ENSMUSG00000022108


Mus musculus

Features
Gene ID: ENSMUSG00000022108
  
Biological name :Itm2b
  
Synonyms : Integral membrane protein 2B BRI2, membrane form BRI2 intracellular domain BRI2C, soluble form Bri23 peptide / Itm2b / O89051
  
Possible biological names infered from orthology : integral membrane protein 2B / Q9Y287
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D3
Gene start: 73362226
Gene end: 73385289
  
Corresponding Affymetrix probe sets: 10421557 (MoGene1.0st)   1417999_at (Mouse Genome 430 2.0 Array)   1418000_a_at (Mouse Genome 430 2.0 Array)   1418001_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022704
Ensembl peptide - ENSMUSP00000153948
Ensembl peptide - ENSMUSP00000154011
NCBI entrez gene - 16432     See in Manteia.
MGI - MGI:1309517
RefSeq - NM_008410
RefSeq Peptide - NP_032436
swissprot - O89051
Ensembl - ENSMUSG00000022108
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itm2baENSDARG00000007098Danio rerio
 itm2bbENSDARG00000041505Danio rerio
 ITM2BENSGALG00000016996Gallus gallus
 ITM2BENSG00000136156Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itm2a / Q61500 / Integral membrane protein 2A / O43736*ENSMUSG0000003123941
Itm2c / Q91VK4 / Integral membrane protein 2C CT-BRI3 / Q9NQX7* / integral membrane protein 2C*ENSMUSG0000002622341


Protein motifs (from Interpro)
Interpro ID Name
 IPR007084  BRICHOS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0042985 negative regulation of amyloid precursor protein biosynthetic process IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IGI
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005794 Golgi apparatus IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane IEA
 cellular_componentGO:0031301 integral component of organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome IBA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001458 abnormal object recognition memory "defects in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv

Allelic Composition: Itm2btm2.1Ldad/Itm2b+
Genetic Background: B6.129-Itm2btm2.1Ldad

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Rb1cc1tm1.1Guan/Rb1cc1tm1.1Guan,Tg(Tek-cre)12Flv/0
Genetic Background: B6.Cg-Rb1cc1tm1.1Guan Tg(Tek-cre)12Flv

Allelic Composition: Itm2btm2.1Ldad/Itm2b+
Genetic Background: B6.129-Itm2btm2.1Ldad

 MP:0002801 abnormal long-term recognition memory "defects in long-term memory for objects that is consolidated over hours and days after training." [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Itm2btm1.1Ldad/Itm2btm1.1Ldad
Genetic Background: involves: 129

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Tg(CMV-Serpine1)1Dgi/0
Genetic Background: B6.Cg-Apoetm1Unc Tg(CMV-Serpine1)1Dgi

Allelic Composition: Itm2btm1.1Ldad/Itm2b+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: 129 * C3H * C57BL/6

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Itm2btm1.1Ldad/Itm2btm1.1Ldad
Genetic Background: involves: 129

Allelic Composition: Itm2btm1.1Ldad/Itm2b+
Genetic Background: B6.129-Itm2btm1.1Ldad

Allelic Composition: Itm2btm2.1Ldad/Itm2b+
Genetic Background: B6.129-Itm2btm2.1Ldad

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,E4f1tm1Pisc/E4f1tm1.1Llca,Polr2atm1(cre/ERT2)Bbd/Polr2a+
Genetic Background: involves: 129/Sv * 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Itm2btm1.1Ldad/Itm2btm1.1Ldad
Genetic Background: involves: 129

Allelic Composition: Itm2btm1.1Ldad/Itm2b+
Genetic Background: B6.129-Itm2btm1.1Ldad

Allelic Composition: Itm2btm2.1Ldad/Itm2b+
Genetic Background: B6.129-Itm2btm2.1Ldad

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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