ENSMUSG00000031960


Mus musculus

Features
Gene ID: ENSMUSG00000031960
  
Biological name :Aars
  
Synonyms : Aars / alanyl-tRNA synthetase / Q8BGQ7
  
Possible biological names infered from orthology : P49588
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 111033144
Gene end: 111057664
  
Corresponding Affymetrix probe sets: 10575550 (MoGene1.0st)   1423685_at (Mouse Genome 430 2.0 Array)   1435544_at (Mouse Genome 430 2.0 Array)   1451083_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034441
Ensembl peptide - ENSMUSP00000122388
NCBI entrez gene - 234734     See in Manteia.
MGI - MGI:2384560
RefSeq - XM_017312748
RefSeq - NM_146217
RefSeq - XM_006530921
RefSeq - XM_006530922
RefSeq - XM_006530924
RefSeq Peptide - NP_666329
swissprot - Q8BGQ7
swissprot - A0A1Y7VE86
Ensembl - ENSMUSG00000031960
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aarsENSDARG00000069142Danio rerio
 AARSENSGALG00000001965Gallus gallus
 AARSENSG00000090861Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aars2 / Q14CH7 / Alanine--tRNA ligase, mitochondrial / Q5JTZ9* / alanyl-tRNA synthetase 2, mitochondrial*ENSMUSG0000002393845


Protein motifs (from Interpro)
Interpro ID Name
 IPR002318  Alanine-tRNA ligase, class IIc
 IPR003156  DHHA1 domain
 IPR009000  Translation protein, beta-barrel domain superfamily
 IPR012947  Threonyl/alanyl tRNA synthetase, SAD
 IPR018162  Alanine-tRNA ligase, class IIc, anti-codon-binding domain superfamily
 IPR018163  Threonyl/alanyl tRNA synthetase, class II-like, putative editing domain superfamily
 IPR018164  Alanyl-tRNA synthetase, class IIc, N-terminal
 IPR018165  Alanyl-tRNA synthetase, class IIc, core domain
 IPR023033  Alanine-tRNA ligase, eukaryota/bacteria


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006400 tRNA modification IMP
 biological_processGO:0006412 translation IEA
 biological_processGO:0006419 alanyl-tRNA aminoacylation IDA
 biological_processGO:0021680 cerebellar Purkinje cell layer development IMP
 biological_processGO:0043039 tRNA aminoacylation IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0050905 neuromuscular process IMP
 biological_processGO:0106074 aminoacyl-tRNA metabolism involved in translational fidelity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000049 tRNA binding IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0002161 aminoacyl-tRNA editing activity IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004812 aminoacyl-tRNA ligase activity IEA
 molecular_functionGO:0004813 alanine-tRNA ligase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Aarssti/Aarstm1.1Slac
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000414 alopecia "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Aarssti/Aarstm1.1Slac
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000418 patchy hair "uneven spots of hair growth on the body" [J:26975]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Aarssti/Aarstm1.1Slac
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002188 small heart "reduced size of the heart relative to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:67044]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

Allelic Composition: Aarssti/Aarstm1.1Slac
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0003809 abnormal hair shaft morphology "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aarssti/Aarstm1Slac
Genetic Background: involves: C57BL/6J

 MP:0010688 hair follicle outer rooth sheath hyperplasia "overdevelopment or increased size, usually due to a increased number of cells, outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Jchaintm3Tl/Jchain+
Genetic Background: involves: 129P2/OlaHsd

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Aarstm1.1Slac/Aars+
Genetic Background: involves: C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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