ENSMUSG00000026223


Mus musculus

Features
Gene ID: ENSMUSG00000026223
  
Biological name :Itm2c
  
Synonyms : Integral membrane protein 2C CT-BRI3 / Itm2c / Q91VK4
  
Possible biological names infered from orthology : integral membrane protein 2C / Q9NQX7
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C5
Gene start: 85894281
Gene end: 85908675
  
Corresponding Affymetrix probe sets: 10347980 (MoGene1.0st)   1415961_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140692
Ensembl peptide - ENSMUSP00000027425
NCBI entrez gene - 64294     See in Manteia.
MGI - MGI:1927594
RefSeq - NM_022417
RefSeq - XM_017321919
RefSeq Peptide - NP_071862
swissprot - A0A087WRM2
swissprot - Q91VK4
Ensembl - ENSMUSG00000026223
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 itm2caENSDARG00000043448Danio rerio
 itm2cbENSDARG00000039650Danio rerio
 ITM2CENSGALG00000036111Gallus gallus
 ITM2CENSG00000135916Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Itm2b / O89051 / Integral membrane protein 2B BRI2, membrane form BRI2 intracellular domain BRI2C, soluble form Bri23 peptide / Q9Y287* / integral membrane protein 2B*ENSMUSG0000002210841
Itm2a / Q61500 / Integral membrane protein 2A / O43736*ENSMUSG0000003123935


Protein motifs (from Interpro)
Interpro ID Name
 IPR007084  BRICHOS domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0030182 neuron differentiation IEA
 biological_processGO:0042985 negative regulation of amyloid precursor protein biosynthetic process IBA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005764 lysosome ISO
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0070062 extracellular exosome IBA
 molecular_functionGO:0001540 amyloid-beta binding IEA
 molecular_functionGO:0005524 ATP binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88+
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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