ENSMUSG00000022682


Mus musculus

Features
Gene ID: ENSMUSG00000022682
  
Biological name :Rrn3
  
Synonyms : B2RS91 / RNA polymerase I-specific transcription initiation factor RRN3 / Rrn3
  
Possible biological names infered from orthology : Q9NYV6 / RRN3 homolog, RNA polymerase I transcription factor
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 13780708
Gene end: 13814839
  
Corresponding Affymetrix probe sets: 10433672 (MoGene1.0st)   1415725_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023363
NCBI entrez gene - 106298     See in Manteia.
MGI - MGI:1925255
RefSeq - NM_001039521
RefSeq Peptide - NP_001034610
swissprot - B2RS91
Ensembl - ENSMUSG00000022682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rrn3ENSDARG00000102997Danio rerio
 RRN3ENSGALG00000041989Gallus gallus
 RRN3ENSG00000085721Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007991  RNA polymerase I specific transcription initiation factor RRN3
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001188 RNA polymerase I transcriptional preinitiation complex assembly IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006352 DNA-templated transcription, initiation IDA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006356 regulation of transcription by RNA polymerase I IEA
 biological_processGO:0006361 transcription initiation from RNA polymerase I promoter IMP
 biological_processGO:0007000 nucleolus organization IMP
 biological_processGO:0007028 cytoplasm organization IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0010976 positive regulation of neuron projection development IEA
 biological_processGO:0042254 ribosome biogenesis IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0048872 homeostasis of number of cells IMP
 biological_processGO:1902254 negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
 biological_processGO:2000142 regulation of DNA-templated transcription, initiation IDA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0001042 RNA polymerase I core binding IBA
 molecular_functionGO:0001164 RNA polymerase I CORE element sequence-specific DNA binding IEA
 molecular_functionGO:0001181 RNA polymerase I general transcription initiation factor activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0070063 RNA polymerase binding IDA


Pathways (from Reactome)
Pathway description
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0003244 loss of dopaminergic neurons "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0005424 jerky movement "continuous, abrupt, faltering motions of the whole body or a portion of the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Park7Gt(XE726)Byg/Park7Gt(XE726)Byg,Pink1tm1.1Wrst/Pink1tm1.1Wrst,Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

 MP:0008830 abnormal nucleolus morphology "any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cdk20tm1a(KOMP)Wtsi/Cdk20tm1a(KOMP)Wtsi
Genetic Background: involves: C57BL/6N

Allelic Composition: Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-icre)9190Gsc/0
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N

Allelic Composition: Park7Gt(XE726)Byg/Park7Gt(XE726)Byg,Pink1tm1.1Wrst/Pink1tm1.1Wrst,Rrn3tm1.1Igt/Rrn3tm1.1Igt,Tg(Slc6a3-cre/ERT2)1Span/0
Genetic Background: involves: 129 * 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

 MP:0012505 increased neural tube apoptosis "increase in the number of cells of the neural tube undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Frem2my-F11/Frem2my-F11
Genetic Background: either: (involves: C3HeB/FeJ * C57BL/6J) or (involves: C3HeB/FeJ * C57BL/6J * M. m. castaneus)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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