| MP:0000217 | abnormal white blood cell count | "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Pnpf/Pnpf
Genetic Background: C57BL/6J-Pnpf
Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
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| MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: H19tm1Lda/H19+
Genetic Background: involves: 129S2/SvPas
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| MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pnpf/Pnpf
Genetic Background: C57BL/6J-Pnpf
Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
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| MP:0002007 | increased sensitivity to gamma-irradiation | "increased incidence of cell death following high levels of gamma-irradiation" [J:51834] |
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Allelic Composition: H19tm1Lda/H19+
Genetic Background: involves: 129S2/SvPas
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| MP:0002442 | abnormal leukocyte physiology | "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pnpf/Pnpf
Genetic Background: C57BL/6J-Pnpf
Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
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| MP:0003132 | increased number of pre-B cells | "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0005079 | defective cytotoxic T cell cytolysis | "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692] |
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Allelic Composition: H19tm1Lda/H19+
Genetic Background: involves: 129S2/SvPas
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| MP:0005090 | increased double-negative T cells count | "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Pnpf/Pnpf
Genetic Background: C57BL/6J-Pnpf
Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0005093 | impaired B cell proliferation | "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6
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| MP:0005584 | abnormal enzyme/coenzyme activity | "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0008058 | abnormal DNA repair | "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281] |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0008075 | decreased CD4-positive T cell number | "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0008079 | decreased CD8-positive T cell number | "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pnpf/Pnpf
Genetic Background: C57BL/6J-Pnpf
Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0008083 | decreased single-positive T cell number | "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0008182 | decreased marginal zone B cell number | "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6
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| MP:0009541 | increased thymocyte apoptosis | "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0010186 | increased T follicular helper cell number | "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402] |
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Allelic Composition: Fcgr2btm1Kgcs/Fcgr2b+
Genetic Background: involves: C57BL/6
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Pnpf/Pnpf
Genetic Background: C57BL/6J-Pnpf
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| MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
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| MP:0011476 | abnormal urine nucleotide level | "any change in the urinary level of glycosamines consisting of a nucleobase, a five-carbon sugar moiety (ribose or deoxyribose), and may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)" [MGI:csmith] |
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pnpf/Pnpf
Genetic Background: involves: C3H/HeHa * C57BL/6J
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| MP:0011477 | abnormal urine nucleoside level | "any change in the urinary level of glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage, including cytidine, uridine, adenosine, guanosine, thymidine and inosine and deoxynucleosides" [MGI:csmith] |
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Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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| MP:0011597 | decreased purine-nucleoside phosphorylase activity | "reduced ability to catalyze the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate" [GO:0004607] |
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Allelic Composition: Baxtm1Sjk/Baxtm1Sjk,Nanos2tm1Ysa/Nanos2tm1Ysa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ
Allelic Composition: Pnpf/Pnpf
Genetic Background: involves: C3H/HeHa * C57BL/6J
Allelic Composition: Pnpg/Pnpg
Genetic Background: involves: C57BL/6 * DBA/2J
Allelic Composition: Pnph/Pnph
Genetic Background: involves: C3H/HeHa * C57BL/6J
Allelic Composition: Pnpi/Pnpi
Genetic Background: involves: C3H/HeHa * C57BL/6J
Allelic Composition: Pnptm1Cmr/Pnptm1Cmr
Genetic Background: involves: 129
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