ENSMUSG00000023938


Mus musculus

Features
Gene ID: ENSMUSG00000023938
  
Biological name :Aars2
  
Synonyms : Aars2 / Alanine--tRNA ligase, mitochondrial / Q14CH7
  
Possible biological names infered from orthology : alanyl-tRNA synthetase 2, mitochondrial / Q5JTZ9
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B3
Gene start: 45506841
Gene end: 45520842
  
Corresponding Affymetrix probe sets: 10445380 (MoGene1.0st)   1436017_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024733
NCBI entrez gene - 224805     See in Manteia.
MGI - MGI:2681839
RefSeq - XM_017317440
RefSeq - NM_198608
RefSeq - XM_011246401
RefSeq - XM_017317439
RefSeq Peptide - NP_941010
swissprot - Q14CH7
Ensembl - ENSMUSG00000023938
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aars2ENSDARG00000107385Danio rerio
 AARS2ENSGALG00000035337Gallus gallus
 AARS2ENSG00000124608Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aars / Q8BGQ7 / alanyl-tRNA synthetase / P49588*ENSMUSG0000003196045


Protein motifs (from Interpro)
Interpro ID Name
 IPR002318  Alanine-tRNA ligase, class IIc
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR012947  Threonyl/alanyl tRNA synthetase, SAD
 IPR018162  Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily
 IPR018163  Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
 IPR018164  Alanyl-tRNA synthetase, class IIc, N-terminal
 IPR018165  Alanyl-tRNA synthetase, class IIc, core domain
 IPR023033  Alanine-tRNA ligase, eukaryota/bacteria


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006400 tRNA modification IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0006419 alanyl-tRNA aminoacylation IBA
 biological_processGO:0033108 mitochondrial respiratory chain complex assembly IEA
 biological_processGO:0043039 tRNA aminoacylation IEA
 biological_processGO:0070143 mitochondrial alanyl-tRNA aminoacylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0000049 tRNA binding IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004813 alanine-tRNA ligase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016597 amino acid binding IBA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm20(tetO-GFP,-cas9*D10A)Slowe/Col1a1+,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sor+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: 4932438A13Riktm1b(EUCOMM)Hmgu/4932438A13Riktm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-4932438A13Riktm1b(EUCOMM)Hmgu/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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