting | "aberrant response of a motor neuron to form new neuritic processes (sprouts) that emerge from the nodes of Ranvier or terminal arborizations in response to nerve injury (such as denervation), application of nerve toxin, or muscle inactivity (usually due to disease)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/Tg(SMN1*A2G)2023Ahmb,Grm7Tg(SMN2)89Ahmb/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0004263 | abnormal limb posture | "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0004297 | abnormal proprioceptive neuron morphology | "any structural anomaly in the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
|
| MP:0004769 | abnormal synaptic vesicle morphology | "any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0004792 | abnormal synaptic vesicle number | "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
|
| MP:0004793 | abnormal synaptic vesicle clustering | "any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0004835 | abnormal miniature endplate potential | "defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0005202 | lethargy | "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0005333 | decreased heart rate | "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0005356 | positive geotaxis | "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0005402 | abnormal action potential | "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0005404 | abnormal axon morphology | "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0005405 | axon degeneration | "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Jme/Smn1tm1Jme,Tg(Eno2-cre)39Jme/0
Genetic Background: involves: 129 * C57BL/6J * SJL
|
| MP:0005407 | hyperalgesia | "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
Show
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0005576 | decreased pulmonary ventilation | "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0005608 | cardiac interstitial fibrosis | "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0006404 | abnormal lumbar dorsal root ganglion morphology | "any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0008108 | abnormal small intestinal villus morphology | "any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0008142 | decreased small intestinal villus size | "reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0008489 | postnatal slow weight gain | "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)46Tro/Tg(SMN2)46Tro
Genetic Background: B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0008571 | abnormal synaptic bouton morphology | "any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters" [MESH:A08.663.542.145.750] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0008762 | embryonic lethality | "death of an animal in the embryonic period (Mus: up to E14)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0009399 | increased skeletal muscle fiber size | "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1.1Dscd/Smn1tm1.1Dscd
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0009400 | decreased skeletal muscle fiber size | "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(Prnp-SMN)92Ahmb/Tg(Prnp-SMN)92Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: B6N.Cg-Smn1tm1Hung Tg(SMN2)2Hung
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: FVB.Cg-Smn1tm1Hung Tg(SMN2)2Hung/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0009402 | decreased skeletal muscle fiber diameter | "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd/J
|
| MP:0009403 | increased variability of skeletal muscle fiber size | "greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0009404 | centrally nucleated skeletal muscle fibers | "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0009406 | decreased skeletal muscle fiber number | "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0009412 | skeletal muscle fiber degeneration | "pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
|
| MP:0009413 | skeletal muscle fiber atrophy | "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
|
| MP:0009434 | paraparesis | "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Rako
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1
|
| MP:0009703 | decreased birth body size | "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
|
| MP:0010053 | decreased grip strength | "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"] |
Show
Allelic Composition: Smn1tm1.1Dscd/Smn1tm1.1Dscd
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Smn1tm1Msd/Smn1tm1.1Dscd
Genetic Background: involves: 129S/SvEv * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
|
| MP:0010090 | increased circulating creatine kinase level | "an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Jme/Smn1tm1.1Jme,Tg(ACTA1-cre)79Jme/0
Genetic Background: involves: 129 * C57BL/6 * SJL
|
| MP:0010124 | decreased bone mineral content | "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm6(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: FVB.129(B6)-Smn1tm5(Smn1/SMN2)Mrph/J
|
| MP:0010392 | prolonged QRS complex duration | "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
|
| MP:0010506 | prolonged RR interval | "increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0010579 | increased heart left ventricle size | "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0010725 | thin interventricular septum | "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Aiapy/Aiapy
Genetic Background: involves: C3H/HeJ * C57BL/6J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1-SMN2*)16Cll/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/0
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
|
| MP:0010900 | abnormal pulmonary interalveolar septum morphology | "any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Gt(ROSA)26Sortm1.1(CAG-PLS3,-GFP)Bwir/Gt(ROSA)26Sor+,Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N * FVB/N
|
| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)69Ahmb/Tg(ACTA1-SMN)69Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/0,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb/J
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7+,Tg(SMN2*delta7)4299Ahmb/0
Genetic Background: FVB.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd Tg(SMN2*delta7)4299Ahmb
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Tg(SMN2*)1951Ahmb/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Tg(SMN2)11Tro Smn1tm1Msd/J
Allelic Composition: Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy/Gt(ROSA)26Sortm1.1(rtTA,EGFP)Nagy,Smn1tm1Msd/Smn1+,Tg(SMN2)#Ahmb/Tg(SMN2)#Ahmb,Tg(SMN2*delta7)4299Ahmb/Tg(SMN2*delta7)4299Ahmb,Tg(tetO-SMN2,-luc)#aAhmb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * FVB
Allelic Composition: Olig2tm1(cre)Tmj/Olig2+,Smn1tm1Jme/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * C57BL/6 * FVB
Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Smn1tm1Cdid/Smn1tm1Cdid,Grm7Tg(SMN2)89Ahmb/Grm7+
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * FVB
|
| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/0,Tg(SMN2)46Tro/0
Genetic Background: B6.Cg-Tg(SMN2)11Tro Tg(SMN2)46Tro Smn1tm1Msd/J
|
| MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2)11Tro/Tg(SMN2)11Tro
Genetic Background: B6.Cg-Smn1tm1Msd Tg(SMN2)11Tro
|
| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
Show
Allelic Composition: Glra1tm1Rah/Glra1tm1Rah
Genetic Background: involves: 129X1/SvJ * C57BL/6J
|
| MP:0011091 | complete prenatal lethality | "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Grhl3ct/Grhl3ct
Genetic Background: STOCK Grhl3ct/J
Allelic Composition: Smn1tm3(SMN2/Smn1)Mrph/Smn1tm3(SMN2/Smn1)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN2*A111G)591Ahmb/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Tg(SMN2*A111G)591Ahmb/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/0,Tg(SMN2*A111G)588Ahmb/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N
|
| MP:0011092 | complete embryonic lethality | "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(SMN1*A2G)2023Ahmb/Tg(SMN1*A2G)2023Ahmb,Grm7Tg(SMN2)89Ahmb/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1.1Jme/Smn1tm1.1Jme
Genetic Background: involves: 129 * C57BL/6 * SJL
Allelic Composition: Smn1tm2Mrph/Smn1tm2Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm2Mrph/Smn1tm4(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm2Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm4(SMN2)Mrph/Smn1tm4(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm4(SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
| MP:0011094 | complete embryonic lethality before implantation | "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith] |
Show
Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)
|
| MP:0011096 | complete embryonic lethality before somite formation | "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith] |
Show
Allelic Composition: Fn1tm1Ref/Fn1tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
|
| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Vldlrm1Btlr/Vldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J
|
| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Smn1tm2Cdid/Smn1tm2Cdid
Genetic Background: involves: 129 * C57BL/6
|
| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
Show
Allelic Composition: Aiapy/Aiapy
Genetic Background: involves: C3H/HeJ * C57BL/6J
|
| MP:0011108 | partial embryonic lethality during organogenesis | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
Show
Allelic Composition: Smn1tm2Cdid/Smn1tm2Cdid
Genetic Background: involves: 129 * C57BL/6
|
| MP:0011400 | complete lethality | "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2] |
Show
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: B6.Cg-Grm7Tg(SMN2)89Ahmb Smn1tm1Msd
Allelic Composition: Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb,Smn1tm1Msd/Smn1tm1Msd
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6J * FVB/N
|
| MP:0013178 | tail necrosis | "morphological changes resulting from pathological death of tail tissue; usually due to irreversible damage" [MGI:anna] |
Show
Allelic Composition: Smn1tm1Hung/Smn1tm1Hung,Tg(SMN2)2Hung/Tg(SMN2)2Hung
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm1Msd/Smn1tm1Msd,Tg(ACTA1-SMN)63Ahmb/Tg(ACTA1-SMN)63Ahmb,Grm7Tg(SMN2)89Ahmb/Grm7Tg(SMN2)89Ahmb
Genetic Background: involves: 129P2/OlaHsd * FVB/N
Allelic Composition: Smn1tm2Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm4(SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm5(Smn1/SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
Allelic Composition: Smn1tm5(Smn1/SMN2)Mrph/Smn1tm6(SMN2)Mrph
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac
|
