ENSMUSG00000022194


Mus musculus

Features
Gene ID: ENSMUSG00000022194
  
Biological name :Pabpn1
  
Synonyms : Pabpn1 / poly(A) binding protein, nuclear 1 / Q8CCS6
  
Possible biological names infered from orthology : Q86U42
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: C2
Gene start: 54892500
Gene end: 54898169
  
Corresponding Affymetrix probe sets: 10415119 (MoGene1.0st)   10338689 (MoGene1.0st)   10339390 (MoGene1.0st)   10340539 (MoGene1.0st)   10343135 (MoGene1.0st)   10343138 (MoGene1.0st)   10344352 (MoGene1.0st)   10341358 (MoGene1.0st)   10342980 (MoGene1.0st)   10344585 (MoGene1.0st)   1415728_at (Mouse Genome 430 2.0 Array)   1422848_a_at (Mouse Genome 430 2.0 Array)   1422849_a_at (Mouse Genome 430 2.0 Array)   1422850_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133405
Ensembl peptide - ENSMUSP00000133937
Ensembl peptide - ENSMUSP00000133579
Ensembl peptide - ENSMUSP00000022808
Ensembl peptide - ENSMUSP00000112177
Ensembl peptide - ENSMUSP00000115294
Ensembl peptide - ENSMUSP00000122432
Ensembl peptide - ENSMUSP00000123305
NCBI entrez gene - 54196     See in Manteia.
MGI - MGI:1859158
RefSeq - XM_006519272
RefSeq - NM_019402
RefSeq Peptide - NP_062275
swissprot - G3UY42
swissprot - D3YUB9
swissprot - G3UX74
swissprot - Q8CCS6
swissprot - G3UWS5
swissprot - D3Z055
Ensembl - ENSMUSG00000022194
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pabpn1ENSDARG00000045373Danio rerio
 PABPN1ENSG00000100836Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20521 / BCL2L2-PABPN1 readthrough / Q92843* / BCL2L2-PABPN1*ENSMUSG0000009223270
Q5XFR0 / Pabpn1l / poly(A)binding protein nuclear 1-like / A6NDY0* / poly(A) binding protein nuclear 1 like, cytoplasmic*ENSMUSG0000006986732


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034911  Polyadenylate-binding protein 2
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0006378 mRNA polyadenylation TAS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0016973 poly(A)+ mRNA export from nucleus IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:1904247 positive regulation of polynucleotide adenylyltransferase activity IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016607 nuclear speck IEA
 cellular_componentGO:0042405 nuclear inclusion body IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008143 poly(A) binding TAS
 molecular_functionGO:0043621 protein self-association ISO
 molecular_functionGO:0070063 RNA polymerase binding IDA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
mRNA Splicing - Major Pathway
mRNA 3-end processing
Processing of Intronless Pre-mRNAs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1tm2.2Gpvl
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

 MP:0009417 skeletal muscle atrophy "a wasting of skeletal muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0009461 skeletal muscle hypertrophy "increase in the bulk size of the skeletal muscle due to cell enlargement" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

 MP:0010959 abnormal oxidative phosphorylation "any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis" [GO:0006119]
Show

Allelic Composition: Tent5cem1Adki/Tent5cem1Adki
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Pabpn1tm2.2Gpvl/Pabpn1+
Genetic Background: involves: C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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